Purpose We analyzed which contrast-enhanced ultrasound (CEUS) parameters are associated with reduced kidney function in the early postoperative period and are prognostic for kidney function six months after transplantation.

Materials and Methods This prospective observational study included 74 patients in whom quantitative CEUS analysis and Doppler ultrasound were performed early after kidney transplantation (10±6 days). For each region of interest (ROI) the time-to-peak intensity (TTP) and the respective delta between ROIs within interlobar artery, cortex, and medulla were compared. Results were correlated with kidney function at the time of imaging and six months later.

Results Patients with an eGFR<30 ml/min at the time of investigation had significantly slower cortical enhancement with a longer cortical TTP (cTTP: 16.1±0.9 vs. 11.7±0.7 sec, p<0.001), as well as a significant delay between the arterial and cortical phases (c–a), as shown in longer ∆TTP (c–a): 8.2±0.9 vs. 4.2 ± 0.5 sec, p<0.001. There was a significant negative correlation between cTTP and eGFR with a correlation coefficient of −0.37 (p<0.001), as well as between ∆TTP (c–a) and eGFR with a correlation coefficient of −0.40 (p<0.001). Reduced kidney function after 6 months correlated significantly with the findings of the initial CEUS examination (p=0.005, correlation coefficient −0.39).

Conclusion CEUS revealed significant differences in temporal enhancement dynamics in patients with reduced kidney function after transplantation. Quantitative CEUS might therefore be able to depict graft function regarding microvascular damage and be of prognostic value regarding long-term renal outcomes.

Received: 07 March 2024

Accepted after revision: 01 October 2024

Article published online:
06 November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Bibliographical Record
Tina Taut, Felix Kurz, Heinz-Peter Schlemmer, Clara Meinzer, Christoph Mahler, Claudius Speer, Louise Benning, Daniel Göth, Christian Nusshag, Claudia Sommerer, Matthias Schaier, Martin Zeier, Christian Morath, Florian Kälble. Correlation of early contrast-enhanced ultrasound parameters with postoperative graft function and at six months after kidney transplantation. Ultrasound Int Open 2024; 10: a24352176.
DOI: 10.1055/a-2435-2176