Polygenic risk for psychotic disorders in relation to cardiac autonomic dysfunction in unmedicated patients with schizophrenia

Tiihonen J, Lonnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A, Haukka J (2009) <ArticleTitle Language=“En”>11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet Aug 22(9690):620–627

Article  Google Scholar 

Laursen TM, Nordentoft M, Mortensen PB (2014) Excess early mortality in schizophrenia. Annu Rev Clin Psychol 10:425–448

Article  PubMed  Google Scholar 

Olfson M, Gerhard T, Huang C, Crystal S, Stroup TS (2015) Premature Mortality Among Adults With Schizophrenia in the United States. JAMA Psychiatry Dec 72(12):1172–1181

Article  Google Scholar 

Correll CU, Solmi M, Veronese N et al (2017) Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry Jun 16(2):163–180

Article  Google Scholar 

Chen Y, Zhang F, Yan Y, Wang S, Zhang L, Yan F (2022) Sudden Cardiac Death in Schizophrenia During Hospitalization: An Autopsy-Based Study. Front Psychiatry ;13

Correll CU, Detraux J, De Lepeleire J, De Hert M (2015) Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry 2015/06/01(2):119–136

Article  Google Scholar 

Sutterland AL, Blom MT, Ladee K, Lubbers JJM, Cohen D, de Haan L, Tan HL (2019) Increased prevalence of ECG suspicious for Brugada Syndrome in recent onset schizophrenia spectrum disorders. Schizophrenia Res 2019/08/01/ 210:59–65

Article  Google Scholar 

Vohra J (2020) Sudden Cardiac Death in Schizophrenia: A Review. Heart Lung Circulation 2020/10/01(10):1427–1432

Article  Google Scholar 

Sweeting J, Duflou J, Semsarian C (2013) Postmortem analysis of cardiovascular deaths in schizophrenia: A 10-year review. Schizophrenia Res 2013/11/01/ 150(2):398–403

Article  Google Scholar 

Sessa F, Anna V, Messina G et al (2018) Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY) Feb 23(2):166–177

Google Scholar 

Jensen MT, Marott JL, Lange P, Vestbo J, Schnohr P, Nielsen OW, Jensen JS, Jensen GB (2013) Resting heart rate is a predictor of mortality in COPD. Eur Respir J Aug 42(2):341–349

Article  Google Scholar 

Huikuri HV, Stein PK (2013) Heart Rate Variability in Risk Stratification of Cardiac Patients. Prog Cardiovasc Dis 2013/09/01(2):153–159

Article  Google Scholar 

Bär KJ, Letzsch A, Jochum T, Wagner G, Greiner W, Sauer H (2005) Loss of efferent vagal activity in acute schizophrenia. J Psychiatr Res Sep 39(5):519–527

Article  Google Scholar 

Correll CU, Robinson DG, Schooler NR et al (2014) Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study. JAMA Psychiatry Dec 1(12):1350–1363

Article  Google Scholar 

Vancampfort D, Wampers M, Mitchell AJ, Correll CU, De Herdt A, Probst M, De Hert M (2013) A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls. World Psychiatry Oct 12(3):240–250

Article  Google Scholar 

Ringen PA, Engh JA, Birkenaes AB, Dieset I, Andreassen OA (2014) Increased mortality in schizophrenia due to cardiovascular disease - a non-systematic review of epidemiology, possible causes, and interventions. Front Psychiatry 5:137

Article  PubMed  PubMed Central  Google Scholar 

He Q, Bennett AN, Liu J et al (2022) Exploring Lead loci shared between schizophrenia and Cardiometabolic traits. BMC Genomics Aug 25(1):617

Article  Google Scholar 

Strawbridge RJ, Johnston KJA, Bailey MES et al (2021) The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Sci Rep 2021/01/ 11(12):632

Article  CAS  Google Scholar 

Perry BI, Bowker N, Burgess S, Wareham NJ, Upthegrove R, Jones PB, Langenberg C, Khandaker GM (2022) Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses. Schizophr Bull Open Jan 3(1):sgac001

Article  Google Scholar 

Bär KJ (2015) Cardiac Autonomic Dysfunction in Patients with Schizophrenia and Their Healthy Relatives - A Small Review. Front Neurol 6:139

Article  PubMed  PubMed Central  Google Scholar 

Fukuda K, Kanazawa H, Aizawa Y, Ardell JL, Shivkumar K (2015) Cardiac innervation and sudden cardiac death. Circ Res Jun 5(12):2005–2019

Article  Google Scholar 

Ardell JL, Andresen MC, Armour JA et al (2016) Translational neurocardiology: preclinical models and cardioneural integrative aspects. J Physiol Jul 15(14):3877–3909

Article  Google Scholar 

Shivkumar K, Ardell JL (2016) Cardiac autonomic control in health and disease. J Physiol Jul 15(14):3851–3852

Article  Google Scholar 

Hadaya J, Ardell JL (2020) Autonomic Modulation for Cardiovascular Disease. Front Physiol ;11

Bär K-J, Berger S, Metzner M et al (2010) Autonomic dysfunction in unaffected first-degree relatives of patients suffering from schizophrenia. Schizophr Bull 36(5):1050–1058

Article  PubMed  Google Scholar 

Singh JP, Larson MG, O’Donnell CJ, Tsuji H, Evans JC, Levy D (1999) Heritability of Heart Rate Variability. Circulation 1999/05/04 99(17):2251–2254

Article  CAS  Google Scholar 

Su S, Lampert R, Lee F et al (2010) Common genes contribute to depressive symptoms and heart rate variability: the Twins Heart Study. Twin Res Hum Genet Feb 13(1):1–9

Article  Google Scholar 

Golosheykin S, Grant JD, Novak OV, Heath AC, Anokhin AP (2017) Genetic influences on heart rate variability. Int J Psychophysiol May 115:65–73

Article  Google Scholar 

de Geus E, van Lien R, Neijts M, Willemsen G (2015) 17 Genetics of Autonomic Nervous System Activity. The Oxford handbook of molecular psychology :357

Muñoz ML, Jaju D, Voruganti S et al (2018) Heritability and genetic correlations of heart rate variability at rest and during stress in the Oman Family Study. J Hypertens Jul 36(7):1477–1485

Article  Google Scholar 

Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB, Christensen K (2018) Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart Jan 104(1):30–36

Article  Google Scholar 

Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, Nordentoft M, Glenthøj B (2018) Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register. Biol Psychiatry Mar 15(6):492–498

Article  Google Scholar 

Counotte J, Pot-Kolder R, van Roon AM, Hoskam O, van der Gaag M, Veling W (2017) High psychosis liability is associated with altered autonomic balance during exposure to Virtual Reality social stressors. Schizophr Res Jun 184:14–20

Article  Google Scholar 

Clamor A, Lincoln TM, Thayer JF, Koenig J (2016) Resting vagal activity in schizophrenia: meta-analysis of heart rate variability as a potential endophenotype. Br J psychiatry: J mental Sci Jan 208(1):9–16

Article  Google Scholar 

Tegegne BS, Said MA, Ani A et al (2023) Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality. Commun Biol Oct 6(1):1013

Article  CAS  Google Scholar 

Nolte IM, Munoz ML, Tragante V et al (2017) Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun Jun 14:8:15805

Article  Google Scholar 

Newton-Cheh C, Guo CY, Wang TJ, O’Donnell CJ, Levy D, Larson MG (2007) Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet Sep 19(Suppl 1):S7

Article  Google Scholar 

Eppinga RN, Hagemeijer Y, Burgess S et al (2016) Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality. Nat Genet Dec 48(12):1557–1563

Article  CAS  Google Scholar 

van de Vegte YJ, Eppinga RN, van der Ende MY et al (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nat Commun 2023/08/02(1):4646

Article  Google Scholar 

Trubetskoy V, Pardiñas AF, Qi T et al (2022) Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nat Apr 604(7906):502–508

CAS  Google Scholar 

Refisch A, Chung HY, Komatsuzaki S, Schumann A, Mühleisen TW, Nöthen MM, Hübner CA, Bär KJ (2020) A common variation in HCN1 is associated with heart rate variability in schizophrenia. Schizophr Res Nov 18

Refisch A, Komatsuzaki S, Ungelenk M et al (2022) Associations of common genetic risk variants of the muscarinic acetylcholine receptor M2 with cardiac autonomic dysfunction in patients with schizophrenia. World J Biol Psychiatry Mar 9:1–11

Google Scholar 

Refisch A, Komatsuzaki S, Ungelenk M et al (2022) Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia. Genes (Basel) Nov 16 ;13(11)

Diagnostic and statistical manual of mental disorders: DSM-IV: Fourth edition. Washington, DC: American Psychiatric Association, [1994] ©1994; (1994)

Kübler U (2013) Structured Clinical Interview for DSM-IV (SCID). In: Gellman MD, Turner JR (eds) Encyclopedia of Behavioral Medicine. Springer New York, New York, NY, pp 1919–1920

Chapter  Google Scholar 

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261–276

Article  CAS  PubMed  Google Scholar 

Wessel N, Voss A, Malberg H, Ziehmann C, Voss HU, Schirdewan A, Meyerfeldt U, Kurths J (2000) Nonlinear analysis of complex phenomena in cardiological data. Herzschr

留言 (0)

沒有登入
gif