Poland A, Glover E, Kende AS. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem. 1976;251(16):4936–46.
Article CAS PubMed Google Scholar
Opitz CA, Holfelder P, Prentzell MT, Trump S. The complex biology of aryl hydrocarbon receptor activation in cancer and beyond. Biochem Pharmacol. 2023;216:115798.
Article CAS PubMed PubMed Central Google Scholar
Ma J, Chen J, Wang H, Lu D, Liang K. AhR regulates VEGF expression by promoting STAT1 transcriptional activity, thereby affecting endothelial angiogenesis in acute limb ischemia. Chem Biol Interact. 2023;369:110253.
Article CAS PubMed Google Scholar
Fang HH, Hsu J, Su JJ. Etoricoxib enhances aryl hydrocarbon receptor activity. Toxicology. 2023;499:153658.
Article CAS PubMed Google Scholar
Nakai R, Fukuda S, Kawase M, Yamashita Y, Ashida H. Curcumin and its derivatives inhibit 2,3,7,8,-tetrachloro-dibenzo-p-dioxin-induced expression of drug metabolizing enzymes through aryl hydrocarbon receptor-mediated pathway. Biosci Biotechnol Biochem. 2018;82(4):616–28.
Article CAS PubMed Google Scholar
Phillips JL, Lohr CV, Nguyen BD, Buermeyer AB, Kolluri SK. Loss of the aryl hydrocarbon receptor increases tumorigenesis in p53-deficient mice. Toxicol Appl Pharmacol. 2022;454:116191.
Article CAS PubMed Google Scholar
Lkhagva-Yondon E, Seo MS, Oh Y, Jung J, Jeon E, Na K, Yoo HS, Kim WC, Esser C, Song S, U,Jeon MS. The aryl hydrocarbon receptor controls mesenchymal stromal cell-mediated immunomodulation via ubiquitination of eukaryotic elongation factor-2 kinase. Cell Death Dis. 2023;14(12):812.
Article CAS PubMed PubMed Central Google Scholar
Wang M, Guo J, Hart A, L,Li JV. Indole-3-Aldehyde reduces inflammatory responses and restores intestinal epithelial barrier function partially via Aryl Hydrocarbon Receptor (AhR) in experimental colitis models. J Inflamm Res. 2023;16:5845–64.
Article CAS PubMed PubMed Central Google Scholar
Rothhammer V, Quintana FJ. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat Rev Immunol. 2019;19(3):184–97.
Article CAS PubMed Google Scholar
Dean JW, Helm EY, Fu Z, Xiong L, Sun N, Oliff KN, Muehlbauer M, Avram D, Zhou L. The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8(+) T cell differentiation and function. Cell Rep. 2023;42(1):111963.
Article CAS PubMed PubMed Central Google Scholar
Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo J. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer. 2022. https://doi.org/10.1136/jitc-2022-004935.
Article PubMed PubMed Central Google Scholar
Xue P, Fu J, Zhou Y. The Aryl Hydrocarbon receptor and tumor immunity. Front Immunol. 2018;9:286.
Article PubMed PubMed Central Google Scholar
Shin JH, Zhang L, Murillo-Sauca O, Kim J, Kohrt HE, Bui JD, Sunwoo JB. Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2013;110(30):12391–6.
Article CAS PubMed PubMed Central Google Scholar
Masuda K, Kimura A, Hanieh H, Nguyen NT, Nakahama T, Chinen I, Otoyo Y, Murotani T, Yamatodani A, Kishimoto T. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011;23(10):637–45.
Article CAS PubMed Google Scholar
Climaco-Arvizu S, Dominguez-Acosta O, Cabanas-Cortes MA, Rodriguez-Sosa M, Gonzalez FJ, Vega L, Elizondo G. Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization. Life Sci. 2016;155:76–84.
Article CAS PubMed PubMed Central Google Scholar
Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011;478(7368):197–203.
Article CAS PubMed Google Scholar
Sherr DH, Monti S. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Semin Immunopathol. 2013;35(6):705–16.
Article CAS PubMed PubMed Central Google Scholar
Ninkov A, Frank JR, Maggio LA, Bibliometrics. Methods for studying academic publishing. Perspect Med Educ. 2022;11(3):173–6.
Murray IA, Krishnegowda G, DiNatale BC, Flaveny C, Chiaro C, Lin JM, Sharma AK, Amin S, Perdew GH. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010;23(5):955–66.
Article CAS PubMed PubMed Central Google Scholar
Haarmann-Stemmann T, Bothe H, Kohli A, Sydlik U, Abel J, Fritsche E. Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. Drug Metab Dispos. 2007;35(12):2262–9.
Article CAS PubMed Google Scholar
Brandstatter O, Schanz O, Vorac J, Konig J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H. Forster I. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016;6:26091.
Article PubMed PubMed Central Google Scholar
Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martinez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F. The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. J Clin Invest. 2008;118(2):640–50.
CAS PubMed PubMed Central Google Scholar
Liu R, Wang J, Liu Y, Gao Y, Yang R. Regulation of gut microbiota on immune cell ferroptosis: a novel insight for immunotherapy against tumor. Cancer Lett. 2024;598:217115.
Article CAS PubMed Google Scholar
Lim TX, Ahamed M, Reutens DC. The aryl hydrocarbon receptor: a diagnostic and therapeutic target in glioma. Drug Discov Today. 2022;27(2):422–35.
Article CAS PubMed Google Scholar
Sadik A, Somarribas Patterson LF, Ozturk S, Mohapatra SR, Panitz V, Secker PF, Pfander P, Loth S, Salem H, Prentzell MT, Berdel B, Iskar M, Faessler E, Reuter F, Kirst I, Kalter V, Foerster KI, Jager E, Guevara CR, Sobeh M, Hielscher T, Poschet G, Reinhardt A, Hassel JC, Zapatka M, Hahn U, von Deimling A, Hopf C, Schlichting R, Escher BI, Burhenne J, Haefeli WE, Ishaque N, Bohme A, Schauble S, Thedieck K, Trump S, Seiffert M, Opitz CA. IL4I1 is a metabolic Immune checkpoint that activates the AHR and promotes Tumor Progression. Cell. 2020;182(5):1252–70. e34.
Article CAS PubMed Google Scholar
Liu P, Zhou Y, Dong X, Zheng B, Liang B, Liang R, Liu Z, Li L, Gong P. ZNF165 is involved in the regulation of immune microenvironment and promoting the proliferation and migration of hepatocellular carcinoma by AhR/CYP1A1. J Immunol Res. 2022;2022:4446805.
Article PubMed PubMed Central Google Scholar
Perez-Castro L, Garcia R, Venkateswaran N, Barnes S, Conacci-Sorrell M. Tryptophan and its metabolites in normal physiology and cancer etiology. FEBS J. 2023;290(1):7–27.
Article CAS PubMed Google Scholar
Gargaro M, Manni G, Scalisi G, Puccetti P, Fallarino F. Tryptophan metabolites at the crossroad of immune-cell interaction via the aryl hydrocarbon receptor: implications for tumor immunotherapy. Int J Mol Sci. 2021;22(9):4644.
留言 (0)