Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1

Grunewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Alava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. Nat Rev Dis Primers. 2018;4(1):5.

Article  PubMed  Google Scholar 

Abboud A, Masrouha K, Saliba M, Haidar R, Saab R, Khoury N, Tawil A, Saghieh S. Extraskeletal Ewing sarcoma: diagnosis, management and prognosis. Oncol Lett. 2021;21(5):354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Downing JR, Head DR, Parham DM, Douglass EC, Hulshof MG, Link MP, Motroni TA, Grier HE, Curcio-Brint AM, Shapiro DN. Detection of the (11;22)(q24;q12) translocation of Ewing’s sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction. Am J Pathol. 1993;143(5):1294–300.

CAS  PubMed  PubMed Central  Google Scholar 

Riggi N, Stamenkovic I. The biology of Ewing sarcoma. Cancer Lett. 2007;254(1):1–10.

Article  CAS  PubMed  Google Scholar 

Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y. EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing’s sarcoma and primitive neuroectodermal tumor cells. J Clin Invest. 1997;99(2):239–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cotterill SJ, Ahrens S, Paulussen M, Jurgens HF, Voute PA, Gadner H, Craft AW. Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol. 2000;18(17):3108–14.

Article  CAS  PubMed  Google Scholar 

Sannino G, Marchetto A, Kirchner T, Grunewald TGP. Epithelial-to-mesenchymal and mesenchymal-to-epithelial transition in mesenchymal tumors: a paradox in sarcomas? Cancer Res. 2017;77(17):4556–61.

Article  CAS  PubMed  Google Scholar 

Baldini EH, Demetri GD, Fletcher CD, Foran J, Marcus KC, Singer S. Adults with Ewing’s sarcoma/primitive neuroectodermal tumor: adverse effect of older age and primary extraosseous disease on outcome. Ann Surg. 1999;230(1):79–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takenaka S, Naka N, Obata H, Joyama S, Hamada K, Imura Y, Kakunaga S, Aoki Y, Ueda T, Araki N, et al. Treatment outcomes of Japanese patients with Ewing sarcoma: differences between skeletal and extraskeletal Ewing sarcoma. Jpn J Clin Oncol. 2016;46(6):522–8.

Article  PubMed  Google Scholar 

Van Mater D, Wagner L. Management of recurrent Ewing sarcoma: challenges and approaches. Onco Targets Ther. 2019;12:2279–88.

Article  PubMed  PubMed Central  Google Scholar 

Raciborska A, Bilska K, Drabko K, Chaber R, Pogorzala M, Wyrobek E, Polczynska K, Rogowska E, Rodriguez-Galindo C, Wozniak W. Vincristine, irinotecan, and temozolomide in patients with relapsed and refractory Ewing sarcoma. Pediatr Blood Cancer. 2013;60(10):1621–5.

Article  CAS  PubMed  Google Scholar 

Attia S, Bolejack V, Ganjoo KN, George S, Agulnik M, Rushing D, Loggers ET, Livingston MB, Wright J, Chawla SP, et al. A phase II trial of regorafenib in patients with advanced Ewing sarcoma and related tumors of soft tissue and bone: SARC024 trial results. Cancer Med. 2023;12(2):1532–9.

Article  CAS  PubMed  Google Scholar 

Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG. TK216 targets microtubules in Ewing sarcoma cells. Cell Chem Biol. 2022;29(8):1325-1332.e1324.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ludwig JA, Federman NC, Anderson PM, Macy ME, Riedel RF, Davis LE, Daw NC, Wulff J, Kim A, Ratan R, et al. TK216 for relapsed/refractory Ewing sarcoma: interim phase 1/2 results. J Clin Oncol. 2021;39(15_suppl):11500.

Article  Google Scholar 

Crompton BD, Stewart C, Taylor-Weiner A, Alexe G, Kurek KC, Calicchio ML, Kiezun A, Carter SL, Shukla SA, Mehta SS, et al. The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014;4(11):1326–41.

Article  CAS  PubMed  Google Scholar 

Tirode F, Surdez D, Ma X, Parker M, Le Deley MC, Bahrami A, Zhang Z, Lapouble E, Grossetete-Lalami S, Rusch M, et al. Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. Cancer Discov. 2014;4(11):1342–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Surdez D, Zaidi S, Grossetete S, Laud-Duval K, Ferre AS, Mous L, Vourc’h T, Tirode F, Pierron G, Raynal V, et al. STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma. Cancer Cell. 2021;39(6):810-826.e819.

Article  CAS  PubMed  Google Scholar 

Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, et al. STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Cancer Cell. 2021;39(6):827-844.e810.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tirode F, Laud-Duval K, Prieur A, Delorme B, Charbord P, Delattre O. Mesenchymal stem cell features of Ewing tumors. Cancer Cell. 2007;11(5):421–9.

Article  CAS  PubMed  Google Scholar 

Collini P, Sampietro G, Bertulli R, Casali PG, Luksch R, Mezzelani A, Sozzi G, Pilotti S. Cytokeratin immunoreactivity in 41 cases of ES/PNET confirmed by molecular diagnostic studies. Am J Surg Pathol. 2001;25(2):273–4.

Article  CAS  PubMed  Google Scholar 

Schuetz AN, Rubin BP, Goldblum JR, Shehata B, Weiss SW, Liu W, Wick MR, Folpe AL. Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. Mod Pathol. 2005;18(11):1403–10.

Article  CAS  PubMed  Google Scholar 

Franzetti GA, Laud-Duval K, van der Ent W, Brisac A, Irondelle M, Aubert S, Dirksen U, Bouvier C, de Pinieux G, Snaar-Jagalska E, et al. Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells. Oncogene. 2017;36(25):3505–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC. Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell. 2014;25(18):2695–709.

Article  PubMed  PubMed Central  Google Scholar 

Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC. The EWS/FLI oncogene drives changes in cellular morphology, adhesion, and migration in Ewing sarcoma. Genes Cancer. 2012;3(2):102–16.

Article  PubMed  PubMed Central  Google Scholar 

Choo S, Wang P, Newbury R, Roberts W, Yang J. Reactivation of TWIST1 contributes to Ewing sarcoma metastasis. Pediatr Blood Cancer. 2018. https://doi.org/10.1002/pbc.26721.

Article  PubMed  Google Scholar 

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