Reactions of Na2PdCl4 with two equivalents of 5-(p-tolyl)-1,3,4-oxadiazole-2-thiol (MoxSH), afford complex of the type [Pd(MoxS)2] (1). Further reaction  with equivalent mole of diphosphine ligand ( where n = 1 dppm, 2 dppe,  3 dppp,  4 dppb,   (CH2)n = dppf )  or two equivalents of triphenyl phosphine or triphenyl phosphine sulfide affords mixed-ligand complexes of the type [Pd(MoxS)2(Ph2P(CH2)nPPh2)] (2-6), [Pd(MoxS)2(PPh3)2] (7)  and [Pd(MoxS)2(SPPh3)2](8). The prepared complexes were characterized using different physical and spectroscopic methods. The results indicated that the MoxS ligand behave as coordinate in a anion monodentate fashion sulfur atom to give a square planer around the metal ion. Preliminary anti-bacterial activity has been assessed against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis bacteria. The prepared complexes show good activity in compared with standard drug. [Pd(MoxS)2(dppf)] (6) displays good activity (18, 22 and 20 mm) against certain tested microbes Escherichia coli, Staphylococcus aureus and Bacillus subtilis, respectively.

KEY WORDS: Complexes, Palladium, Thione, Anti-bacteria, Phosphine

Bull. Chem. Soc. Ethiop. 2025, 39(1), 79-90.                                                        

DOI: https://dx.doi.org/10.4314/bcse.v39i1.6