Huang, F. L., & Yu, S. J. (2018). Esophageal cancer: Risk factors, genetic association, and treatment. Asian J Surg, 41(3), 210–215.

Article  PubMed  Google Scholar 

Codipilly, D. C., & Wang, K. K. (2022). Squamous cell carcinoma of the esophagus. Gastroenterol Clin North Am, 51(3), 457–484.

Article  PubMed  Google Scholar 

Yang, T., Hui, R., Nouws, J., Sauler, M., Zeng, T., & Wu, Q. (2022). Untargeted metabolomics analysis of esophageal squamous cell cancer progression. J Transl Med, 20(1), 127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

An, L., Li, M., & Jia, Q. (2023). Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma. Mol Cancer, 22(1), 140.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam, A. K. (2020). Introduction: Esophageal squamous cell carcinoma-current status and future advances. Methods Mol Biol, 2129, 1–6.

Article  CAS  PubMed  Google Scholar 

Li, Y., Yang, B., Ma, Y., Peng, X., Wang, Z., & Sheng, B., et al. (2021). Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma. Signal Transduct Target Ther, 6(1), 381.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan, W., Huang, Y., Zheng, H., Li, S., Li, Z., & Yuan, L., et al. (2020). Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms. Biomed Pharmacother, 132, 110915.

Article  CAS  PubMed  Google Scholar 

Liu, X., Mi, X., Wang, Z., Zhang, M., Hou, J., & Jiang, S., et al. (2020). Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway. Cell Death Dis, 11(6), 454.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwok, H. H., Guo, G. L., Lau, J. K., Cheng, Y. K., Wang, J. R., & Jiang, Z. H., et al. (2012). Stereoisomers ginsenosides-20(S)-Rg3 and -20(R)-Rg3 differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma. Biochem Pharm, 83(7), 893–902.

Article  CAS  PubMed  Google Scholar 

Teng, S., Wang, Y., Li, P., Liu, J., Wei, A., & Wang, H., et al. (2017). Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells. Mol Med Rep, 15(4), 2029–2038.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang, Y., Zhang, T., Jing, S., Zuo, P., Li, T., & Wang, Y., et al. (2021). 20(S)-Ginsenoside Rg3 inhibits lung cancer cell proliferation by targeting EGFR-Mediated Ras/Raf/MEK/ERK pathway. Am J Chin Med, 49(3), 753–765.

Article  CAS  PubMed  Google Scholar 

Zhou, Y., Zheng, X., Lu, J., Chen, W., Li, X., & Zhao, L. (2018). Ginsenoside 20(S)-Rg3 inhibits the Warburg effect via modulating DNMT3A/ MiR-532-3p/HK2 pathway in ovarian cancer cells. Cell Physiol Biochem, 45(6), 2548–2559.

Article  CAS  PubMed  Google Scholar 

Pozniak, T., Shcharbin, D., & Bryszewska, M. (2022). Circulating microRNAs in medicine. Int J Mol Sci, 23(7), 3996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saliminejad, K., Khorram Khorshid, H. R., Soleymani Fard, S., & Ghaffari, S. H. (2019). An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J Cell Physiol, 234(5), 5451–5465.

Article  CAS  PubMed  Google Scholar 

Vilimova, M., & Pfeffer, S. (2023). Post-transcriptional regulation of polycistronic microRNAs. Wiley Interdiscip Rev RNA, 14(2), e1749.

Article  CAS  PubMed  Google Scholar 

Pouya, F. D., Rasmi, Y., Gazouli, M., Zografos, E., & Nemati, M. (2022). MicroRNAs as therapeutic targets in breast cancer metastasis. Drug Deliv Transl Res, 12(5), 1029–1046.

Article  CAS  PubMed  Google Scholar 

Jing, Y., Liang, W., Liu, J., Zhang, L., Wei, J., & Yang, J., et al. (2020). Autophagy-mediating microRNAs in cancer chemoresistance. Cell Biol Toxicol, 36(6), 517–536.

Article  CAS  PubMed  Google Scholar 

Ashrafizadeh, M., Ahmadi, Z., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2020). MicroRNAs mediate the anti-tumor and protective effects of ginsenosides. Nutr Cancer, 72(8), 1264–1275.

Article  CAS  PubMed  Google Scholar 

Wang, X., He, R., Geng, L., Yuan, J., & Fan, H. (2022). Ginsenoside Rg3 alleviates cisplatin resistance of gastric cancer cells through inhibiting SOX2 and the PI3K/Akt/mTOR signaling axis by up-regulating miR-429. Front Genet, 13, 823182.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, G. M., Lu, T. C., Sun, M. L., Jia, W. Y., Ji, X., & Luo, Y. G. (2020). Ginsenoside Rd inhibits Glioblastoma cell proliferation by up-regulating the expression of miR-144-5p. Biol Pharm Bull, 43(10), 1534–1541.

Article  CAS  PubMed  Google Scholar 

Gao, Q., & Zheng, J. (2018). Ginsenoside Rh2 inhibits prostate cancer cell growth through suppression of microRNA-4295 that activates CDKN1A. Cell Prolif, 51(3), e12438.

Article  PubMed  PubMed Central  Google Scholar 

Lu, J., Chen, H., He, F., You, Y., Feng, Z., & Chen, W., et al. (2020). Ginsenoside 20(S)-Rg3 upregulates HIF-1α-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells. Clin Exp Pharm Physiol, 47(8), 1455–1463.

Article  CAS  Google Scholar 

Zhang, X. B., Song, Y., Lai, Y. T., Qiu, S. Z., Hu, A. K., & Li, D. X., et al. (2024). MiR-210-3p enhances intermittent hypoxia-induced tumor progression via inhibition of E2F3. Sleep Breath, 28(2), 607–617.

Article  PubMed  Google Scholar 

Kalogirou, C., Ellinger, J., Kristiansen, G., Hatzichristodoulou, G., Kübler, H., & Kneitz, B., et al. (2020). Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis. Transl Androl Urol, 9(3), 1314–1322.

Article  PubMed  PubMed Central  Google Scholar 

Pasculli, B., Barbano, R., Rendina, M., Fontana, A., Copetti, M., & Mazza, T., et al. (2019). Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel. Sci Rep, 9(1), 14913.

Article  PubMed  PubMed Central  Google Scholar 

Fujihara, S., Kobara, H., Nishiyama, N., Hirose, K., Iwama, H., & Masaki, T. (2021). MicroRNA expression profiles in superficial esophageal squamous cell carcinoma before endoscopic submucosal dissection: a pilot study. Int J Mol Sci, 22(9), 4789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, X., Shi, L., Yi, C., Yang, Y., Chang, L., & Song, D. (2017). MiR-210-3p inhibits the tumor growth and metastasis of bladder cancer via targeting fibroblast growth factor receptor-like 1. Am J Cancer Res, 7(8), 1738–1753.

CAS  PubMed  PubMed Central  Google Scholar 

He, H., Liu, J., Li, W., Yao, X., Ren, Q., & Shen, B., et al. (2020). MiR-210-3p inhibits proliferation and migration of C6 cells by targeting Iscu. Neurochem Res, 45(8), 1813–1824.

Article  CAS  PubMed  Google Scholar 

Lu, J., Zhou, Y., Zheng, X., Chen, L., Tuo, X., & Chen, H., et al. (2020). 20(S)-Rg3 upregulates FDFT1 via reducing miR-4425 to inhibit ovarian cancer progression. Arch Biochem Biophys, 693, 108569.

Article  CAS  PubMed  Google Scholar 

Xi, E., Bai, J., Zhang, K., Yu, H., & Guo, Y. (2022). Genomic variants disrupt miRNA-mRNA regulation. Chem Biodivers, 19(10), e202200623.

Article  CAS