Ethics Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed Consent

Informed consent was obtained from all individual participants included in the study prior to procedures and genetic testing.

Competing Interests

Andres Acosta and Mayo Clinic hold equity in Phenomix Sciences Inc. and are inventors of intellectual property licensed to Phenomix Sciences Inc. AA served as a consultant for Rhythm Pharmaceuticals, General Mills, Amgen, Bausch Health, and RareStone and has contracts with Vivus Inc, Satiogen Pharmaceutical, and Rhythm pharmaceutical. No other disclosure to be reported. The Mayo Clinic Biobank is supported by the Mayo Clinic Center for Individualized Medicine. Andrew C. Storm has research grants from Apollo Endosurgery, Boston Scientific, Endogenex, Enterasense, and OnePass and is a consultant for Apollo Endosurgery, Boston Scientific, Endogenex, Endo-TAGSS, MGI Medical, Olympus, Intuitive, Medtronic, and Microtech. Barham Abu Dayehh is a consultant for DyaMx, Boston Scientific, USGI Medical, and Endo-TAGSS; gets research support from Boston Scientific, USGI Medical, Apollo Endosurgery, Spatz Medical, GI Dynamics, Cairn Diagnostics, Aspire Bariatrics, and Medtronic; and is a speaker for Johnson and Johnson, Endogastric Solutions, and Olympus.