Association As. 2019 Alzheimer's disease facts and figures. Alzheimer's & dementia. 2019;15(3):321-87.

Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, et al. Alzheimer's disease. The Lancet. 2021;397(10284):1577-90.

Association As. 2017 Alzheimer's disease facts and figures. Alzheimer's & Dementia. 2017;13(4):325-73.

Takizawa C, Thompson PL, van Walsem A, Faure C, Maier WC. Epidemiological and economic burden of Alzheimer's disease: a systematic literature review of data across Europe and the United States of America. Journal of Alzheimer's disease. 2015;43(4):1271-84.

Patterson C. World alzheimer report 2018. 2018.

Mayeda ER, Glymour MM, Quesenberry CP, Johnson JK, Pérez-Stable EJ, Whitmer RA. Survival after dementia diagnosis in five racial/ethnic groups. Alzheimer's & Dementia. 2017;13(7):761-9.

Rhodius-Meester HFM, Tijms BM, Lemstra AW, Prins ND, Pijnenburg YA, Bouwman F, et al. Survival in memory clinic cohort is short, even in young-onset dementia. Journal of Neurology, Neurosurgery & Psychiatry. 2019;90(6):726-8.

Lopez JAS, González HM, Léger GC. Alzheimer's disease. Handbook of clinical neurology. 2019;167:231-55.

Fergusson JE. The heavy elements: chemistry, environmental impact and health effects. (No Title). 1990.

Kim J-J, Kim Y-S, Kumar V. Heavy metal toxicity: An update of chelating therapeutic strategies. Journal of Trace elements in Medicine and Biology. 2019;54:226-31.

Gautam PK, Gautam RK, Banerjee S, Chattopadhyaya M, Pandey J. Heavy metals in the environment: fate, transport, toxicity and remediation technologies. Nova Sci Publishers. 2016;60:101-30.

Bradl H. Heavy metals in the environment: origin, interaction and remediation: Elsevier; 2005.

Rehman K, Fatima F, Waheed I, Akash MSH. Prevalence of exposure of heavy metals and their impact on health consequences. Journal of cellular biochemistry. 2018;119(1):157-84.

Hussien HM, Abd-Elmegied A, Ghareeb DA, Hafez HS, Ahmed HE, Abd El-moneam N. Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats. Food and chemical toxicology. 2018;111:432-44.

Peres TV, Eyng H, Lopes SC, Colle D, Gonçalves FM, Venske DK, et al. Developmental exposure to manganese induces lasting motor and cognitive impairment in rats. Neurotoxicology. 2015;50:28-37.

Gerhardsson L, Lundh T, Minthon L, Londos E. Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer’s disease. Dementia and geriatric cognitive disorders. 2008;25(6):508-15.

Li B, Xia M, Zorec R, Parpura V, Verkhratsky A. Astrocytes in heavy metal neurotoxicity and neurodegeneration. Brain research. 2021;1752:147234.

Shapiro SC. Encyclopedia of artificial intelligence second edition. New Jersey: A Wiley Interscience Publication. 1992.

Holmes J, Sacchi L, Bellazzi R. Artificial intelligence in medicine. Ann R Coll Surg Engl. 2004;86:334-8.

Koprowski R, Foster KR. Machine learning and medicine: book review and commentary. Springer; 2018.

Strumylaite L, Kregzdyte R, Kucikiene O, Baranauskiene D, Simakauskiene V, Naginiene R, et al. Alzheimer’s disease association with metals and metalloids concentration in blood and urine. International Journal of Environmental Research and Public Health. 2022;19(12):7309.

Wallin C, Friedemann M, Sholts SB, Noormägi A, Svantesson T, Jarvet J, et al. Mercury and Alzheimer’s disease: Hg (II) ions display specific binding to the amyloid-β peptide and hinder its fibrillization. Biomolecules. 2020;10(1):44.

Zhang Q, Lin Y, Yang L, Wang W, Jiang Y, Li H. Exposure to a Mixture of Metals and Cognitive Function in Older Adults: Nhanes 2011-2014.

Babić Leko M, Mihelčić M, Jurasović J, Nikolac Perković M, Španić E, Sekovanić A, et al. Heavy metals and essential metals are associated with cerebrospinal fluid biomarkers of Alzheimer’s disease. International journal of molecular sciences. 2022;24(1):467.

Haley BE. The relationship of the toxic effects of mercury to exacerbation of the medical condition classified as Alzheimer’s disease. Medical Veritas. 2007;4(2):1510-24.

Szabo ST, Harry GJ, Hayden KM, Szabo DT, Birnbaum L. Comparison of metal levels between postmortem brain and ventricular fluid in Alzheimer’s disease and nondemented elderly controls. Toxicological Sciences. 2016;150(2):292-300.

Siblerud R, Mutter J, Moore E, Naumann J, Walach H. A hypothesis and evidence that mercury may be an etiological factor in Alzheimer’s disease. International journal of environmental research and public health. 2019;16(24):5152.

Panch T, Szolovits P, Atun R. Artificial intelligence, machine learning and health systems. Journal of global health. 2018;8(2).

Henglin M, Stein G, Hushcha PV, Snoek J, Wiltschko AB, Cheng S. Machine learning approaches in cardiovascular imaging. Circulation: Cardiovascular Imaging. 2017;10(10):e005614.

Malik P, Pathania M, Rathaur VK. Overview of artificial intelligence in medicine. Journal of family medicine and primary care. 2019;8(7):2328-31.

Datta S, Barua R, Das J. Application of artificial intelligence in modern healthcare system. Alginates-recent uses of this natural polymer. 2019.

Vellingiri B, Suriyanarayanan A, Selvaraj P, Abraham KS, Pasha MY, Winster H, et al. Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity. Chemosphere. 2022;301:134625.

Chanpiwat P, Himeno S, Sthiannopkao S. Arsenic and other metals’ presence in biomarkers of Cambodians in arsenic contaminated areas. International Journal of Environmental Research and Public Health. 2015;12(11):14285-300.

Yadav N, Maurya BM, Chettri D, Pulwani C, Jajula M, Elangovan A, et al. Artificial intelligence in heavy metals detection: Methodological and ethical challenges. Hygiene and Environmental Health Advances. 2023:100071.

Luo J, Hendryx M. Metal mixtures and kidney function: An application of machine learning to NHANES data. Environmental Research. 2020;191:110126.

Wang K, Xia F, Li Q, Luo X, Wu J. The associations of weekend warrior activity patterns with the visceral adiposity index in US adults: repeated cross-sectional study. JMIR Public Health and Surveillance. 2023;9(1):e41973.

Johnson KW, Torres Soto J, Glicksberg BS, Shameer K, Miotto R, Ali M, et al. Artificial intelligence in cardiology. Journal of the American College of Cardiology. 2018;71(23):2668-79.

Lopez K, Fodeh SJ, Allam A, Brandt CA, Krauthammer M. Reducing annotation burden through multimodal learning. Frontiers in big Data. 2020;3:19.

Sun TQ, Medaglia R. Mapping the challenges of Artificial Intelligence in the public sector: Evidence from public healthcare. Government Information Quarterly. 2019;36(2):368-83.

Dilsizian SE, Siegel EL. Artificial intelligence in medicine and cardiac imaging: harnessing big data and advanced computing to provide personalized medical diagnosis and treatment. Current cardiology reports. 2014;16:1-8.

Wiens J, Shenoy ES. Machine learning for healthcare: on the verge of a major shift in healthcare epidemiology. Clinical infectious diseases. 2018;66(1):149-53.

Kleinberg J, Ludwig J, Mullainathan S, Sunstein CR. Discrimination in the Age of Algorithms. Journal of Legal Analysis. 2018;10:113-74.

Houlton S. How artificial intelligence is transforming healthcare. Prescriber. 2018;29(10):13-7.

Wang F, Preininger A. AI in health: state of the art, challenges, and future directions. Yearbook of medical informatics. 2019;28(01):016-26.

Kahn Jr CE. From images to actions: opportunities for artificial intelligence in radiology. Radiological Society of North America; 2017. p. 719-20.

Atri A. The Alzheimer’s disease clinical spectrum: diagnosis and management. Medical Clinics. 2019;103(2):263-93.

Helaluddin A, Khalid RS, Alaama M, Abbas SA. Main analytical techniques used for elemental analysis in various matrices. Tropical Journal of Pharmaceutical Research. 2016;15(2):427-34.

Voica C, Kovacs MH, Dehelean A, Ristoiu D, Iordache A. ICP-MS determinations of heavy metals in surface waters from Transylvania. Romanian Journal of Physics. 2012;57(6-7):1184-93.

Srivastava J, Routray S, Ahmad S, Waris MM. Internet of Medical Things (IoMT)-based smart healthcare system: Trends and progress. Computational Intelligence and Neuroscience. 2022;2022.

Park J-H, Lee D-W, Park KS, Joung H. Serum trace metal levels in Alzheimer’s disease and normal control groups. American Journal of Alzheimer's Disease & Other Dementias®. 2014;29(1):76-83.

Pamphlett R, Kum Jew S. Different populations of human locus ceruleus neurons contain heavy metals or hyperphosphorylated Tau: implications for amyloid-β and tau pathology in Alzheimer's disease. Journal of Alzheimer's Disease. 2015;45(2):437-47.

Lafta H, AlMayaly I. Potential effect of several heavy metals with Alzheimer’s disease infection. Annals of the Romanian Society for Cell Biology. 2021;25(6):3476-84.

Kechko OI, Adzhubei AA, Tolstova AP, Indeykina MI, Popov IA, Zhokhov SS, et al. Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation. International journal of molecular sciences. 2023;24(14):11241.

Brewer GJ, Kanzer SH, Zimmerman EA, Molho ES, Celmins DF, Heckman SM, et al. Subclinical zinc deficiency in Alzheimer’s disease and Parkinson’s disease. American Journal of Alzheimer's Disease & Other Dementias®. 2010;25(7):572-5.

Shippy DC, Ulland TK. Exploring the zinc-related transcriptional landscape in Alzheimer’s disease. IBRO Neuroscience Reports. 2022;13:31-7.

Sanchez G. Las instituciones deficiencia y tecnología en los procesos de aprendizaje de la producción agroalimentaria en Argentina. El Sist argentino innovación Inst Empres y redes El desafío la creación y apropiación Conoc. 2013;48:659-64.

Zafar R, Zubair M, Ali S, Shahid K, Waseem W, Naureen H, et al. Zinc metal carboxylates as potential anti-Alzheimer’s candidate: in vitro anticholinesterase, antioxidant and molecular docking studies. Journal of Biomolecular Structure and Dynamics. 2021;39(3):1044-54.

Xu J, Church SJ, Patassini S, Begley P, Waldvogel HJ, Curtis MA, et al. Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia. Metallomics. 2017;9(8):1106-19.

Agarwal R, Kushwaha SS, Tripathi C, Singh N, Chhillar N. Serum copper in Alzheimer’s disease and vascular dementia. Indian Journal of Clinical Biochemistry. 2008;23:369-74.

Behbehani GR, Barzegar L, Mohebbian M, Saboury A. A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin. Bioinorganic Chemistry and Applications. 2012;2012.

Squitti R, Ghidoni R, Simonelli I, Ivanova ID, Colabufo NA, Zuin M, et al. Copper dyshomeostasis in Wilson disease and Alzheimer's disease as shown by serum and urine copper indicators. Journal of Trace Elements in Medicine and Biology. 2018;45:181-8.

Hsu H-W, Rodriguez-Ortiz CJ, Lim SL, Zumkehr J, Kilian JG, Vidal J, et al. Copper-induced upregulation of microRNAs directs the suppression of endothelial LRP1 in Alzheimer’s disease model. Toxicological sciences. 2019;170(1):144-56.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, et al. Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia. Scientific reports. 2016;6(1):27524.

Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J. Copper depletion down-regulates expression of the Alzheimer's disease amyloid-β precursor protein gene. Journal of Biological Chemistry. 2004;279(19):20378-86.

Opare SK, Rauk A. Copper (I) chelators for Alzheimer’s disease. The Journal of Physical Chemistry B. 2017;121(50):11304-10.

Rembach A, Doecke JD, Roberts BR, Watt AD, Faux NG, Volitakis I, et al. Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease. Journal of Alzheimer's Disease. 2013;34(1):171-82.

Brewer GJ, Kanzer SH, Zimmerman EA, Celmins DF, Heckman SM, Dick R. Copper and ceruloplasmin abnormalities in Alzheimer’s disease. American Journal of Alzheimer's Disease & Other Dementias®. 2010;25(6):490-7.

Zhang Y, Yang Y-s, Wang C-m, Chen W-c, Chen X-l, Wu F, et al. Copper metabolism-related Genes in entorhinal cortex for Alzheimer's disease. Scientific Reports. 2023;13(1):17458.

Park JH, Lee DW, Park KS. Elevated serum copper and ceruloplasmin levels in A lzheimer's disease. Asia‐Pacific Psychiatry. 2014;6(1):38-45.

Agarwal P, Ayton S, Agrawal S, Dhana K, Bennett DA, Barnes LL, et al. Brain copper may protect from cognitive decline and Alzheimer’s disease pathology: A community-based study. Molecular psychiatry. 2022;27(10):4307-13.

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, et al. Targeting copper (II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules. Journal of inorganic biochemistry. 2016;161:52-62.

Kola A, Hecel A, Lamponi S, Valensin D. Novel perspective on Alzheimer’s disease treatment: Rosmarinic acid molecular interplay with copper (II) and amyloid β. Life. 2020;10(7):118.

Madsen SJ, DiGiacomo PS, Zeng Y, Goubran M, Chen Y, Rutt BK, et al. Correlative microscopy to localize and characterize iron deposition in Alzheimer’s disease. Journal of Alzheimer's Disease Reports. 2020;4(1):525-36.

Yang A, Du L, Gao W, Liu B, Chen Y, Wang Y, et al. Associations of cortical iron accumulation with cognition and cerebral atrophy in Alzheimer’s disease. Quantitative Imaging in Medicine and Surgery. 2022;12(9):4570.

Kweon OJ, Youn YC, Lim YK, Lee M-K, Kim HR. Clinical utility of serum hepcidin and iron profile measurements in Alzheimer's disease. Journal of the Neurological Sciences. 2019;403:85-91.

Jouini N, Saied Z, Ben Sassi S, Nebli F, Messaoud T, Hentati F, et al. Impacts of iron metabolism dysregulation on Alzheimer’s disease. Journal of Alzheimer's Disease. 2021;80(4):1439-50.

Petit P, Gondard E, Gandon G, Moreaud O, Sauvée M, Bonneterre V. Agricultural activities and risk of Alzheimer’s disease: the TRACTOR project, a nationwide retrospective cohort study. European Journal of Epidemiology. 2024:1-17.

Hilgemberg GR, Silva AJdOKd, Fermino BL, Diedrich C, Benincá SC, Pinheiro DF, et al. Adequacy of food consumption in elderly Alzheimer’s disease in a community of Southern Brazil: a Cross-sectional study. F1000Research. 2018;7:671.

Lin Y-K, Liang C-S, Tsai C-K, Tsai C-L, Lee J-T, Sung Y-F, et al. A metallomic approach to assess associations of plasma metal levels with amnestic mild cognitive impairment and alzheimer’s disease: an exploratory study. Journal of Clinical Medicine. 2022;11(13):3655.

Elfaks S. Association Between Blood Manganese and Cognitive Function in a National Representative Survey: University of Haifa (Israel); 2021.

Karimi G, Ziarati P. Heavy metal contamination of popular nail polishes in Iran. Iranian Journal of Toxicology. 2015;9(29):1290-5.