Johnson, D. B., Nebhan, C. A., Moslehi, J. J. & Balko, J. M. Immune-checkpoint inhibitors: long-term implications of toxicity. Nat. Rev. Clin. Oncol. 19, 254–267 (2022).
Article PubMed PubMed Central Google Scholar
Marin-Acevedo, J. A. et al. Next generation of immune checkpoint therapy in cancer: new developments and challenges. J. Hematol. Oncol. 11, 39 (2018).
Article PubMed PubMed Central Google Scholar
Jin, S. et al. Emerging new therapeutic antibody derivatives for cancer treatment. Signal. Transduct. Target. Ther. 7, 39 (2022).
Article CAS PubMed PubMed Central Google Scholar
Labrijn, A. F., Janmaat, M. L., Reichert, J. M. & Parren, P. W. H. I. Bispecific antibodies: a mechanistic review of the pipeline. Nat. Rev. Drug. Discov. 18, 585–608 (2019).
Article CAS PubMed Google Scholar
van de Donk, N. W. C. J. & Zweegman, S. T-cell-engaging bispecific antibodies in cancer. Lancet 402, 142–158 (2023).
Klein, C., Brinkmann, U., Reichert, J. M. & Kontermann, R. E. The present and future of bispecific antibodies for cancer therapy. Nat. Rev. Drug. Discov. 23, 301–319 (2024).
Article CAS PubMed Google Scholar
Goebeler, M. E., Stuhler, G. & Bargou, R. Bispecific and multispecific antibodies in oncology: opportunities and challenges. Nat. Rev. Clin. Oncol. 21, 539–560 (2024).
Przepiorka, D. et al. FDA approval: blinatumomab. Clin. Cancer Res. 21, 4035–4039 (2015).
Article CAS PubMed Google Scholar
Deshaies, R. J. Multispecific drugs herald a new era of biopharmaceutical innovation. Nature 580, 329–338 (2020).
Article CAS PubMed Google Scholar
Saez-Ibanez, A. R., Upadhaya, S. & Campbell, J. Immuno-oncology clinical trials take a turn beyond PD1/PDL1 inhibitors. Nat. Rev. Drug. Discov. 22, 442–443 (2023).
Article CAS PubMed Google Scholar
Saez-Ibañez, A. R., Sommers, E., Upadhaya, S. & Campbell, J. PD1/PDL1 clinical trials adapt to a growing landscape of patients resistant to PDx. Nat. Rev. Drug. Discov. 22, 944–945 (2023).
Kantarjian, H. et al. Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia. N. Engl. J. Med. 376, 836–847 (2017).
Article CAS PubMed PubMed Central Google Scholar
Stein, A. S. et al. Neurologic adverse events in patients with relapsed/refractory acute lymphoblastic leukemia treated with blinatumomab: management and mitigating factors. Ann. Hematol. 98, 159–167 (2019).
Article CAS PubMed Google Scholar
Frey, N. V. & Porter, D. L. Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia. Am. Soc. Hematol. Educ. Program. 2016, 567–572 (2016).
Li, H., Er Saw, P. & Song, E. Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics. Cell Mol. Immunol. 17, 451–461 (2020).
Article CAS PubMed PubMed Central Google Scholar
Sun, D., Gao, W., Hu, H. & Zhou, S. Why 90% of clinical drug development fails and how to improve it? Acta Pharm. Sin. B. 12, 3049–3062 (2022).
Article CAS PubMed PubMed Central Google Scholar
Irani, V. et al. Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases. Mol. Immunol. 67, 171–182 (2015).
Article CAS PubMed Google Scholar
Saunders, K. O. Conceptual approaches to modulating antibody effector functions and circulation half-life. Front. Immunol. 10, 1296 (2019).
Article CAS PubMed PubMed Central Google Scholar
Zinn, S. et al. Advances in antibody-based therapy in oncology. Nat. Cancer 4, 165–180 (2023).
Edwards, C. J. et al. The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity. Br. J. Cancer 126, 1168–1177 (2022).
Article CAS PubMed Google Scholar
Archer, S. et al. CB307: a dual targeting costimulatory Humabody VH therapeutic for treating PSMA-positive tumors. Clin. Cancer Res. 30, 1595–1606 (2024).
Article CAS PubMed PubMed Central Google Scholar
Power, C. A. & Bates, A. David vs. Goliath: the structure, function, and clinical prospects of antibody fragments. Antibodies 8, 28 (2019).
Article PubMed PubMed Central Google Scholar
Suurs, F. V., Lub-de Hooge, M. N., de Vries, E. G. E. & de Groot, D. J. A. A review of bispecific antibodies and antibody constructs in oncology and clinical challenges. Pharmacol. Ther. 201, 103–119 (2019).
Article CAS PubMed Google Scholar
Al Ojaimi, Y. et al. Therapeutic antibodies – natural and pathological barriers and strategies to overcome them. Pharmacol. Ther. 233, 108022 (2022).
Article CAS PubMed Google Scholar
Bensch, F. et al. Comparative biodistribution analysis across four different 89Zr-monoclonal antibody tracers – the first step towards an imaging warehouse. Theranostics 8, 4295–4304 (2018).
Article CAS PubMed PubMed Central Google Scholar
Lu, G. et al. Predicting therapeutic antibody delivery into human head and neck cancers. Clin. Cancer Res. 26, 2582–2594 (2020).
Article CAS PubMed PubMed Central Google Scholar
Dennis, M. S. et al. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. Cancer Res. 67, 254–261 (2007).
Article CAS PubMed Google Scholar
Mir, O. et al. Pharmacokinetics/pharmacodynamic (PK/PD) relationship of therapeutic monoclonal antibodies used in oncology: what’s new? Eur. J. Cancer 128, 103–106 (2020).
Article CAS PubMed Google Scholar
Ryman, J. T. & Meibohm, B. Pharmacokinetics of monoclonal antibodies. Clin. Pharmacokinet. 6, 493–507 (2017).
Keizer, R. J., Huitema, A. D. R., Schellens, J. H. M. & Beijnen, J. H. Clinical pharmacokinetics of therapeutic monoclonal antibodies. Clin. Pharmacokinet. 49, 493–507 (2010).
Article CAS PubMed Google Scholar
Roopenian, D. C. & Akilesh, S. FcRn: the neonatal Fc receptor comes of age. Nat. Rev. Immunol. 7, 715–725 (2007).
Article CAS PubMed Google Scholar
Sharma, S. K. et al. Fc-mediated anomalous biodistribution of therapeutic antibodies in immunodeficient mouse models. Cancer Res. 78, 1820–1832 (2018).
留言 (0)