Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022).
Article CAS PubMed PubMed Central Google Scholar
Vollger, M. R. et al. Segmental duplications and their variation in a complete human genome. Science 376, eabj6965 (2022).
Article CAS PubMed PubMed Central Google Scholar
Hoyt, S. J. et al. From telomere to telomere: the transcriptional and epigenetic state of human repeat elements. Science 376, eabk3112 (2022).
Article CAS PubMed PubMed Central Google Scholar
Gershman, A. et al. Epigenetic patterns in a complete human genome. Science 376, eabj5089 (2022).
Article CAS PubMed PubMed Central Google Scholar
Altemose, N. et al. Complete genomic and epigenetic maps of human centromeres. Science 376, eabl4178 (2022).
Article CAS PubMed PubMed Central Google Scholar
Aganezov, S. et al. A complete reference genome improves analysis of human genetic variation. Science 376, eabl3533 (2022).
Article CAS PubMed PubMed Central Google Scholar
Liao, W.-W. et al. A draft human pangenome reference. Nature 617, 312–324 (2023).
Article CAS PubMed PubMed Central Google Scholar
Gao, Y. et al. A pangenome reference of 36 Chinese populations. Nature 619, 112–121 (2023).
Wang, T. et al. The Human Pangenome Project: a global resource to map genomic diversity. Nature 604, 437–446 (2022).
Article CAS PubMed PubMed Central Google Scholar
Huang, T., Shu, Y. & Cai, Y.-D. Genetic differences among ethnic groups. BMC Genomics 16, 1093 (2015).
Article PubMed PubMed Central Google Scholar
Gest, H. The discovery of microorganisms by Robert Hooke and Antoni van Leeuwenhoek, Fellows of The Royal Society. Notes Rec. R. Soc. Lond. 58, 187–201 (2004).
The Integrative HMP (iHMP) Research Network Consortium. The Integrative Human Microbiome Project. Nature 569, 641–648 (2019).
Lloyd-Price, J. et al. Strains, functions and dynamics in the expanded Human Microbiome Project. Nature 550, 61–66 (2017).
Article CAS PubMed PubMed Central Google Scholar
Integrative HMP (iHMP) Research Network Consortium. The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease. Cell Host Microbe 16, 276–289 (2014).
The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214 (2012).
Article PubMed Central Google Scholar
MetaHIT Consortium. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65 (2010).
Article PubMed Central Google Scholar
Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541–546 (2013).
MetaHIT Consortium. et al. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 32, 834–841 (2014).
MetaHIT Consortium (additional members). et al. Enterotypes of the human gut microbiome. Nature 473, 174–180 (2011).
MetaHIT consortium. et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 528, 262–266 (2015).
Article PubMed Central Google Scholar
McDonald, D. et al. American gut: an open platform for citizen science microbiome research. mSystems 3, e00031–18 (2018).
Article CAS PubMed PubMed Central Google Scholar
Lopera-Maya, E. A. et al. Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. Nat. Genet. 54, 143–151 (2022).
Article CAS PubMed Google Scholar
López-Otín, C. & Kroemer, G. Hallmarks of Health. Cell 184, 33–63 (2021).
Schmauck-Medina, T. et al. New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary. Aging 14, 6829–6839 (2022).
Article PubMed PubMed Central Google Scholar
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding universe. Cell 186, 243–278 (2023).
Nicholson, J. K. et al. Host-gut microbiota metabolic interactions. Science 336, 1262–1267 (2012).
Article CAS PubMed Google Scholar
Cho, I. & Blaser, M. J. The human microbiome: at the interface of health and disease. Nat. Rev. Genet. 13, 260–270 (2012).
Article CAS PubMed PubMed Central Google Scholar
Gilbert, J. A. et al. Current understanding of the human microbiome. Nat. Med. 24, 392–400 (2018).
Article CAS PubMed PubMed Central Google Scholar
Rackaityte, E. & Lynch, S. V. The human microbiome in the 21st century. Nat. Commun. 11, 5256 (2020).
Article CAS PubMed PubMed Central Google Scholar
Cani, P. D. Human gut microbiome: hopes, threats and promises. Gut 67, 1716–1725 (2018).
Article CAS PubMed Google Scholar
de Vos, W. M., Tilg, H., Van Hul, M. & Cani, P. D. Gut microbiome and health: mechanistic insights. Gut 71, 1020–1032 (2022).
Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258–1270 (2012).
Article CAS PubMed PubMed Central Google Scholar
Brodin, P. Immune-microbe interactions early in life: a determinant of health and disease long term. Science 376, 945–950 (2022).
Article CAS PubMed Google Scholar
McFall-Ngai, M. et al. Animals in a bacterial world, a new imperative for the life sciences. Proc. Natl Acad. Sci. 110, 3229–3236 (2013).
Article CAS PubMed PubMed Central Google Scholar
Valdes, A. M., Walter, J., Segal, E. & Spector, T. D. Role of the gut microbiota in nutrition and health. BMJ 361, k2179 (2018).
Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369–2379 (2016).
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