Hotchkiss, R. S., Strasser, A., McDunn, J. E. & Swanson, P. E. Cell death. N. Engl. J. Med. 361, 1570–1583 (2009).
Article CAS PubMed PubMed Central Google Scholar
Galluzzi, L. et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25, 486–541 (2018).
Article PubMed PubMed Central Google Scholar
Querfurth, H. W. & LaFerla, F. M. Alzheimer’s disease. N. Engl. J. Med. 362, 329–344 (2010).
Article CAS PubMed Google Scholar
Green, D. R. The Coming Decade of Cell Death Research: Five Riddles. Cell 177, 1094–1107 (2019).
Article CAS PubMed PubMed Central Google Scholar
Wei, X. et al. Role of pyroptosis in inflammation and cancer. Cell Mol. Immunol. 19, 971–992 (2022).
Article CAS PubMed PubMed Central Google Scholar
Black, R. A., Kronheim, S. R. & Sleath, P. R. Activation of interleukin-1 beta by a co-induced protease. FEBS Lett. 247, 386–390 (1989).
Article CAS PubMed Google Scholar
Kostura, M. J. et al. Identification of a monocyte specific pre-interleukin 1 beta convertase activity. Proc. Natl Acad. Sci. USA 86, 5227–5231 (1989).
Article CAS PubMed PubMed Central Google Scholar
Yuan, J. et al. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75, 641–652 (1993).
Article CAS PubMed Google Scholar
Alnemri, E. S. et al. Human ICE/CED-3 protease nomenclature. Cell 87, 171 (1996).
Article CAS PubMed Google Scholar
Zychlinsky, A., Prevost, M. C. & Sansonetti, P. J. Shigella flexneri induces apoptosis in infected macrophages. Nature 358, 167–169 (1992).
Article CAS PubMed Google Scholar
Hersh, D. et al. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc. Natl Acad. Sci. USA 96, 2396–2401 (1999).
Article CAS PubMed PubMed Central Google Scholar
Brennan, M. A. & Cookson, B. T. Salmonella induces macrophage death by caspase-1-dependent necrosis. Mol. Microbiol. 38, 31–40 (2000).
Article CAS PubMed Google Scholar
Boise, L. H. & Collins, C. M. Salmonella-induced cell death: apoptosis, necrosis or programmed cell death? Trends Microbiol. 9, 64–67 (2001).
Article CAS PubMed Google Scholar
Man, S. M. & Kanneganti, T. D. Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat. Rev. Immunol. 16, 7–21 (2016).
Article CAS PubMed Google Scholar
Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10, 417–426 (2002).
Article CAS PubMed Google Scholar
Agostini, L. et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319–325 (2004).
Article CAS PubMed Google Scholar
Kayagaki, N. et al. Non-canonical inflammasome activation targets caspase-11. Nature 479, 117–121 (2011).
Article CAS PubMed Google Scholar
Kayagaki, N. et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341, 1246–1249 (2013).
Article CAS PubMed Google Scholar
Shi, J. et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660–665 (2015).
Article CAS PubMed Google Scholar
He, W. T. et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res 25, 1285–1298 (2015).
Article CAS PubMed PubMed Central Google Scholar
Kayagaki, N. et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666–671 (2015).
Article CAS PubMed Google Scholar
Ding, J. et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535, 111–116 (2016).
Article CAS PubMed Google Scholar
Wang, Y. et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547, 99–103 (2017).
Article CAS PubMed Google Scholar
Orning, P. et al. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science 362, 1064–1069 (2018).
Article CAS PubMed PubMed Central Google Scholar
Sarhan, J. et al. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc. Natl Acad. Sci. USA 115, E10888–e10897 (2018).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Z. et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 579, 415–420 (2020).
Article CAS PubMed PubMed Central Google Scholar
Zhou, Z. et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science 368, eaaz7548 (2020).
Article CAS PubMed Google Scholar
Deng, W. et al. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature 602, 496–502 (2022).
Article CAS PubMed PubMed Central Google Scholar
Zhong, X. et al. Structural mechanisms for regulation of GSDMB pore-forming activity. Nature 616, 598–605 (2023).
Article CAS PubMed Google Scholar
Strowig, T., Henao-Mejia, J., Elinav, E. & Flavell, R. Inflammasomes in health and disease. Nature 481, 278–286 (2012).
Article CAS PubMed Google Scholar
Zhu, C. et al. The gasdermin family: emerging therapeutic targets in diseases. Signal Transduct. Target Ther. 9, 87 (2024).
留言 (0)