Dahlhamer J, Lucas J, Zelaya C, Nahin R, Mackey S, DeBar L, Kerns R, Korff M (2018) Prevalence of chronic pain and high-impact chronic pain among adults - United States, 2016. MMWR Morb Mortal Wkly Rep 67(36):1001–1006. https://doi.org/10.15585/mmwr.mm6736a2

Article  PubMed  PubMed Central  Google Scholar 

Cohen SP, Vase L, Hooten WM (2021) Chronic pain: an update on burden, best practices, and new advances. Lancet (London, England) 397(10289):2082–2097. https://doi.org/10.1016/s0140-6736(21)00393-7

Article  PubMed  Google Scholar 

Boersma K, Södermark M, Hesser H, Flink IK, Gerdle B, Linton SJ (2019) Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial. Pain 160(8):1708–1718. https://doi.org/10.1097/j.pain.0000000000001575

Article  PubMed  PubMed Central  Google Scholar 

Carleton RN, Abrams MP, Asmundson GJ, Antony MM, McCabe RE (2009) Pain-related anxiety and anxiety sensitivity across anxiety and depressive disorders. J Anxiety Disord 23(6):791–798. https://doi.org/10.1016/j.janxdis.2009.03.003

Article  PubMed  Google Scholar 

Miettinen T, Sverloff J, Lappalainen OP, Linton SJ, Sipilä K, Kalso E (2022) Sleep problems in pain patients entering tertiary pain care: the role of pain-related anxiety, medication use, self-reported diseases, and sleep disorders. Pain 163(7):e812–e820. https://doi.org/10.1097/j.pain.0000000000002497

Article  PubMed  Google Scholar 

Malfliet A, Coppieters I, Van Wilgen P, Kregel J, De Pauw R, Dolphens M, Ickmans K (2017) Brain changes associated with cognitive and emotional factors in chronic pain: a systematic review. European J Pain (London, England) 21(5):769–786. https://doi.org/10.1002/ejp.1003

Article  CAS  Google Scholar 

Darnall BD, Roy A, Chen AL, Ziadni MS, Keane RT, You DS, Slater K, Poupore-King H et al (2021) Comparison of a single-session pain management skills intervention with a single-session health education intervention and 8 sessions of cognitive behavioral therapy in adults with chronic low back pain: a randomized clinical trial. JAMA Netw Open 4(8):e2113401. https://doi.org/10.1001/jamanetworkopen.2021.13401

Article  PubMed  PubMed Central  Google Scholar 

Gandy M, Pang STY, Scott AJ, Heriseanu AI, Bisby MA, Dudeney J, Karin E, Titov N et al (2022) Internet-delivered cognitive and behavioural based interventions for adults with chronic pain: a systematic review and meta-analysis of randomized controlled trials. Pain 163(10):e1041–e1053. https://doi.org/10.1097/j.pain.0000000000002606

Article  PubMed  Google Scholar 

Lee SH, Kang Y, Cho SJ (2017) Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality. J Headache Pain 18(1):77. https://doi.org/10.1186/s10194-017-0779-1

Article  PubMed  PubMed Central  Google Scholar 

Farmer AD, Holt CB, Downes TJ, Ruggeri E, Del Vecchio S, De Giorgio R (2018) Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol 3(3):203–212. https://doi.org/10.1016/s2468-1253(18)30008-6

Article  PubMed  Google Scholar 

Günther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R, Schulz S (2018) Targeting multiple opioid receptors - improved analgesics with reduced side effects? Br J Pharmacol 175(14):2857–2868. https://doi.org/10.1111/bph.13809

Article  CAS  PubMed  Google Scholar 

Bindu S, Mazumder S, Bandyopadhyay U (2020) Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol 180:114147. https://doi.org/10.1016/j.bcp.2020.114147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grosser T, Ricciotti E, FitzGerald GA (2017) The cardiovascular pharmacology of nonsteroidal anti-inflammatory drugs. Trends Pharmacol Sci 38(8):733–748. https://doi.org/10.1016/j.tips.2017.05.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng W, Zhang M (2009) Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density. Nat Rev Neurosci 10(2):87–99. https://doi.org/10.1038/nrn2540

Article  CAS  PubMed  Google Scholar 

Li A, Huang CJ, Gu KP, Huang Y, Huang YQ, Zhang H, Lin JP, Liu YF et al (2022) PSD-95 in the anterior cingulate cortex contributes to neuropathic pain by interdependent activation with NR2B. Sci Rep 12(1):17114. https://doi.org/10.1038/s41598-022-21488-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Dai L, Xu D, Wang Y, Bai L, Chen X, Li M, Yang S et al (2022) Astrocyte secretes IL-6 to modulate PSD-95 palmitoylation in basolateral amygdala and depression-like behaviors induced by peripheral nerve injury. Brain Behav Immun 104:139–154. https://doi.org/10.1016/j.bbi.2022.05.014

Article  CAS  PubMed  Google Scholar 

Zhu YB, Jia GL, Wang JW, Ye XY, Lu JH, Chen JL, Zhang MB, Xie CS et al (2020) Activation of CaMKII and GluR1 by the PSD-95-GluN2B coupling-dependent phosphorylation of GluN2B in the spinal cord in a rat model of type-2 diabetic neuropathic pain. J Neuropathol Exp Neurol 79(7):800–808. https://doi.org/10.1093/jnen/nlaa035

Article  CAS  PubMed  Google Scholar 

D’Mello R, Marchand F, Pezet S, McMahon SB, Dickenson AH (2011) Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain. Mol Ther: J Am Soc Gene Ther 19(10):1780–1792. https://doi.org/10.1038/mt.2011.42

Article  CAS  Google Scholar 

Cai W, Wu S, Pan Z, Xiao J, Li F, Cao J, Zang W, Tao YX (2018) Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain. Neuropharmacology 141:238–248. https://doi.org/10.1016/j.neuropharm.2018.09.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Pan Q, Tian R, Wen Q, Qin G, Zhang D, Chen L, Zhang Y et al (2021) Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model. J Headache Pain 22(1):84. https://doi.org/10.1186/s10194-021-01299-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lim IA, Hall DD, Hell JW (2002) Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem 277(24):21697–21711. https://doi.org/10.1074/jbc.M112339200

Article  CAS  PubMed  Google Scholar 

Dev KK (2004) Making protein interactions druggable: targeting PDZ domains. Nat Rev Drug Discovery 3(12):1047–1056. https://doi.org/10.1038/nrd1578

Article  CAS  PubMed  Google Scholar 

Kim E, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5(10):771–781. https://doi.org/10.1038/nrn1517

Article  CAS  PubMed  Google Scholar 

Kim E, Naisbitt S, Hsueh YP, Rao A, Rothschild A, Craig AM, Sheng M (1997) GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J Cell Biol 136(3):669–678. https://doi.org/10.1083/jcb.136.3.669

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, Scott JD (2000) Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27(1):107–119. https://doi.org/10.1016/s0896-6273(00)00013-1

Article  CAS  PubMed  Google Scholar 

Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (2001) Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31(2):289–303. https://doi.org/10.1016/s0896-6273(01)00355-5

Article  CAS  PubMed  Google Scholar 

Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (New York, NY) 269(5231):1737–1740. https://doi.org/10.1126/science.7569905