Synthesis of Unsymmetrical 2,4-Diaryl Substituted and 3-Bromo-2-(4-bromoalkoxy)-Derived Pyranocoumarins

A series of unsymmetrical 2,4-disubstituted pyranocoumarins and 3-bromo-2-(4-bromoalkoxy)-derived pyranocoumarins were synthesized via the palladium-catalyzed C-H arylation of 4-phenyl-4H,5H-pyrano[3,2-c]chromen-5-ones with aryl iodide and the three-component reaction of 4-phenyl-4H,5H-pyrano[3,2-c]chromen-5-one with bromine and cyclic ether, respectively.

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