Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice

Oladunni FS, Park J-G, Pino PA, Gonzalez O, Akhter A, Allué-Guardia A, et al. Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice. Nat Commun. 2020;11:6122.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Souza TML, Pinho VD, Setim CF, Sacramento CQ, Marcon R, Fintelman-Rodrigues N, et al. Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation. Nat Commun. 2023;14:199.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yinda CK, Port JR, Bushmaker T, Offei Owusu I, Purushotham JN, Avanzato VA, et al. K18-hACE2 mice develop respiratory disease resembling severe COVID-19. PLoS Pathog. 2021;17:e1009195.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Janiuk K, Jabłońska E, Garley M. Significance of NETs formation in COVID-19. Cells. 2021;10:151.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gonzalez-Mosquera LF, Gomez-Paz S, Lam E, Cardenas-Maldonado D, Fogel J, Adi V, et al. Hematologic involvement as a predictor of Mortality in COVID-19 patients in a Safety Net Hospital. Kans J Med. 2022;15:8–16.

PubMed  PubMed Central  Google Scholar 

Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of Immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020;71:762–8.

Article  PubMed  CAS  Google Scholar 

Jafarzadeh A, Jafarzadeh S, Nozari P, Mokhtari P, Nemati M. Lymphopenia an important immunological abnormality in patients with COVID-19: possible mechanisms. Scand J Immunol. 2021;93:e12967.

Article  PubMed  CAS  Google Scholar 

Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang Y-Q, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduct Target Ther. 2020;5:33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu B, Fan C-Y, Wang A-L, Zou Y-L, Yu Y-H, He C, et al. Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China. J Infect. 2020;81:e51–60.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Santos RAS, Oudit GY, Verano-Braga T, Canta G, Steckelings UM, Bader M. The renin-angiotensin system: going beyond the classical paradigms. Am J Physiol Heart Circ Physiol. 2019;316:H958–70.

Article  PubMed  PubMed Central  Google Scholar 

Tavares LP, Melo EM, Sousa LP, Teixeira MM. Pro-resolving therapies as potential adjunct treatment for infectious diseases: evidence from studies with annexin A1 and angiotensin-(1–7). Semin Immunol. 2022;59:101601.

Article  PubMed  CAS  Google Scholar 

Costa VV, Resende F, Melo EM, Teixeira MM. Resolution pharmacology and the treatment of infectious diseases. Br J Pharmacol. 2024;181:917–37.

Article  PubMed  CAS  Google Scholar 

Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436:112–6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Melo EM, Del Sarto J, Vago JP, Tavares LP, Rago F, Gonçalves APF, et al. Relevance of angiotensin-(1–7) and its receptor mas in pneumonia caused by influenza virus and post-influenza pneumococcal infection. Pharmacol Res. 2021;163:105292.

Article  PubMed  CAS  Google Scholar 

Yang P, Gu H, Zhao Z, Wang W, Cao B, Lai C, et al. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 2014;4:7027.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zou Z, Yan Y, Shu Y, Gao R, Sun Y, Li X, et al. Angiotensin-converting enzyme 2 protects from lethal avian influenza a H5N1 infections. Nat Commun. 2014;5:3594.

Article  PubMed  CAS  Google Scholar 

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–e2808.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong J-C, Turner AJ, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and Regulator of the renin-angiotensin system: celebrating the 20th anniversary of the Discovery of ACE2. Circ Res. 2020;126:1456–74.

Article  PubMed  CAS  Google Scholar 

Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46:586–90.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Braz-de-Melo HA, Faria SS, Pasquarelli-do-Nascimento G, Santos I, de O, Kobinger GP, Magalhães KG. The Use of the anticoagulant heparin and corticosteroid dexamethasone as prominent treatments for COVID-19. Front Med (Lausanne). 2021;8:615333.

Article  PubMed  PubMed Central  Google Scholar 

Chen Z, Yuan Y, Hu Q, Zhu A, Chen F, Li S, et al. SARS-CoV-2 immunity in animal models. Cell Mol Immunol. 2024;21:119–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Andrade ACDSP, Campolina-Silva GH, Queiroz-Junior CM, de Oliveira LC, Lacerda L, de Pimenta SB. A Biosafety Level 2 mouse model for studying Betacoronavirus-Induced Acute Lung damage and systemic manifestations. J Virol. 2021;95:e0127621.

Article  PubMed  Google Scholar 

Pereira Rdas, Rabelo D, Oliveira RAN, de Porto NF, Andrade SLT, Queiroz-Junior ACDSP. A 5-Lipoxygenase inhibitor, Zileuton, modulates host Immune responses and improves lung function in a model of severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus. Viruses. 2023;15:2049.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Oliveira VLS, Queiroz-Junior CM, Hoorelbeke D, Santos FR, da Chaves S, de Teixeira I et al. MM,. The glycosaminoglycan-binding chemokine fragment CXCL9(74–103) reduces inflammation and tissue damage in mouse models of coronavirus infection. Front Immunol [Internet]. 2024 [cited 2024 Jun 1];15. Available from.

Tsai H-J, Liao M-H, Shih C-C, Ka S-M, Tsao C-M, Wu C-C. Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Crit Care. 2018;22:269.

Article  PubMed  PubMed Central  Google Scholar 

Collins KL, Younis US, Tanyaratsrisakul S, Polt R, Hay M, Mansour HM, et al. Angiotensin-(1–7) peptide hormone reduces inflammation and Pathogen Burden during Mycoplasma pneumoniae infection in mice. Pharmaceutics. 2021;13:1614.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sousa LP, Pinho V, Teixeira MM. Harnessing inflammation resolving-based therapeutic agents to treat pulmonary viral infections: what can the future offer to COVID-19? Br J Pharmacol. 2020;177:3898–904.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peiró C, Moncada S. Substituting Angiotensin-(1–7) to prevent lung damage in SARS-CoV-2 infection? Circulation. 2020;141:1665–6.

Article  PubMed  PubMed Central  Google Scholar 

Shete A. Urgent need for evaluating agonists of angiotensin-(1–7)/Mas receptor axis for treating patients with COVID-19. Int J Infect Dis. 2020;96:348–51.

Article  PubMed  PubMed Central  CAS 

留言 (0)

沒有登入
gif