Corynoline alleviates hepatic ischemia–reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling

Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. Ischaemia-reperfusion injury in liver transplantation–from bench to bedside. Nat Rev Gastroenterol Hepatol. 2013;10:79–89. https://doi.org/10.1038/nrgastro.2012.225.

Article  CAS  PubMed  Google Scholar 

Peralta C, Jiménez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu. J Hepatol. 2013;59:1094–106. https://doi.org/10.1016/j.jhep.2013.06.017.

Article  PubMed  Google Scholar 

Vardanian AJ, Busuttil RW, Kupiec-Weglinski JW. Molecular mediators of liver ischemia and reperfusion injury: a brief review. Mol Med. 2008;14:337–45. https://doi.org/10.2119/2007-00134.Vardanian.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Golen RF, Reiniers MJ, Olthof PB, van Gulik TM, Heger M. Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics. J Gastroenterol Hepatol. 2013;28:394–400. https://doi.org/10.1111/jgh.12072.

Article  CAS  PubMed  Google Scholar 

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018;17:588–606. https://doi.org/10.1038/nrd.2018.97.

Article  CAS  PubMed  Google Scholar 

Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M. NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. J Immunol. 2014;192:4342–51. https://doi.org/10.4049/jimmunol.1302039.

Article  CAS  PubMed  Google Scholar 

Xu Y, Tang Y, Lu J, Zhang W, Zhu Y, Zhang S, Ma G, Jiang P, Zhang W. PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation. Free Radic Biol Med. 2020;160:871–86. https://doi.org/10.1016/j.freeradbiomed.2020.09.015.

Article  CAS  PubMed  Google Scholar 

Martinon F. Signaling by ROS drives inflammasome activation. Eur J Immunol. 2010;40:616–9. https://doi.org/10.1002/eji.200940168.

Article  CAS  PubMed  Google Scholar 

He Y, Hara H, Núñez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41:1012–21. https://doi.org/10.1016/j.tibs.2016.09.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harijith A, Ebenezer DL, Natarajan V. Reactive oxygen species at the crossroads of inflammasome and inflammation. Front Physiol. 2014;5:352. https://doi.org/10.3389/fphys.2014.00352.

Article  PubMed  PubMed Central  Google Scholar 

Elias-Miró M, Jiménez-Castro MB, Rodés J, Peralta C. Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radic Res. 2013;47:555–68. https://doi.org/10.3109/10715762.2013.811721.

Article  CAS  PubMed  Google Scholar 

Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev. 2006;38:769–89. https://doi.org/10.1080/03602530600971974.

Article  CAS  PubMed  Google Scholar 

Bellezza I, Giambanco I, Minelli A, Donato R. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 2018;1865:721–33. https://doi.org/10.1016/j.bbamcr.2018.02.010.

Article  CAS  PubMed  Google Scholar 

Du P, Zhang X, Luo K, Li Y, Fu C, Xiao J, Xiao Q. Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway. Hum Exp Toxicol. 2022;41:9603271221087146. https://doi.org/10.1177/09603271221087146.

Article  CAS  PubMed  Google Scholar 

Hennig P, Garstkiewicz M, Grossi S, Di Filippo M, French LE, Beer HD. The crosstalk between Nrf2 and inflammasomes. Int J Mol Sci. 2018. https://doi.org/10.3390/ijms19020562.

Article  PubMed  PubMed Central  Google Scholar 

Luo X, Sun D, Wang Y, Zhang F, Wang Y. Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway. Can J Physiol Pharmacol. 2021;99:468–77. https://doi.org/10.1139/cjpp-2020-0165.

Article  CAS  PubMed  Google Scholar 

Xu X, Zhang L, Ye X, Hao Q, Zhang T, Cui G, Yu M. Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion. Inflamm Res. 2018;67:57–65. https://doi.org/10.1007/s00011-017-1095-6.

Article  CAS  PubMed  Google Scholar 

Yang C, Zhang C, Wang Z, Tang Z, Kuang H, Kong AN. Corynoline isolated from corydalis bungeana. Turcz exhibits anti-inflammatory effects via modulation of Nfr2 and MAPKs. Molecules. 2016. https://doi.org/10.3390/molecules21080975.

Article  PubMed  PubMed Central  Google Scholar 

Weng W, Wang F, He X, Zhou K, Wu X, Wu X. Protective effect of Corynoline on the CFA induced Rheumatoid arthritis via attenuation of oxidative and inflammatory mediators. Mol Cell Biochem. 2021;476:831–9. https://doi.org/10.1007/s11010-020-03948-8.

Article  CAS  PubMed  Google Scholar 

Yi C, Li X, Chen S, Liu M, Lu W, Ye X. Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress. Phytother Res. 2020;34:2766–77. https://doi.org/10.1002/ptr.6719.

Article  CAS  PubMed  Google Scholar 

Liu Y, Song M, Zhu G, Xi X, Li K, Wu C, Huang L. Corynoline attenuates LPS-induced acute lung injury in mice by activating Nrf2. Int Immunopharmacol. 2017;48:96–101. https://doi.org/10.1016/j.intimp.2017.04.029.

Article  CAS  PubMed  Google Scholar 

Liu B, Su K, Wang J, Wang J, Xin Z, Li F, Fu Y. Corynoline exhibits anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells through activating Nrf2. Inflammation. 2018;41:1640–7. https://doi.org/10.1007/s10753-018-0807-6.

Article  CAS  PubMed  Google Scholar 

Wu Y, He T, Fu Y, Chen J. Corynoline protects lipopolysaccharide-induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway. Environ Toxicol. 2021;36:2493–9. https://doi.org/10.1002/tox.23362.

Article  CAS  PubMed  Google Scholar 

Li S, Shi Y, Zhang S, Li H, Ye Z, Kong J, Hong W, Tu Y, Ren J, Meftah Z, Xie C, Wang X, Zhang X. Corynoline alleviates osteoarthritis development via the Nrf2/NF-κB Pathway. Oxid Med Cell Longev. 2022;2022:2188145. https://doi.org/10.1155/2022/2188145.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Lang W, Li S, Xu C, Wang X, Li Y, Zhang Z, Wu T, Feng M. Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway. Immunopharmacol Immunotoxicol. 2023;45:26–34. https://doi.org/10.1080/08923973.2022.2112218.

Article  CAS  PubMed  Google Scholar 

Sun L, He D, Liu Y, Wei Y, Wang L. Corynoline protects against zearalenone-induced liver injury by activating the SIRT1/Nrf2 signaling pathway. J Biochem Mol Toxicol. 2023;37:e23224. https://doi.org/10.1002/jbt.23224.

Article  CAS  PubMed  Google Scholar 

Cho WH, Kim DG, Murase N, Mischinger HJ, Todo S, Starzl TE. Comparison of superoxide dismutase, allopurinol, coenzyme Q10, and glutathione for the prevention of warm ischemic injury. Transplantation. 1990;50:353–5.

CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif