The correlation of inflammation, tryptophan-kynurenine pathway, and suicide risk in adolescent depression

Patel V et al (2007) Mental health of young people: a global public-health challenge. The Lancet 369(9569):1302–1313

Article  Google Scholar 

Fu X, Zhang K (2023) China’s National Mental Health Development Report. 2021–2022. Social Science Literature Publishing House

Mojtabai R, Olfson M, Han B (2016) National trends in the prevalence and treatment of depression in adolescents and young adults. Pediatrics 138(6)

Barberio B et al (2021) Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 6(5):359–370

Article  PubMed  Google Scholar 

Nerurkar L et al (2019) Rheumatoid arthritis and depression: an inflammatory perspective. Lancet Psychiat 6(2):164–173

Article  Google Scholar 

Maes M et al (2011) Depression’s multiple comorbidities explained by (neuro) inflammatory and oxidative & nitrosative stress pathways. Neuroendocrinol Lett 32(1):7–24

CAS  PubMed  Google Scholar 

Das R et al (2021) Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder. Psychiat Res 295:113568

Article  CAS  Google Scholar 

Dowlati Y et al (2010) A meta-analysis of cytokines in major depression. Biol Psychiat 67(5):446–457

Article  CAS  PubMed  Google Scholar 

Drevets WC et al (2022) Immune targets for therapeutic development in depression: towards precision medicine. Nat Rev Drug Discovery 21(3):224–244

Article  CAS  PubMed  Google Scholar 

Mac Giollabhui N et al (2021) The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression. Mol Psychiat 26(7):3302–3314

Article  CAS  Google Scholar 

Karlović D et al (2012) Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features. Psychiat Res 198(1):74–80

Article  Google Scholar 

Lamers F et al (2019) Longitudinal association between depression and inflammatory markers: results from the Netherlands study of depression and anxiety. Biol Psychiat 85(10):829–837

Article  PubMed  Google Scholar 

Capuron L, Miller AH (2004) Cytokines and psychopathology: lessons from interferon-α. Biol Psychiat 56(11):819–824

Article  CAS  PubMed  Google Scholar 

Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27(1):24–31

Article  CAS  PubMed  Google Scholar 

Savitz J (2020) The kynurenine pathway: a finger in every pie. Mol Psychiat 25(1):131–147

Article  Google Scholar 

Cervenka I, Agudelo LZ, Ruas JL (2017) Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health. Science 357(6349):eaaf794

Article  Google Scholar 

Savitz J (2017) Role of kynurenine metabolism pathway activation in major depressive disorders. Inflammation-associated depression: Evidence, mechanisms and implications. p. 249–267

Marx W et al (2021) The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies. Mol Psychiat 26(8):4158–4178

Article  CAS  Google Scholar 

Tanaka M et al (2021) Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway. Biomedicines 9(7):734

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bryleva EY, Brundin L (2017) Kynurenine pathway metabolites and suicidality. Neuropharmacology 112:324–330

Article  CAS  PubMed  Google Scholar 

Miura H et al (2008) A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress 11(3):198–209

Article  CAS  PubMed  Google Scholar 

Réus GZ et al (2015) Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies. J Psychiatr Res 68:316–328

Article  PubMed  PubMed Central  Google Scholar 

Myint AM, Kim YK (2003) Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med Hypotheses 61(5–6):519–525

Article  CAS  PubMed  Google Scholar 

Parrott J et al (2016) Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Transl Psychiat 6(10):e918–e918

Article  CAS  Google Scholar 

Bay-Richter C et al (2015) A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. Brain Behav Immun 43:110–117

Article  CAS  PubMed  Google Scholar 

Erhardt S et al (2013) Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 38(5):743–752

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torres-Platas SG et al (2014) Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun 42:50–59

Article  CAS  PubMed  Google Scholar 

Pandey GN (2017) Inflammatory and innate immune markers of neuroprogression in depressed and teenage suicide brain, in Neuroprogression in psychiatric disorders. Karger Publishers. p. 79–95

Steiner J et al (2011) Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflamm 8:1–9

Article  Google Scholar 

Busse M et al (2015) Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses? Eur Arch Psychiat Clin Neurosci 265:321–329

Article  Google Scholar 

Heron MP (2021) Deaths: leading causes for 2018

Bradley KA et al (2015) The role of the kynurenine pathway in suicidality in adolescent major depressive disorder. Psychiat Res 227(2–3):206–212

Article  CAS  Google Scholar 

Messaoud A et al. (2018) Reduced peripheral availability of tryptophan and increased activation of the kynurenine pathway and cortisol correlate with major depression and suicide. World J Biol Psychiat

Sublette ME et al (2011) Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun 25(6):1272–1278

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gabbay V et al (2009) A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression. J Child Adolesc Psychopharmacol 19(4):423–430

Article  PubMed  PubMed Central  Google Scholar 

O’Donovan A et al (2013) Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress Anxiety 30(4):307–314

Article  PubMed  Google Scholar 

Janelidze S et al (2011) Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun 25(2):335–339

Article  CAS  PubMed  Google Scholar 

Ferencova N et al (2023) Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression. J Inflamm Res 15:5959–5976

Article  Google Scholar 

Badawy AA, Guillemin G (2019) The plasma [kynurenine]/[tryptophan] ratio and indoleamine 2, 3-dioxygenase: time for appraisal. Int J Tryptophan Res 12:1178646919868978

Article  PubMed  PubMed Central  Google Scholar 

Dantzer R (2017) Role of the kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches. Inflammation-associated depression: Evidence, mechanisms and implications, p. 117–138

Himmerich H et al (2019) Cytokine research in depression: principles, challenges, and open questions. Front Psych 10:30

Article  Goo

留言 (0)

沒有登入
gif