D.J. Magliano, E.J. Boyko, committee IDAtes. International Diabetes Federation; 2021. 10th ed. Brussels.2021.

I.S. Thrainsdottir, T. Aspelund, T. Hardarson, K. Malmberg, G. Sigurdsson, G. Thorgeirsson et al. Glucose abnormalities and heart failure predict poor prognosis in the population-based Reykjavik Study. Eur. J. Cardiovasc Prev. Rehabil. 12, 465–471 (2005)

Article  PubMed  Google Scholar 

J.B. Buse, D.J. Wexler, A. Tsapas, P. Rossing, G. Mingrone, C. Mathieu et al. 2019 Update to: Management of hyperglycemia in type 2 diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diab. Care 43, 487–493 (2020)

Article  CAS  Google Scholar 

R.I. Misbin, L. Green, B.V. Stadel, J.L. Gueriguian, A. Gubbi, G.A. Fleming, Lactic acidosis in patients with diabetes treated with metformin. N. Engl. J. Med. 338, 265–266 (1998)

Article  PubMed  CAS  Google Scholar 

S.E. Inzucchi, F.A. Masoudi, D.K. McGuire, Metformin in heart failure. Diab. Care 30, e129 (2007)

Article  Google Scholar 

A.A. Tahrani, G.I. Varughese, J.H. Scarpello, F.W. Hanna, Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated? BMJ 335, 508–512 (2007)

Article  PubMed  PubMed Central  CAS  Google Scholar 

A. Holstein, E.H. Egberts, [Traditional contraindications to the use of metformin – more harmful than beneficial?]. Dtsch Med Wochenschr. 131, 105–110 (2006)

Article  PubMed  CAS  Google Scholar 

J.N. Cohn, R. Ferrari, N. Sharpe, Cardiac remodeling–concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J. Am. Coll. Cardiol. 35, 569–582 (2000)

Article  PubMed  CAS  Google Scholar 

M.R. MacDonald, M.C. Petrie, N.M. Hawkins, J.R. Petrie, M. Fisher, R. McKelvie et al. Diabetes, left ventricular systolic dysfunction, and chronic heart failure. Eur. Heart J. 29, 1224–1240 (2008)

Article  PubMed  CAS  Google Scholar 

G. Wells, B. Shea, D. O’Connell, J. Peterson, V. Welch, M. Losos et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

R. Harris, J. Deeks, D. Altman, M. Bradburn, R. Harbord, J. Sterne, Metan: fixed- and random-effects meta-analysis. Stata J. 8, 3–28 (2008)

Article  Google Scholar 

V. Nyaga, M. Arbyn, M. Aerts, Metaprop: a Stata command to perform meta-analysis of binomial data. Arch. Public Health 72, 39 (2014)

Article  PubMed  PubMed Central  Google Scholar 

M. Egger, Davey, G. Smith, M. Schneider, Bias in meta-analysis detected by a simple, graphical test. Br. Med. J. 315, 629–634 (1997)

Article  CAS  Google Scholar 

S. Duval, R. Tweedie, Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56, 455–463 (2000)

Article  PubMed  CAS  Google Scholar 

R. Roussel, F. Travert, B. Pasquet, P.W. Wilson, S.C. Smith Jr., S. Goto et al. Metformin use and mortality among patients with diabetes and atherothrombosis. Arch. Intern Med 170, 1892–1899 (2010)

Article  PubMed  CAS  Google Scholar 

P. Liu, X.C. Zhou, T. Wang, Clinical study of Dapagliflozin in the treatment of type 2 diabetes complicated with heart failure. Chin. J. Clin. Pharmacol. 37, 227–230 (2021)

Google Scholar 

R.F. Hua, Q. Shu, Y. Liu, X.B. Zeng, L. Ji, B.Q. Xie et al. Efficacy of sitagliptin metformin combination with insulin in the treatment of obesity type 2 diabetes with heart failure. Shanghai Med. J. 37, 862–864 (2014)

CAS  Google Scholar 

Y. Su, D. Wang, J. Long, F. Yang, Q. Xu, L.Y. Si, Clinical study of Metformin improving cardiac function in patients with type 2 diabetes complicated with diastolic heart failure. J. Third Mil. Med. Univ. 35, 1862–1865 (2013)

CAS  Google Scholar 

C. Andersson, J.B. Olesen, P.R. Hansen, P. Weeke, M.L. Norgaard, C.H. Jorgensen et al. Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study. Diabetologia 53, 2546–2553 (2010)

Article  PubMed  CAS  Google Scholar 

J. Wang, Y. Lu, X. Min, T. Yuan, J. Wei, Z. Cai, The association between metformin treatment and outcomes in type 2 diabetes mellitus patients with heart failure with preserved ejection fraction: A retrospective study. Front Cardiovasc Med 8, 648212 (2021)

Article  PubMed  PubMed Central  CAS  Google Scholar 

A. Retwinski, M. Kosmalski, M. Crespo-Leiro, A. Maggioni, G. Opolski, P. Ponikowski et al. The influence of metformin and the presence of type 2 diabetes mellitus on mortality and hospitalisation in patients with heart failure. Kardiol. Pol. 76, 1336–1343 (2018)

Article  PubMed  Google Scholar 

H.Y. Chang, Y.W. Su, A.N. Feng, M.C. Fong, K.C. Huang, E. Chong et al. Prescription patterns of diabetes medications influencing clinical outcomes of heart failure patients with reduced ejection fraction. ESC Heart Fail 7, 604–615 (2020)

Article  PubMed  PubMed Central  Google Scholar 

F.A. Masoudi, S.E. Inzucchi, Y. Wang, E.P. Havranek, J.M. Foody, H.M. Krumholz, Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 111, 583–590 (2005)

Article  PubMed  CAS  Google Scholar 

D.T. Eurich, S.R. Majumdar, F.A. McAlister, R.T. Tsuyuki, J.A. Johnson, Improved clinical outcomes associated with metformin in patients with diabetes and heart failure. Diab. Care 28, 2345–2351 (2005)

Article  CAS  Google Scholar 

J.M. Evans, A.S. Doney, M.A. AlZadjali, S.A. Ogston, J.R. Petrie, A.D. Morris et al. Effect of Metformin on mortality in patients with heart failure and type 2 diabetes mellitus. Am. J. Cardiol. 106, 1006–1010 (2010)

Article  PubMed  CAS  Google Scholar 

J. Benes, M. Kotrc, K. Kroupova, P. Wohlfahrt, J. Kovar, J. Franekova et al. Metformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF). Sci. Rep. 12, 13038 (2022)

Article  PubMed  PubMed Central  CAS  Google Scholar 

T.R. Godec, D.I. Bromage, M. Pujades-Rodriguez, A. Cannata, A. Gonzalez-Izquierdo, S. Denaxas et al. Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure. ESC Heart Fail 9, 1608–1615 (2022)

Article  PubMed  PubMed Central  Google Scholar 

D. Aguilar, W. Chan, B. Bozkurt, K. Ramasubbu, A. Deswal, Metformin use and mortality in ambulatory patients with diabetes and heart failure. Circ. Heart Fail 4, 53–58 (2011)

Article  PubMed  CAS  Google Scholar 

D.D. Shah, G.C. Fonarow, T.B. Horwich, Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes. J. Card. Fail 16, 200–206 (2010)

Article  PubMed  CAS  Google Scholar 

Group UPDS, Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352, 854–865 (1998)

Article  Google Scholar 

L. Facila, O. Fabregat-Andres, V. Bertomeu, J.P. Navarro, G. Minana, S. Garcia-Blas et al. Metformin and risk of long-term mortality following an admission for acute heart failure. J. Cardiovasc Med (Hagerstown) 18, 69–73 (2017)

Article  PubMed  CAS  Google Scholar 

A. Halabi, J. Sen, Q. Huynh, T.H. Marwick, Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis. Cardiovasc Diabetol. 19, 124 (2020)

Article  PubMed  PubMed Central  CAS  Google Scholar 

G. Rena, E.R. Pearson, K. Sakamoto, Molecular mechanism of action of metformin: old or new insights? Diabetologia 56, 1898–1906 (2013)

Article  PubMed  PubMed Central  CAS  Google Scholar 

X.F. Wang, J.Y. Zhan