Agha M, Agha R. The rising prevalence of obesity: part A: impact on public health. IJS Oncol. 2017;2: e17. https://doi.org/10.1097/IJ9.0000000000000017.

Google Scholar 

Bluher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15:288–9. https://doi.org/10.1038/s41574-019-0176-8.

PubMed  Google Scholar 

Sanyaolu A, Okorie C, Qi X, Locke J, Rehman S. Childhood and Adolescent Obesity in the United States: A Public Health Concern. Glob Pediatr Health 2019;6:2333794X19891305. https://doi.org/10.1177/2333794X19891305.

Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in Obesity Among Adults in the United States, 2005 to 2014. JAMA. 2016;315:2284–91. https://doi.org/10.1001/jama.2016.6458.

PubMed  PubMed Central  Google Scholar 

Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of Childhood and Adult Obesity in the United States, 2011–2012. JAMA. 2014;311:806–14. https://doi.org/10.1001/jama.2014.732.

PubMed  PubMed Central  Google Scholar 

Hales CM, Fryar CD, Carroll MD, Freedman DS, Ogden CL. Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007–2008 to 2015–2016. JAMA. 2018;319:1723–5. https://doi.org/10.1001/jama.2018.3060.

PubMed  PubMed Central  Google Scholar 

Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med 2017;5:161. https://doi.org/10.21037/atm.2017.03.107.

Flegal KM, Williamson DF, Pamuk ER, Rosenberg HM. Estimating Deaths Attributable to Obesity in the United States. Am J Public Health. 2004;94:1486–9.

PubMed  PubMed Central  Google Scholar 

World Health Organization. Obesity and overweight. Obes Overweight - Fact Sheets 2021. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed March 30, 2023).

World Obesity Federation. The World Obesity Atlas 2023. https://www.worldobesityday.org/policy-makers (accessed February 14, 2023).

Restrepo BJ. Obesity Prevalence Among U.S. Adults During the COVID-19 Pandemic. Am J Prev Med. 2022;63:102–6. https://doi.org/10.1016/j.amepre.2022.01.012.

PubMed  PubMed Central  Google Scholar 

Spiegelman BM, Flier JS. Obesity and the Regulation of Energy Balance. Cell. 2001;104:531–43. https://doi.org/10.1016/S0092-8674(01)00240-9.

PubMed  Google Scholar 

de Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem. 2008;54:945–55. https://doi.org/10.1373/clinchem.2007.100156.

PubMed  Google Scholar 

Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL. The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol. 2013;169:1–8. https://doi.org/10.1111/bjd.12208.

PubMed  PubMed Central  Google Scholar 

Bornstein R, Gonzalez B, Johnson SC. Mitochondrial pathways in human health and aging. Mitochondrion. 2020;54:72–84. https://doi.org/10.1016/j.mito.2020.07.007.

PubMed  PubMed Central  Google Scholar 

Heinonen S, Buzkova J, Muniandy M, Kaksonen R, Ollikainen M, Ismail K, et al. Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity. Diabetes. 2015;64:3135–45. https://doi.org/10.2337/db14-1937.

PubMed  Google Scholar 

Lindinger A, Peterli R, Peters T, Kern B, von Flüe M, Calame M, et al. Mitochondrial DNA content in human omental adipose tissue. Obes Surg. 2010;20:84–92. https://doi.org/10.1007/s11695-009-9987-3.

PubMed  Google Scholar 

Rautenberg EK, Hamzaoui Y, Coletta DK. Mini-review: Mitochondrial DNA methylation in type 2 diabetes and obesity. Front Endocrinol. 2022;13: 968268. https://doi.org/10.3389/fendo.2022.968268.

Google Scholar 

Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72:694–701. https://doi.org/10.1093/ajcn/72.3.694.

PubMed  Google Scholar 

Lemos T, Gallagher D. Current body composition measurement techniques. Curr Opin Endocrinol Diabetes Obes. 2017;24:310–4. https://doi.org/10.1097/MED.0000000000000360.

PubMed  PubMed Central  Google Scholar 

Gallagher D, Andres A, Fields DA, Evans WJ, Kuczmarski R, Lowe WL, et al. Body Composition Measurements from Birth through 5 Years: Challenges, Gaps, and Existing & Emerging Technologies—A National Institutes of Health workshop. Obes Rev Off J Int Assoc Study Obes. 2020;21: e13033. https://doi.org/10.1111/obr.13033.

Google Scholar 

Cypess AM. Reassessing Human Adipose Tissue. N Engl J Med. 2022;386:768–79. https://doi.org/10.1056/NEJMra2032804.

PubMed  Google Scholar 

Gallagher D, Kuznia P, Heshka S, Albu J, Heymsfield SB, Goodpaster B, et al. Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr. 2005;81:903–10.

PubMed  Google Scholar 

Yim J-E, Heshka S, Albu JB, Heymsfield S, Gallagher D. Femoral-gluteal subcutaneous and intermuscular adipose tissues have independent and opposing relationships with CVD risk. J Appl Physiol. 2008;104:700–7. https://doi.org/10.1152/japplphysiol.01035.2007.

PubMed  Google Scholar 

Gallagher D, Kelley DE, Yim J-E, Spence N, Albu J, Boxt L, et al. Adipose tissue distribution is different in type 2 diabetes2. Am J Clin Nutr. 2009;89:807–14. https://doi.org/10.3945/ajcn.2008.26955.

PubMed  PubMed Central  Google Scholar 

Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metab. 2018;27:68–83. https://doi.org/10.1016/j.cmet.2017.12.002.

PubMed  PubMed Central  Google Scholar 

Gallagher D, Heshka S, Kelley DE, Thornton J, Boxt L, Pi-Sunyer FX, et al. Changes in Adipose Tissue Depots and Metabolic Markers Following a 1-Year Diet and Exercise Intervention in Overweight and Obese Patients With Type 2 Diabetes. Diabetes Care. 2014;37:3325–32. https://doi.org/10.2337/dc14-1585.

PubMed  PubMed Central  Google Scholar 

Toro-Ramos T, Goodpaster BH, Janumala I, Lin S, Strain GW, Thornton JC, et al. Continued Loss in Visceral and Intermuscular Adipose Tissue in Weight-Stable Women Following Bariatric Surgery. Obes Silver Spring Md. 2015;23:62–9. https://doi.org/10.1002/oby.20932.

Google Scholar 

Saely CH, Geiger K, Drexel H. Brown versus white adipose tissue: a mini-review. Gerontology. 2012;58:15–23. https://doi.org/10.1159/000321319.

PubMed  Google Scholar 

Zhu Q, An YA, Scherer PE. Mitochondrial regulation and white adipose tissue homeostasis. Trends Cell Biol. 2022;32:351–64. https://doi.org/10.1016/j.tcb.2021.10.008.

PubMed  Google Scholar 

Giralt M, Villarroya F. White, Brown, Beige/Brite: Different Adipose Cells for Different Functions? Endocrinology. 2013;154:2992–3000. https://doi.org/10.1210/en.2013-1403.

PubMed  Google Scholar 

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and Importance of Brown Adipose Tissue in Adult Humans. N Engl J Med. 2009;360:1509–17. https://doi.org/10.1056/NEJMoa0810780.

PubMed  PubMed Central  Google Scholar 

Pfannenberg C, Werner MK, Ripkens S, Stef I, Deckert A, Schmadl M, et al. Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans. Diabetes. 2010;59:1789–93. https://doi.org/10.2337/db10-0004.

PubMed  PubMed Central  Google Scholar 

Abernathy RP, Black DR. Healthy body weights: an alternative perspective. Am J Clin Nutr. 1996;63:448S-451S. https://doi.org/10.1093/ajcn/63.3.448.

PubMed  Google Scholar 

Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front Endocrinol. 2016;7:30. https://doi.org/10.3389/fendo.2016.00030.

Google Scholar 

Fuster JJ, Ouchi N, Gokce N, Walsh K. Obesity-induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease. Circ Res. 2016;118:1786–807. https://doi.org/10.1161/CIRCRESAHA.115.306885.

PubMed  PubMed Central  Google Scholar 

Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006;83:461S-465S. https://doi.org/10.1093/ajcn/83.2.461S.

PubMed  Google Scholar 

Haczeyni F, Bell-Anderson KS, Farrell GC. Causes and mechanisms of adipocyte enlargement and adipose expansion. Obes Rev Off J Int Assoc Study Obes. 2018;19:406–20. https://doi.org/10.1111/obr.12646.

Google Scholar 

Clemente-Suárez VJ, Redondo-Flórez L, Beltrán-Velasco AI, Martín-Rodríguez A, Martínez-Guardado I, Navarro-Jiménez E, et al. The Role of Adipokines in Health and Disease. Biomedicines. 2023;11:1290. https://doi.org/10.3390/biomedicines11051290.

PubMed  PubMed Central  Google Scholar 

Ahima RS, Flier JS. Adipose Tissue as an Endocrine Organ. Trends Endocrinol Metab. 2000;11:327–32. https://doi.org/10.1016/S1043-2760(00)00301-5.

PubMed  Google Scholar 

Kershaw EE, Flier JS. Adipose Tissue as an Endocrine Organ. J Clin Endocrinol Metab. 2004;89:2548–56.