Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS (2023) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2016–2020. Neuro Oncol 25:iv1–iv99. https://doi.org/10.1093/neuonc/noad149

Article  PubMed  Google Scholar 

National Comprehensive Cancer Network. NCCN Guidelines: Central Nervous System Cancers 2024. https://www.nccn.org/guidelines/guidelines-detail?category51&id51425

Sherriff J, Tamangani J, Senthil L, Cruickshank G, Spooner D, Jones B, Brookes C, Sanghera P (2013) Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide. Br J Radiol. https://doi.org/10.1259/bjr.20120414

Article  PubMed  PubMed Central  Google Scholar 

Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys 5:1725–1731. https://doi.org/10.1016/0360-3016(79)90553-4

Article  CAS  PubMed  Google Scholar 

Ali AN, Zhang P, Yung WKA, Chen Y, Movsas B, Urtasun RC, Jones CU, Choi KN, Michalski JM, Fischbach AJ, Markoe AM, Schultz CJ, Penas-Prado M, Garg MK, Hartford AC, Kim HE, Won M, Curran WJ (2018) NRG oncology RTOG 9006: a phase III randomized trial of hyperfractionated radiotherapy (RT) and BCNU versus standard RT and BCNU for malignant glioma patients. J Neurooncol 137:39–47. https://doi.org/10.1007/s11060-017-2558-x

Article  PubMed  PubMed Central  Google Scholar 

Souhami L, Seiferheld W, Brachman D, Podgorsak EB, Werner-Wasik M, Lustig R, Schultz CJ, Sause W, Okunieff P, Buckner J, Zamorano L, Mehta MP, Curran WJ (2004) Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: Report of Radiation Therapy Oncology Group 93–05 protocol. Int J Radiat Oncol Biol Phys 60:853–860. https://doi.org/10.1016/j.ijrobp.2004.04.011

Article  PubMed  Google Scholar 

Laperriere NJ, Leung PMK, McKenzie S, Milosevic M, Wong S, Glen J, Pintilie M, Bernstein M (1998) Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma. Int J Radiat Oncol Biol Phys 41:1005–1011. https://doi.org/10.1016/s0360-3016(98)00159-x

Article  CAS  PubMed  Google Scholar 

Gondi V, Pugh S, Tsien C, Chenevert T, Gilbert M, Omuro A, McDonough J, Aldape K, Srinivasan A, Rogers CL, Shi W, Suh JH, Algan O, Nedzi LA, Chan MD, Bahary JP, Mehta MP (2020) Radiotherapy (RT) Dose-intensification (DI) Using Intensity-modulated RT (IMRT) versus Standard-dose (SD) RT with Temozolomide (TMZ) in Newly Diagnosed Glioblastoma (GBM): Preliminary Results of NRG Oncology BN001. Int J Radiat Oncol Biol Phys 108:S22–S23. https://doi.org/10.1016/j.ijrobp.2020.07.2109

Article  Google Scholar 

Niyazi M, Andratschke N, Bendszus M, Chalmers AJ, Erridge SC, Galldiks N, Lagerwaard FJ, Navarria P, Af Rosenschöld PM, Ricardi U, van den Bent MJ, Weller M, Belka C, Minniti G (2023) ESTRO-EANO guideline on target delineation and radiotherapy details for glioblastoma. Radiother Oncol. https://doi.org/10.1016/j.radonc.2023.109663

Article  PubMed  Google Scholar 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996. https://doi.org/10.1056/NEJMoa043330

Article  CAS  PubMed  Google Scholar 

Roa W, Brasher PMA, Bauman G, Anthes M, Bruera E, Chan A, Fisher B, Fulton D, Gulavita S, Hao C, Husain S, Murtha A, Petruk K, Stewart D, Tai P, Urtasun R, Cairncross JG, Forsyth P (2004) Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol 22:1583–1588. https://doi.org/10.1200/jco.2004.06.082

Article  CAS  PubMed  Google Scholar 

Minniti G, De Sanctis V, Muni R, Rasio D, Lanzetta G, Bozzao A, Osti MF, Salvati M, Valeriani M, Cantore GP, Maurizi Enrici R (2009) Hypofractionated radiotherapy followed by adjuvant chemotherapy with temozolomide in elderly patients with glioblastoma. J Neurooncol 91:95–100. https://doi.org/10.1007/s11060-008-9689-z

Article  CAS  PubMed  Google Scholar 

Minniti G, Clarke E, Lanzetta G, Osti MF, Trasimeni G, Bozzao A, Romano A, Enrici RM (2011) Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis. Radiat Oncol. https://doi.org/10.1186/1748-717x-6-48

Article  PubMed  PubMed Central  Google Scholar 

Malmström A, Grønberg BH, Marosi C, Stupp R, Frappaz D, Schultz H, Abacioglu U, Tavelin B, Lhermitte B, Hegi ME, Rosell J, Henriksson R (2012) Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol 13:916–926. https://doi.org/10.1016/s1470-2045(12)70265-6

Article  PubMed  Google Scholar 

Roa W, Kepka L, Kumar N, Sinaika V, Matiello J, Lomidze D, Hentati D, Guedes de Castro D, Dyttus-Cebulok K, Drodge S, Ghosh S, Jeremić B, Rosenblatt E, Fidarova E (2015) International atomic energy agency randomized phase III study of radiation therapy in elderly and/or frail patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 33:4145–4150. https://doi.org/10.1200/jco.2015.62.6606

Article  PubMed  Google Scholar 

Perry JR, Laperriere N, O’Callaghan CJ, Brandes AA, Menten J, Phillips C, Fay M, Nishikawa R, Cairncross JG, Roa W, Osoba D, Rossiter JP, Sahgal A, Hirte H, Laigle-Donadey F, Franceschi E, Chinot O, Golfinopoulos V, Fariselli L, Wick A, Feuvret L, Back M, Tills M, Winch C, Baumert BG, Wick W, Ding K, Mason WP (2017) Short-course radiation plus temozolomide in elderly patients with glioblastoma. N Engl J Med 376:1027–1037. https://doi.org/10.1056/NEJMoa1611977

Article  CAS  PubMed  Google Scholar 

Perlow HK, Prasad RN, Yang M, Klamer B, Matsui J, Marrazzo L, Detti B, Scorsetti M, Clerici E, Arnett A, Beyer S, Ammirati M, Chakravarti A, Raval RR, Brown PD, Navarria P, Scoccianti S, Grecula JC, Palmer JD (2022) Accelerated hypofractionated radiation for elderly or frail patients with a newly diagnosed glioblastoma: a pooled analysis of patient-level data from 4 prospective trials. Cancer 128:2367–2374. https://doi.org/10.1002/cncr.34192

Article  PubMed  Google Scholar 

Gately L, Mesía C, Sepúlveda JM, del Barco S, Pineda E, Gironés R, Fuster J, Dumas M, Gill S, Navarro LM, Herrero A, Dowling A, de las Peñas R, Vaz MA, Alonso M, Lwin Z, Harrup R, Peralta S, Long A, Perez-Segura P, Ahern E, Garate CO, Wong M, Campbell R, Cuff K, Jennens R, Gallego O, Underhill C, Martinez-Garcia M, Covela M, Cooper A, Brown S, Rosenthal M, Torres J, Collins IM, Gibbs P, Balana C (2024) Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM). J Neurooncol 168:299–306. https://doi.org/10.1007/s11060-024-04668-5

Article  CAS  PubMed  Google Scholar 

Lorimer CF, Walsh G, MacKinnon M, Corbett A, Bedborough K, Greenwood K, Saran F, Chalmers AJ, Brock J (2019) Geriatric assessment of glioblastoma patients is feasible and may provide useful prognostic information. Neurooncol Pract. https://doi.org/10.1093/nop/npz040

Article  PubMed  PubMed Central  Google Scholar 

Lee HI, Kim J, Kim IA, Lee JH, Cho JH, Yoon HI, Wee CW (2023) Choosing wisely between radiotherapy dose-fractionation schedules: the molecular graded prognostic assessment (molGPA) for elderly glioblastoma (eGBM-molGPA). Int J Radiat Oncol Biol Phys 117:e125–e126. https://doi.org/10.1016/j.ijrobp.2023.06.919

Article  Google Scholar 

Kotecha R, Odia Y, Khosla AA, Ahluwalia MS (2023) Key clinical principles in the management of glioblastoma. JCO Oncol Pract 19:180–189. https://doi.org/10.1200/op.22.00476

Article  PubMed  Google Scholar 

Kruser TJ, Bosch WR, Badiyan SN, Bovi JA, Ghia AJ, Kim MM, Solanki AA, Sachdev S, Tsien C, Wang TJC, Mehta MP, McMullen KP (2019) NRG brain tumor specialists consensus guidelines for glioblastoma contouring. J Neurooncol 143:157–166. https://doi.org/10.1007/s11060-019-03152-9

Article  PubMed  PubMed Central  Google Scholar 

Karschnia P, Young JS, Dono A, Häni L, Sciortino T, Bruno F, Juenger ST, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Weller M, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, Rudà R, Bello L, Schnell O, Esquenazi Y, Ruge MI, Grau SJ, Berger MS, Chang SM, van den Bent M, Tonn J-C (2023) Prognostic validation of a new classification system for extent of resection in glioblastoma: a report of the RANO resect group. Neuro Oncol 25:940–954. https://doi.org/10.1093/neuonc/noac193

Article  CAS  PubMed  Google Scholar 

Kapoor R, Khosla D, Yadav BS, Madan R, Oinam AS, Miriyala R, Tripathi M, Khandelwal N, Mukherjee A, Sharma SC, Kumar R, Kumar N (2020) Impact of volume of irradiation on survival and quality of life in glioblastoma: a prospective, phase 2, randomized comparison of RTOG and MDACC protocols. Neurooncol Pract 7:86–93. https://doi.org/10.1093/nop/npz024

Article  PubMed  Google Scholar 

Azoulay M, Chang SD, Gibbs IC, Hancock SL, Pollom EL, Harsh GR, Adler JR, Harraher C, Li G, Hayden Gephart M, Nagpal S, Thomas RP, Recht LD, Jacobs LR, Modlin LA, Wynne J, Seiger K, Fujimoto D, Usoz M, von Eyben R, Choi CYH, Soltys SG (2020) A phase I/II trial of 5-fraction stereotactic radiosurgery with 5-mm margins with concurrent temozolomide in newly diagnosed glioblastoma: primary outcomes. Neuro Oncol 22:1182–1189.