Autophagy in benign prostatic hyperplasia: insights and therapeutic potential

Wein AJ, Partin AW, Peters CA, editors. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia: Elsevier; 2020.

Google Scholar 

Gu FL, Xia TL, Kong XT. Preliminary study of the frequency of benign prostatic hyperplasia and prostatic cancer in China. Urology. 1994;44:688–91.

Article  CAS  PubMed  Google Scholar 

Awedew AF, Han H, Abbasi B, Abbasi-Kangevari M, Ahmed MB, Almidani O, et al. The global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: a systematic analysis for the global burden of Disease Study 2019. Lancet Healthy Longev. 2022;3:e754–76.

Article  Google Scholar 

Chang WH, Tsai YS, Wang JY, Chen HL, Yang WH, Lee CC. Sex hormones and oxidative stress mediated phthalate-induced effects in prostatic enlargement. Environ Int. 2019;126:184–92.

Article  CAS  PubMed  Google Scholar 

Kristal AR, Schenk JM, Song Y, Arnold KB, Neuhouser ML, Goodman PJ, et al. Serum steroid and sex hormone-binding globulin concentrations and the risk of incident benign prostatic hyperplasia: results from the prostate cancer prevention trial. Am J Epidemiol. 2008;168:1416–24.

Article  PubMed  PubMed Central  Google Scholar 

Fiard G, Stavrinides V, Chambers ES, Heavey S, Freeman A, Ball R, et al. Cellular senescence as a possible link between prostate diseases of the ageing male. Nat Rev Urol. 2021;18:597–610.

Article  PubMed  Google Scholar 

Vickman RE, Aaron-Brooks L, Zhang R, Lanman NA, Lapin B, Gil V, et al. TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease. Nat Commun. 2022;13:2133.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasan KMM, Haque MA. Autophagy and its lineage-specific roles in the hematopoietic system. Oxid Med Cell Longev. 2023;2023:8257217.

Article  PubMed  PubMed Central  Google Scholar 

Jiang CY, Yang BY, Zhao S, Shao SH, Bei XY, Shi F, et al. Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression. Cell Death Dis. 2018;9:431.

Article  PubMed  PubMed Central  Google Scholar 

Saito M, Tsounapi P, Oikawa R, Shimizu S, Honda M, Sejima T, et al. Prostatic ischemia induces ventral prostatic hyperplasia in the SHR; possible mechanism of development of BPH. Sci Rep. 2014;4:3822.

Article  PubMed  PubMed Central  Google Scholar 

Oh SH, Lee DW, Choi YB, Lee YH, Ju JS. Measurement of autophagy flux in benign prostatic hyperplasia in vitro. Prostate Int. 2020;8:70–7.

Article  PubMed  PubMed Central  Google Scholar 

Zachari M, Ganley IG. The mammalian ULK1 complex and autophagy initiation. Essays Biochem. 2017;61:585–96.

Article  PubMed  PubMed Central  Google Scholar 

Alers S, Löffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol. 2012;32:2–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev. 2010;90:1383–435.

Article  CAS  PubMed  Google Scholar 

Kma L, Baruah TJ. The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. Biotechnol Appl Biochem. 2022;69:248–64.

Article  CAS  PubMed  Google Scholar 

Gallagher LE, Chan EYW. Early signalling events of autophagy. Essays Biochem. 2013;55:1–15.

Article  PubMed  Google Scholar 

Boya P, Reggiori F, Codogno P. Emerging regulation and functions of autophagy. Nat Cell Biol. 2013;15:713–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bento CF, Renna M, Ghislat G, Puri C, Ashkenazi A, Vicinanza M, et al. Mammalian autophagy: how does it work? Annu Rev Biochem. 2016;85:685–713.

Article  CAS  PubMed  Google Scholar 

Sun WL. Ambra1 in autophagy and apoptosis: implications for cell survival and chemotherapy resistance. Oncol Lett. 2016;12:367–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lystad AH, Carlsson SR, Simonsen A. Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes. Autophagy. 2019;15:1485–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye Y, Tyndall ER, Bui V, Bewley MC, Wang G, Hong X, et al. Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy. Nat Commun. 2023;14:5503.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Long YC, Shen HM. Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy. Autophagy. 2015;11:1711–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu RF, Fu G, Li J, Yang YF, Wang XG, Bai PD, et al. Roles of autophagy in androgen-induced benign prostatic hyperplasia in castrated rats. Exp Ther Med. 2018;15:2703–10.

CAS  PubMed  PubMed Central  Google Scholar 

Azzouni F, Mohler J. Role of 5α-reductase inhibitors in benign prostatic diseases. Prostate Cancer Prostatic Dis. 2012;15:222–30.

Article  CAS  PubMed  Google Scholar 

Roehrborn CG, Siami P, Barkin J, Damião R, Major-Walker K, Nandy I, et al. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol. 2010;57:123–31.

Article  CAS  PubMed  Google Scholar 

McConnell JD, Bruskewitz R, Walsh P, Andriole G, Lieber M, Holtgrewe HL, et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group. N Engl J Med. 1998;338:557–63.

Article  CAS  PubMed  Google Scholar 

Liu C, Xu P, Chen D, Fan X, Xu Y, Li M, et al. Roles of autophagy-related genes Beclin-1 and LC3 in the development and progression of prostate cancer and benign prostatic hyperplasia. Biomedical Rep. 2013;1:855–60.

Article  CAS  Google Scholar 

Yang BY, Jiang CY, Dai CY, Zhao RZ, Wang XJ, Zhu YP, et al. 5-ARI induces autophagy of prostate epithelial cells through suppressing IGF-1 expression in prostate fibroblasts. Cell Prolif. 2019;52:e12590.

Article  PubMed  PubMed Central  Google Scholar 

Jung S, Jeong H, Yu S-W. Autophagy as a decisive process for cell death. Exp Mol Med. 2020;52:921–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Yang X, Wang H, Xu E, Xi Z. Inhibition of androgen induces autophagy in benign prostate epithelial cells. Int J Urology: Official J Japanese Urol Association. 2014;21:195–9.

Article  CAS  Google Scholar 

Quiles MT, Arbós MA, Fraga A, de Torres IM, Reventós J, Morote J. Antiproliferative and apoptotic effects of the herbal agent Pygeum Africanum on cultured prostate stromal cells from patients with benign prostatic hyperplasia (BPH). Prostate. 2010;70:1044–53.

Article  CAS 

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