Ostrom QT, Price M, Neff C et al (2023) CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2016–2020. Neurooncology 25(Supplement4):iv1–iv99. https://doi.org/10.1093/neuonc/noad149

Article  Google Scholar 

Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the Central Nervous System: a summary. Neuro Oncol Aug 2(8):1231–1251. https://doi.org/10.1093/neuonc/noab106

Article  CAS  Google Scholar 

Choudhury A, Magill ST, Eaton CD et al (2022) Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet May 54(5):649–659. https://doi.org/10.1038/s41588-022-01061-8

Article  CAS  Google Scholar 

Choudhury A, Chen WC, Lucas CG et al (2023) Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Neuro Oncol Mar 14(3):520–530. https://doi.org/10.1093/neuonc/noac224

Article  CAS  Google Scholar 

Youngblood MW, Miyagishima DF, Jin L et al (2021) Associations of meningioma molecular subgroup and tumor recurrence. Neuro Oncol May 5(5):783–794. https://doi.org/10.1093/neuonc/noaa226

Article  CAS  Google Scholar 

Youngblood MW, Erson-Omay Z, Li C et al (2023) Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas. Nat Commun Oct 7(1):6279. https://doi.org/10.1038/s41467-023-41926-y

Article  CAS  Google Scholar 

Clark VE, Erson-Omay EZ, Serin A et al (2013) Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Sci Mar 1(6123):1077–1080. https://doi.org/10.1126/science.1233009

Article  CAS  Google Scholar 

Clark VE, Harmancı AS, Bai H et al (2016) Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nat Genet Oct 48(10):1253–1259. https://doi.org/10.1038/ng.3651

Article  CAS  Google Scholar 

Hua L, Alkhatib M, Podlesek D et al Two predominant molecular subtypes of spinal meningioma: thoracic NF2-mutant tumors strongly associated with female sex, and cervical AKT1-mutant tumors originating ventral to the spinal cord. Acta Neuropathol. 2022/11/01 2022;144(5):1053–1055. https://doi.org/10.1007/s00401-022-02474-9

Ricklefs FL, Fita KD, Mohme M et al (2022) Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas. Acta Neuropathol 144(5):1057–1059. https://doi.org/10.1007/s00401-022-02504-6. /11/01 2022

Article  PubMed  PubMed Central  Google Scholar 

Goldbrunner R, Stavrinou P, Jenkinson MD et al (2021) EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol Nov 2(11):1821–1834. https://doi.org/10.1093/neuonc/noab150

Article  CAS  Google Scholar 

Zhou W, Triche TJ Jr., Laird PW, Shen H (2018) SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions. Nucleic Acids Res Nov 16(20):e123. https://doi.org/10.1093/nar/gky691

Article  CAS  Google Scholar 

Ricklefs FL, Fita KD, Mohme M et al (2022) Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas. Acta Neuropathol Nov 144(5):1057–1059. https://doi.org/10.1007/s00401-022-02504-6

Article  Google Scholar 

Wilkerson MD, Hayes DN (2010) ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Bioinf Jun 15(12):1572–1573. https://doi.org/10.1093/bioinformatics/btq170

Article  CAS  Google Scholar 

Du P, Zhang X, Huang CC et al (2010) Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinf Nov 30:11:587. https://doi.org/10.1186/1471-2105-11-587

Article  CAS  Google Scholar 

Harmancı AS, Youngblood MW, Clark VE et al (2017) Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nat Commun Feb 14:8:14433. https://doi.org/10.1038/ncomms14433

Article  CAS  Google Scholar 

Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol Dec 5(12):1045–1054. https://doi.org/10.1016/s1474-4422(06)70625-1

Article  CAS  Google Scholar 

Gottfried ON, Gluf W, Quinones-Hinojosa A, Kan P, Schmidt MH (2003) Spinal meningiomas: surgical management and outcome. Neurosurg Focus Jun 15(6):e2. https://doi.org/10.3171/foc.2003.14.6.2

Article  Google Scholar 

Kobayashi K, Ando K, Matsumoto T et al (2021) Clinical features and prognostic factors in spinal meningioma surgery from a multicenter study. Sci Rep 11(1):11630. https://doi.org/10.1038/s41598-021-91225-z. /06/02 2021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Setzer M, Vatter H, Marquardt G, Seifert V, Vrionis FD (2007) Oct. Management of spinal meningiomas: surgical results and a review of the literature. Neurosurgical Focus FOC. 01 2007;23(4):E14. https://doi.org/10.3171/FOC-07/10/E14

Moreau JT, Hankinson TC, Baillet S, Dudley RWR (2020) Individual-patient prediction of meningioma malignancy and survival using the Surveillance, Epidemiology, and end results database. Npj Digit Med 2020/01/30 3(1):12. https://doi.org/10.1038/s41746-020-0219-5

Article  Google Scholar 

Westwick HJ, Shamji MF (2015) Sep. Effects of sex on the incidence and prognosis of spinal meningiomas: a Surveillance, Epidemiology, and End Results study. Journal of Neurosurgery: Spine SPI. 01 2015;23(3):368–373. https://doi.org/10.3171/2014.12.SPINE14974

Blitshteyn S, Crook JE, Jaeckle KA (2008) Is there an association between meningioma and hormone replacement therapy? J Clin Oncol Jan 10(2):279–282. https://doi.org/10.1200/jco.2007.14.2133

Article  Google Scholar 

DeGrood RM, Beemer WH, Fenner DE, Compton AA (1987) A large meningioma presenting as a neurologic emergency in late pregnancy. Obstet Gynecol Mar 69(3 Pt 2):439–440

CAS  Google Scholar 

Khazanchi R, Nandoliya KR, Shahin MN et al (2024) Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort. J Neurosurg Jan 19:1–10. https://doi.org/10.3171/2023.11.Jns23732

Article  Google Scholar 

Li Q, Coulson H, Klaassen Z et al (2013) Emerging association between androgen deprivation therapy and male meningioma: significant expression of luteinizing hormone-releasing hormone receptor in male meningioma. Prostate Cancer Prostatic Dis Dec 16(4):387–390. https://doi.org/10.1038/pcan.2013.45

Article  CAS  Google Scholar 

SAITOH Y, OKU Y, Go IZUMOTOS (1989) Rapid Growth of a Meningioma during pregnancy: relationship with estrogen and progesterone receptors—Case Report—. Neurologia medico-chirurgica 29(5):440–443

Article  CAS  PubMed  Google Scholar 

Huang H, Buhl R, Hugo HH, Mehdorn HM (2005) Clinical and histological features of multiple meningiomas compared with solitary meningiomas. Neurol Res Apr 27(3):324–332. https://doi.org/10.1179/016164105x39932

Article  Google Scholar 

Vasudevan HN, Braunstein SE, Phillips JJ et al (2018) Comprehensive Molecular Profiling identifies FOXM1 as a key transcription factor for Meningioma Proliferation. Cell Rep Mar 27(13):3672–3683. https://doi.org/10.1016/j.celrep.2018.03.013

Article  CAS  Google Scholar 

Kishida Y, Natsume A, Kondo Y et al (2011) Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses. Carcinogenesis 33(2):436–441. https://doi.org/10.1093/carcin/bgr260

Article  CAS  PubMed  Google Scholar 

Mahara S, Lee PL, Feng M, Tergaonkar V, Chng WJ, Yu Q (2016) HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc Natl Acad Sci U S Jun 28 113(26):E3735–E3744. https://doi.org/10.1073/pnas.1602079113

Article  CAS  Google Scholar 

Kong KA, Lee JY, Oh JH, Lee Y, Kim MH (2014) Akt1 mediates the posterior hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts. Biochim Biophys Acta Sep 1839(9):793–799. https://doi.org/10.1016/j.bbagrm.2014.06.011

Article  CAS  Google Scholar 

Kong KA, Yoon H, Kim MH (2013) Akt1 as a putative regulator of hox genes. Gene Jan 25(2):287–291. https://doi.org/10.1016/j.gene.2012.10.034

Article  CAS  Google Scholar 

Shah N, Sukumar S (2010) The hox genes and their roles in oncogenesis. Nat Rev Cancer 10(5):361–371. https://doi.org/10.1038/nrc2826. /05/01 2010

Article  CAS  PubMed  Google Scholar 

Collord G, Tarpey P, Kurbatova N et al An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures. Sci Rep. 2018/09/10 2018;8(1):13537. https://doi.org/10.1038/s41598-018-31659-0

Paramasivam N, Hübschmann D, Toprak UH et al (2019) Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. Acta Neuropathol 138(2):295–308. https://doi.org/10.1007/s00401-019-02008-w. 08/01 2019