Author byline as per print journal: Professor Irene Krämer, PhD; Frank Erdnuess, PhD; Judith Thiesen, PhD, Germany

Abstracts:
This study assessed the physicochemical stability of Bortezomib Accord 2.5 mg/mL solutions for subcutaneous and intravenous injection under various storage conditions. Bortezomib 2.5 mg/mL solutions for subcutaneous injection remained stable for up to 84 days in punctured vials and polypropylene syringes under light-protected conditions at room temperature, with negligible changes in pH, colour, or particulate matter. Diluted 1 mg/mL solutions retained stability for 72 hours (room temperature, exposed to light), 42 days (room temperature, protected from light), and 84 days (refrigerated, protected from light). These findings provide valuable insights for clinical practice and medication management protocols.

Submitted: 4 March 2024; Revised: 15 April 2024; Accepted: 26 April 2024; Published online first: 6 May 2024

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This manuscript has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.