Anti-synthetase and myelodysplastic syndromes with deep morphea: an example of shared immunopathogenesis? A case-based review

Hum RM, Lilleker JB, Lamb JA, Oldroyd AGS, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, Danieli MG, Oakley P, Griger Z, Nguyen Thi Phuong T, Kodishala C, Vazquez-Del Mercado M, Andersson H, De Paepe B, De Bleecker JL, Maurer B, McCann L, Pipitone N, McHugh N, New RP, Ollier WE, Krogh NS, Vencovsky J, Lundberg IE, Chinoy H (2024) MYONET Registry. Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis: results from the MYONET registry. Rheumatology (Oxford). ;63(8):2093–2100. https://doi.org/10.1093/rheumatology/kead481. Erratum in: Rheumatology (Oxford). 2024;63(8):2316. doi: 10.1093/rheumatology/keae186

Giannouli S, Voulgarelis M (2014) A comprehensive review of myelodysplastic syndrome patients with autoimmune diseases. Expert Rev Clin Immunol 10(12):1679–1688. https://doi.org/10.1586/1744666X.2014.970181

Article  PubMed  Google Scholar 

Cristiano A, Belardi R, Hajrullaj H, Fabiani E, Falconi G, Galossi E, Bernardini S, Voso MT, Nuccetelli M (2023) Correlation analysis between auto-immunological and mutational profiles in myelodysplastic syndromes. Inflamm Res 72(8):1695–1707. https://doi.org/10.1007/s00011-023-01773-5

Article  PubMed  PubMed Central  Google Scholar 

Pauling JD, Christopher-Stine L (2021) The etiopathogenic significance, clinical relevance and therapeutic implications of vasculopathy in idiopathic inflammatory myopathy. Rheumatology (Oxford). ;60(4):1593–1607. https://doi.org/10.1093/rheumatology/keaa816. Erratum in: Rheumatology (Oxford). 2021;60(8):3960. doi: 10.1093/rheumatology/keab431

Torres RJ, Pinal FI, Selva OA, Campbell B, Muñoz BS, Mejía DN, Núñez AC, Milisenda J, Casal DM, Pak K, Guillén DA, Trallero AE, Gil VA, Mammen AL (2024) Nailfold capillaroscopy findings of a multicentric multi-ethnic cohort of patients with idiopathic inflammatory myopathies. Clin Exp Rheumatol 42(2):367–376. https://doi.org/10.55563/clinexprheumatol/l9gudh

Article  Google Scholar 

Lambova SN (2024) The value of Nailfold Capillaroscopy in the classification and Differential diagnosis of Raynaud’s Phenomenon in Rheumatology. Curr Rheumatol Rev 20(2):108–114. https://doi.org/10.2174/1573397119666230905151903

Article  PubMed  Google Scholar 

Marie I, Josse S, Decaux O, Diot E, Landron C, Roblot P, Jouneau S, Hatron PY, Hachulla E, Vittecoq O, Menard JF, Jouen F, Dominique S (2013) Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome. Eur J Intern Med 24(5):474–479. https://doi.org/10.1016/j.ejim.2013.01.002

Article  PubMed  Google Scholar 

Galindo-Feria AS, Notarnicola A, Lundberg IE, Horuluoglu B (2022) Aminoacyl-tRNA synthetases: on anti-synthetase syndrome and Beyond. Front Immunol 13:866087. https://doi.org/10.3389/fimmu.2022.866087

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto S, Yoshida A, Okazaki Y, Gono T, Kuwana M (2024) Clinical phenotyping in patients with anti-synthetase antibodies using cluster analysis. Rheumatol Adv Pract 8(2):rkae049. https://doi.org/10.1093/rap/rkae049

Article  PubMed  PubMed Central  Google Scholar 

Sparsa A, Liozon E, Herrmann F, Ly K, Lebrun V, Soria P, Loustaud-Ratti V, Bouyssou-Gauthier ML, Boulinguez S, Bédane C, Jauberteau MO, Vidal E, Bonnetblanc JM (2002) Routine vs extensive malignancy search for adult dermatomyositis and polymyositis: a study of 40 patients. Arch Dermatol 138(7):885–890. https://doi.org/10.1001/archderm.138.7.885

Article  PubMed  Google Scholar 

Rana J, Moy AP, Piris A, Smith GP (2017) Lupus and scleroderma overlap features in a 28-year-old man with anti-PL-12 anti-synthetase syndrome. Dermatol Online J 23(9). https://doi.org/10.5070/d3239036485

Ebbo M, Chagnaud C, Figarella-Branger D, Legall S, Harle JR, Schleinitz N (2013) Antisynthethase syndrome presenting as peripheral limb fasciitis. Joint Bone Spine 80(5):528–530. https://doi.org/10.1016/j.jbspin.2013.02.013

Article  PubMed  Google Scholar 

Abel A, Lazaro E, Ralazamahaleo M, Pierrisnard E, Suzon B, Bonnet F, Mercié P, Macey J, Agossou M, Viallard JF, Deligny C, Rivière E (2023) Phenotypic profiles among 72 caucasian and afro-caribbean patients with antisynthetase syndrome involving Anti-PL7 or Anti-PL12 autoantibodies. Eur J Intern Med 115:104–113. https://doi.org/10.1016/j.ejim.2023.06.012

Article  PubMed  Google Scholar 

Papara C, De Luca DA, Bieber K, Vorobyev A, Ludwig RJ, Morphea (2023) The 2023 update. Front Med (Lausanne) 10:1108623. https://doi.org/10.3389/fmed.2023.1108623

Article  PubMed  Google Scholar 

Voermans NC, Pillen S, de Jong EM, Creemers MC, Lammens M, van Alfen N (2008) Morphea profunda presenting as a neuromuscular mimic. J Clin Neuromuscul Dis 9(4):407–414. https://doi.org/10.1097/CND.0b013e318175c495

Article  PubMed  Google Scholar 

Chen HW, Walker AM, Stein AB, Chen SL, Schollaert-Fitch KL, Torok KS, Jacobe HT (2023) Clinical characteristics Associated with Musculoskeletal Extracutaneous manifestations in Pediatric and Adult Morphea: a prospective, Cohort Study. J Invest Dermatol 143(10):1955–1963e3. https://doi.org/10.1016/j.jid.2023.04.010

Article  PubMed  Google Scholar 

Deng Z, Fan T, Xiao C, Tian H, Zheng Y, Li C, He J (2024) TGF-β signaling in health, disease, and therapeutics. Signal Transduct Target Ther 9(1):61. https://doi.org/10.1038/s41392-024-01764-w

Article  PubMed  PubMed Central  Google Scholar 

Swinkels M, Rijkers M, Voorberg J, Vidarsson G, Leebeek FWG, Jansen AJG (2018) Emerging concepts in Immune Thrombocytopenia. Front Immunol 9:880. https://doi.org/10.3389/fimmu.2018.00880

Article  PubMed  PubMed Central  Google Scholar 

Komura K, Yanaba K, Bouaziz JD, Yoshizaki A, Hasegawa M, Varga J, Takehara K, Matsushita T (2024) Perspective to precision medicine in scleroderma. Front Immunol 14:1298665. https://doi.org/10.3389/fimmu.2023.1298665

Article  PubMed  PubMed Central  Google Scholar 

Khatri S, Torok KS, Mirizio E, Liu C, Astakhova K (2019) Autoantibodies in Morphea: an update. Front Immunol 10:1487. https://doi.org/10.3389/fimmu.2019.01487

Article  PubMed  PubMed Central  Google Scholar 

Leitenberger JJ, Cayce RL, Haley RW, Adams-Huet B, Bergstresser PR, Jacobe HT (2009) Distinct autoimmune syndromes in morphea: a review of 245 adult and pediatric cases. Arch Dermatol 145(5):545–550. https://doi.org/10.1001/archdermatol.2009.79

Article  PubMed  PubMed Central  Google Scholar 

Kaur M, Sadhukhan S, Bhardwaj A, Patra S, Rao M, Alam A (2023) Linear morphea with overlying lichen sclerosus and calcinosis cutis associated with juvenile dermatomyositis. Pediatr Dermatol 40(3):500–502. https://doi.org/10.1111/pde.15178

Article  PubMed  Google Scholar 

Jibbe A, Neill BC, Tolkachjov SN (2021) Concurrent Dermatomyositis, Celiac Disease, and Dermatitis Herpetiformis in a patient with a history of Morphea. Kans J Med 14:203–205. https://doi.org/10.17161/kjm.vol1415224

Article  PubMed  PubMed Central  Google Scholar 

Hochman MJ, DeZern AE (2022) Myelodysplastic syndrome and autoimmune disorders: two sides of the same coin? Lancet Haematol 9(7):e523–e34. https://doi.org/10.1016/S2352-3026(22)00138-7

Article  PubMed  Google Scholar 

Wang C, Yang Y, Gao S, Chen J, Yu J, Zhang H et al (2018) Immune dysregulation in myelodysplastic syndrome: clinical features, pathogenesis and therapeutic strategies. Crit Rev Oncol Hematol 122:123–132. https://doi.org/10.1016/j.critrevonc.2017.12.013

Article  PubMed  Google Scholar 

Urrechaga E (2024) Screening of myelodysplastic syndromes using Research parameters of Complete Blood Count: automated detection of Dysplasia. Clin Lab Med 44(3):387–396. https://doi.org/10.1016/j.cll.2024.05.001

Article  PubMed  Google Scholar 

McNallan KT, Aponte C, el-Azhary R et al (2007) Immunophenotyping of chimeric cells in localized scleroderma. Rheumatology (Oxford) 46(3):398–402. https://doi.org/10.1093/rheumatology/kel297

Article  PubMed  Google Scholar 

Sadigh S, Kim AS (2024) Molecular Pathology of Myeloid neoplasms: Molecular Pattern Recognition. Clin Lab Med 44(2):339–353. https://doi.org/10.1016/j.cll.2023.08.007

Article  PubMed  Google Scholar 

Voulgarelis M, Giannouli S, Ritis K, Tzioufas AG (2004) Myelodysplasia-associated autoimmunity: clinical and pathophysiologic concepts. Eur J Clin Invest 34(10):690–700. https://doi.org/10.1111/j.1365-2362.2004.01417.x

Article  PubMed  Google Scholar 

Liang Q, Zhao J, Zhang L, Gao Z, Pan H, Fang L, Shi J (2022) Association of systemic inflammatory and autoimmune manifestations with myelodysplastic syndromes: a systematic review and meta-analysis. Med (Baltim) 101(46):e31427. https://doi.org/10.1097/MD.0000000000031427

Article  Google Scholar 

Fozza C (2018) The burden of autoimmunity in myelodysplastic syndromes. Hematol Oncol 36(1):15–23. https://doi.org/10.1002/hon.2423

Article  PubMed  Google Scholar 

Zhao XC, Ju B, Xiu NN, Sun XY, Meng FJ (2024) When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmu

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