Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162–73.

Article  PubMed  Google Scholar 

Tintore M, Cobo-Calvo A, Carbonell P, et al. Effect of changes in MS Diagnostic Criteria over 25 years on time to treatment and prognosis in patients with clinically isolated syndrome. Neurology. 2021;97:e1641–52.

Article  PubMed  Google Scholar 

Cobo-Calvo A, Tur C, Otero-Romero S, et al. Association of very early treatment initiation with the risk of long-term disability in patients with a first demyelinating event. Neurology. 2023;101:e1280–92.

Article  PubMed  Google Scholar 

Solomon AJ, Arrambide G, Brownlee WJ, et al. Differential diagnosis of suspected multiple sclerosis: an updated consensus approach. Lancet Neurol. 2023;22:750–68. Updated consensus recommendations for approaching differential diagnoses of MS that include neurological symptoms or signs and MRI findings that should prompt the consideration of alternative diagnoses as well as approaches to typical presentations of MS.

Article  PubMed  Google Scholar 

Calabrese M, Gasperini C, Tortorella C, et al. Better explanations in multiple sclerosis diagnostic workup. Neurology. 2019;92:e2527–37.

Article  PubMed  PubMed Central  Google Scholar 

Landes-Chateau C, Levraut M, Cohen M, Sicard M, Papeix C, Cotton F, Balcerac A, Themelin A, Mondot L, Lebrun-Frenay C. Identification of demyelinating lesions and application of McDonald criteria when confronted with white matter lesions on brain MRI. Rev Neurol (Paris). 2023;179:1103–10.

Article  PubMed  Google Scholar 

Solomon AJ, Pettigrew R, Naismith RT, Chahin S, Krieger S, Weinshenker B. Challenges in multiple sclerosis diagnosis: misunderstanding and misapplication of the McDonald criteria. Mult Scler J. 2021;27:250–8.

Article  Google Scholar 

Solomon AJ, Kaisey M, Krieger SC, Chahin S, Naismith RT, Weinstein SM, Shinohara RT, Weinshenker BG. Multiple sclerosis diagnosis: knowledge gaps and opportunities foreducational intervention in neurologists in the United States. Mult Scler. 2022;28:1248.

Article  PubMed  Google Scholar 

Solomon AJ, Klein EP, Bourdette D. Undiagnosing multiple sclerosis. Neurology. 2012;78:1986–91.

Article  PubMed  PubMed Central  Google Scholar 

Solomon AJ, Bourdette DN, Cross AH, et al. The contemporary spectrum of multiple sclerosis misdiagnosis. Neurology. 2016;87:1393–9.

Article  PubMed  PubMed Central  Google Scholar 

Schumacher GA, Beebe G, Kibler RF, Kurland LT, Kurtzke JF, McDowell F, Nagler B, Sibley WA, Tourtellotte WW, Willmon TL. Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann N Y Acad Sci. 1965;122:552–68.

Article  PubMed  Google Scholar 

Engell T. A clinico-pathoanatomical study of multiple sclerosis diagnosis. Acta Neurol Scand. 1988;78:39–44.

Article  PubMed  Google Scholar 

Herndon RM, Brooks B. Misdiagnosis of multiple sclerosis. Semin Neurol. 1985;5:94–8.

Article  Google Scholar 

Murray TJ, Murray SJ. Characteristics of patients found not to have multiple sclerosis. Can Med Assoc J. 1984;131:336.

PubMed  PubMed Central  Google Scholar 

Hankey GJ, Stewart-Wynne EG. Pseudo-multiple sclerosis: a clinico-epidemiological study. Clin Exp Neurol. 1987;24:11–9.

PubMed  Google Scholar 

Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983;13:227–31.

Article  PubMed  Google Scholar 

Poser CM. Misdiagnosis of multiple sclerosis and β-interferon. Lancet. 1997;349:1916.

Article  PubMed  Google Scholar 

Rudick RA, Schiffer RB, Schwetz KM, Herndon RM. Multiple sclerosis. The problem of incorrect diagnosis. Arch Neurol. 1986;43:578–83.

Article  PubMed  Google Scholar 

Skegg K, Corwin PA, Skegg DC. How often is multiple sclerosis mistaken for a psychiatric disorder? Psychol Med. 1988;18:733–6.

Article  PubMed  Google Scholar 

Rolak LA, Fleming JO. The differential diagnosis of multiple sclerosis. Neurologist. 2007;13:57–72.

Article  PubMed  Google Scholar 

Kaisey M, Solomon AJ, Luu M, Giesser BS, Sicotte NL. Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers. Mult Scler Relat Disord. 2019;30:51–6.

Article  PubMed  Google Scholar 

Midaglia L, Sastre-Garriga J, Pappolla A, et al. The frequency and characteristics of MS misdiagnosis in patients referred to the multiple sclerosis centre of Catalonia. Mult Scler J. 2021;27:913–21.

Article  Google Scholar 

Gaitán MI, Sanchez M, Farez MF, Fiol MP, Ysrraelit MC, Solomon AJ, Correale J. The frequency and characteristics of multiple sclerosis misdiagnosis in Latin America: a referral center study in Buenos Aires, Argentina. Mult Scler J. 2022;28:1373–81.

Article  Google Scholar 

Wang Y, Bou Rjeily N, Koshorek J, Grkovski R, Aulakh M, Lin D, Solomon AJ, Mowry EM. Clinical and radiologic characteristics associated with multiple sclerosis misdiagnosis at a tertiary referral center in the United States. Mult Scler J. 2023;29:1428–36.

Article  Google Scholar 

Abdula RH, Kurmanji MT, Mohammed ZA, Al-Bajalan SJ. Revision of multiple sclerosis cases according to new 2017 McDonald criteria among diagnosed patients in Sulaimani city. J Sulaimani Med Coll. 2021;11:323–33.

Article  Google Scholar 

Tieppo EM, de Silva S, Silva GD, da Silva TFF, et al. Misdiagnosis in multiple sclerosis in a Brazilian reference center: Clinical, radiological, laboratory profile and failures in the diagnostic process—Cohort study. Mult Scler J. 2023;29:1755–64.

Article  Google Scholar 

de Seabra MML, Abreu PMP, Mendonça MTS, Reis JJCS, Sá MJPM, Guimarães Ferreira Almeida JC. Diagnostic revisions in multiple sclerosis. Clin Exp Neuroimmunol. 2020;11:171–5.

Article  Google Scholar 

Katsarogiannis E, Landtblom AM, Kristoffersson A, Wikström J, Semnic R, Berntsson SG. Absence of Oligoclonal Bands in multiple sclerosis: a call for Differential diagnosis. J Clin Med. 2023;12:4656.

Article  PubMed  PubMed Central  Google Scholar 

Caparo-Zamalloa C, Castro-Suarez S, Cortez-Escalante J, Aguirre-Quispe W, Guevara-Silva E, Osorio-Marcatinco V, Meza-Vega M. Brainstem syndrome at onset is related to an early MS diagnosis in Peru: a national referral center cohort. Heliyon. 2021;7:e08069.

Article  PubMed  PubMed Central  Google Scholar 

Yamout BI, Khoury SJ, Ayyoubi N, Doumiati H, Fakhreddine M, Ahmed SF, Tamim H, Al-Hashel JY, Behbehani R, Alroughani R. Alternative diagnoses in patients referred to specialized centers for suspected MS. Mult Scler Relat Disord. 2017;18:85–9.

Article  PubMed  Google Scholar 

Carmosino MJ, Brousseau KM, Arciniegas DB, Carboy JR. Initial evaluations for multiple sclerosis in a university multiple sclerosis center: outcomes and role of magnetic resonance imaging in referral. Arch Neurol. 2005;62:585–90.

Article  PubMed  Google Scholar 

Wingerchuk DM, Banwell B, Bennett JL, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015;85:177–89.

Article  PubMed  PubMed Central  Google Scholar 

Banwell B, Bennett JL, Marignier R, et al. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. Lancet Neurol. 2023;22:268–82.

Article  PubMed  Google Scholar 

Pittock SJ, Lennon VA, Bakshi N, Shen L, McKeon A, Quach H, Briggs FBS, Bernstein AL, Schaefer CA, Barcellos LF. Seroprevalence of aquaporin-4-IgG in a northern California population representative cohort of multiple sclerosis. JAMA Neurol. 2014;71:1433–6.

Article  PubMed  Google Scholar 

Carnero Contentti E, López PA, Criniti J, et al. Frequency of NMOSD misdiagnosis in a cohort from Latin America: impact and evaluation of different contributors. Mult Scler J. 2023;29:277–86.

Article  Google Scholar 

Santoro JD, Gould J, Panahloo Z, Thompson E, Lefelar J, Palace J. Patient pathway to diagnosis of myelin oligodendrocyte glycoprotein antibody-Associated Disease (MOGAD): findings from a multinational survey of 204 patients. Neurol Ther. 2023;12:1081–101.

Article