The authors are grateful for support by the SGC, a registered charity (no: 1097737) that receives funds from: Bayer A.G., Boehringer Ingelheim, Canada Foundation for Innovation, Genentech, Genome Canada [OGI-196], EU/EFPIA/OICR/McGill/KTH/Diamond, Innovative Medicines Initiative 2 Joint Undertaking [EUbOPEN grant 875510], Janssen, Pfizer and Takeda as well as support received by the German translational cancer network (DKTK), the Frankfurt Cancer Institute (FCI); the German Cancer Aid (Krebshilfe) grant TACTIC and the SFB1430 (Molecular Mechanisms of Cell State Transitions).