Cieza, A. et al. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 2006–2017 (2021).
Hartvigsen, J. et al. What low back pain is and why we need to pay attention. Lancet 391, 2356–2367 (2018).
Risbud, M. V. & Shapiro, I. M. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat. Rev. Rheumatol. 10, 44–56 (2014).
Article CAS PubMed Google Scholar
Livshits, G. et al. Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study. Ann. Rheum. Dis. 70, 1740–1745 (2011).
Francisco, V. et al. A new immunometabolic perspective of intervertebral disc degeneration. Nat. Rev. Rheumatol. 18, 47–60 (2022).
Article CAS PubMed Google Scholar
Zehra, U. et al. Mechanisms and clinical implications of intervertebral disc calcification. Nat. Rev. Rheumatol. 18, 352–362 (2022).
Article PubMed PubMed Central Google Scholar
Clouet, J., Fusellier, M., Camus, A., Le Visage, C. & Guicheux, J. Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies. Adv. Drug. Deliv. Rev. 146, 306–324 (2019).
Article CAS PubMed Google Scholar
Lyu, F. J. et al. Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions. Bone Res. 9, 7 (2021).
Article CAS PubMed PubMed Central Google Scholar
Gao, B. et al. Discovery and application of postnatal nucleus pulposus progenitors essential for intervertebral disc homeostasis and degeneration. Adv. Sci. 9, e2104888 (2022).
Tu, J. et al. Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression. Adv. Sci. 9, e2103631 (2022).
Wang, H. et al. Decoding the annulus fibrosus cell atlas by scRNA-seq to develop an inducible composite hydrogel: A novel strategy for disc reconstruction. Bioact. Mater 14, 350–363 (2022).
PubMed PubMed Central Google Scholar
Gan, Y. et al. Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs. Bone Res. 9, 37 (2021).
Article CAS PubMed PubMed Central Google Scholar
Lyu, F. J. et al. IVD progenitor cells: a new horizon for understanding disc homeostasis and repair. Nat. Rev. Rheumatol. 15, 102–112 (2019).
Binch, A. L. A., Fitzgerald, J. C., Growney, E. A. & Barry, F. Cell-based strategies for IVD repair: clinical progress and translational obstacles. Nat. Rev. Rheumatol. 17, 158–175 (2021).
Kamali, A. et al. Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions. Theranostics 11, 27–47 (2021).
Article CAS PubMed PubMed Central Google Scholar
DiStefano, T. J. et al. Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations. Adv. Healthc. Mater. 11, e2100596 (2022).
Mohd Isa, I. L. et al. Intervertebral disc degeneration: biomaterials and tissue engineering strategies toward precision medicine. Adv. Healthc. Mater. 11, e2102530 (2022).
Roh, E. J. et al. Genetic therapy for intervertebral disc degeneration. Int. J. Mol. Sci. 22, 1579 (2021).
Article CAS PubMed PubMed Central Google Scholar
Fields, A. J., Ballatori, A., Liebenberg, E. C. & Lotz, J. C. Contribution of the endplates to disc degeneration. Curr. Mol. Biol. Rep. 4, 151–160 (2018).
Article PubMed PubMed Central Google Scholar
Ashinsky, B. G. et al. Intervertebral disc degeneration is associated with aberrant endplate remodeling and reduced small molecule transport. J. Bone Miner. Res. 35, 1572–1581 (2020).
Huang, Y. C., Urban, J. P. & Luk, K. D. Intervertebral disc regeneration: do nutrients lead the way? Nat. Rev. Rheumatol. 10, 561–566 (2014).
Singh, A., Gill, G., Kaur, H., Amhmed, M. & Jakhu, H. Role of osteopontin in bone remodeling and orthodontic tooth movement: a review. Prog. Orthod. 19, 18 (2018).
Article PubMed PubMed Central Google Scholar
Icer, M. A. & Gezmen-Karadag, M. The multiple functions and mechanisms of osteopontin. Clin. Biochem. 59, 17–24 (2018).
Article CAS PubMed Google Scholar
Si, J., Wang, C., Zhang, D., Wang, B. & Zhou, Y. Osteopontin in bone metabolism and bone diseases. Med. Sci. Monit. 26, e919159 (2020).
Article CAS PubMed PubMed Central Google Scholar
Lin, C. et al. Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model. Aging 14, 253–271 (2022).
Article CAS PubMed PubMed Central Google Scholar
Liu, Q. et al. Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis. Genes Dis. 9, 128–139 (2022).
Article CAS PubMed Google Scholar
Tomaszewski, K. A. et al. Degeneration and calcification of the cervical endplate is connected with decreased expression of ANK, ENPP-1, OPN and TGF-beta1 in the intervertebral disc. Pol. J. Pathol. 65, 210–217 (2014).
Xiao, Z. F. et al. Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice. Arthritis Res. Ther. 20, 207 (2018).
Article PubMed PubMed Central Google Scholar
Zhou, T. F. et al. Spatiotemporal characterization of human early intervertebral disc formation at single-cell resolution. Adv. Sci. 10, e2206296 (2023).
Cherif, H. et al. Single-cell RNA-Seq analysis of cells from degenerating and non-degenerating intervertebral discs from the same individual reveals new biomarkers for intervertebral disc degeneration. Int. J. Mol. Sci. 23, 3993 (2022).
Article CAS PubMed PubMed Central Google Scholar
Li, W. et al. Revealing the key MSCs niches and pathogenic genes in influencing CEP homeostasis: a conjoint analysis of single-cell and WGCNA. Front. Immunol. 13, 933721 (2022).
Article CAS PubMed PubMed Central Google Scholar
Liang, T. et al. Constructing intervertebral disc degeneration animal model: a review of current models. Front. Surg. 9, 1089244 (2022).
Rajasekaran, S., Venkatadass, K., Naresh Babu, J., Ganesh, K. & Shetty, A. P. Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs: results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs. Eur. Spine J. 17, 626–643 (2008).
留言 (0)