Background: We aimed to identify biomarkers in breath analysis with MCC-IMS to monitor the haemodialysis for CKD patients fast and non-invasive. Material & methods: Six patients′ breath was analysed via MCC-IMS before and after dialysis and compared to blood plasma samples analysed via UPLC-FLD for potential renal failure biomarkers. Additionally, breath from six healthy control persons was analysed. Results: Phenol was found as a breath marker for CKD. For three patients the phenol concentration in breath and plasma was elevated before and decreased during dialysis and reached values in the range of healthy control persons. Conclusion: This study shows that the measurement of phenol via breath analysis could be used to monitor the haemodialysis for CKD-patients and might also be usable for the calculation of haemodialysis dose in the future. Keywords: Chronic kidney disease, breath analysis, breath marker, ion mobility spectrometry, MCC IMS, phenol

B.T. has received research grants from Evotec SE and CSL Vifor, all unrelated to this paper. B.T. has received honoraria and travel support from CSL Vifor, all unrelated to this paper. T.P. has a BMBF project under the number 03RU1U092G and received honoraria via the institution from TSC Int. NL for lectures, all unrelated to this paper. All other authors do not have any conflicts of interest.

DRKS00029679

This study did not receive any funding

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