YCU Center for Novel and Exploratory Clinical Trials, Yokohama City University Hospital, 1-1- 1 Fukuura, Yokohama, Kanagawa, Japan

Reo Tanoshima, Naoko Inagaki, Manabu Nitta, Soichiro Sue, Tatsuya Haze, Kotaro Senuki, Chihiro Sano, Hajime Takase, Akito Nozaki, Kozo Okada, Atsushi Kawaguchi, Yusuke Kobayashi & Etsuko Miyagi

Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Japan

Reo Tanoshima, Sayuri Shimizu & Makoto Kaneko

Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Naoko Inagaki, Soichiro Sue & Shin Maeda

Department of Cardiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Manabu Nitta

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Tatsuya Haze

Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan

Hajime Takase

Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan

Akito Nozaki

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan

Kozo Okada

Medical Care Bureau, Yokohama City, Yokohama, Japan

Kohei Ohyama

Department of Pediatrics, St. Marianna University, Kawasaki, Japan

Atsushi Kawaguchi

Department of Anesthesia, Yokohama City University, Yokohama, Japan

Atsushi Kawaguchi

CHU Sainte Justine Research Centre, University of Montreal, Montreal, Canada

Atsushi Kawaguchi

Department of Clinical Data Science, Clinical Research and Education Promotion Division, National Center of Neurology and Psychiatry, Tokyo, Japan

Hideki Oi

NCD Epidemiology Research Center (NERC), Shiga University of Medical Science, Shiga, Japan

Yuichiro Yano

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan

Yuichiro Yano

Kitasato Clinical Research Center, School of Medicine, Kitasato University, Sagamihara, Japan

Yuji Kumagai

Department of Obstetrics and Gynecology, Yokohama City University Hospital, Yokohama, Japan

Etsuko Miyagi

RT, NI, KS, and CS, designed the research. RT, NI, MN, S Sue, S Shimizu, TH, KS, CS, HT, MK, AN, K Okada, K Ohyama, AK, YK, HO, SM, YY, YK, EM participated in the discussion. RT wrote the initial manuscript. All authors read and confirmed the final version of the manuscript.