Abushakra, S., Porsteinsson, A. P., Sabbagh, M., Bracoud, L., Schaerer, J., Power, A., Hey, J. A., Scott, D., Suhy, J., Tolar, M., Alzheimer’s Disease Neuroimaging Initiative. (2020). APOE ε4/ε4 homozygotes with early Alzheimer’s disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. Alzheimer’s & Dementia (NY), 6(1), e12117. https://doi.org/10.1002/trc2.12117

Article  Google Scholar 

Altmann, A., Tian, L., Henderson, V. W., Greicius, M. D., & Investigators, A. D. N. I. (2014). Sex modifies the APOE-related risk of developing Alzheimer disease. Annals of Neurology, 75(4), 563–573.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alzheimer’s Association. (2022). 2022 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 18(4), 700–789.

Article  Google Scholar 

Burggren, A. C., Zeineh, M. M., Ekstrom, A. D., Braskie, M. N., Thompson, P. M., Small, G. W., & Bookheimer, S. Y. (2008). Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers. NeuroImage, 41(4), 1177–1183.

Article  CAS  PubMed  Google Scholar 

Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215–222. https://doi.org/10.1016/s1364-6613(00)01483-2

Article  CAS  PubMed  Google Scholar 

Dale, A. M., & Sereno, M. I. (1993). Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: A linear approach. Journal of Cognitive Neuroscience, 5(2), 162–176.

Article  CAS  PubMed  Google Scholar 

Dale, A. M., Fischl, B., & Sereno, M. I. (1999). Cortical surface-based analysis I. Segmentation and Surface Reconstruction. Neuroimage, 9(2), 179–194. https://doi.org/10.1006/nimg.1998.0395

Article  CAS  PubMed  Google Scholar 

de Godoy, L. L., Alves, C. A. P. F., Saavedra, J. S. M., Studart-Neto, A., Nitrini, R., da Costa Leite, C., & Bisdas, S. (2021). Understanding brain resilience in superagers: A systematic review. Neuroradiology, 63(5), 663–683. https://doi.org/10.1007/s00234-020-02562-1

Article  PubMed  Google Scholar 

Donix, M., Burggren, A. C., Suthana, N. A., Siddarth, P., Ekstrom, A. D., Krupa, A. K., Jones, M., Rao, A., Martin-Harris, L., Ercoli, L. M., Miller, K. J., Small, G. W., & Bookheimer, S. Y. (2010). Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism. NeuroImage, 53(1), 37–43.

Article  CAS  PubMed  Google Scholar 

Donix, M., Small, G. W., & Bookheimer, S. Y. (2012). Family history and APOE-4 genetic risk in Alzheimer’s disease. Neuropsychology Review, 22(3), 298–309.

Article  PubMed  PubMed Central  Google Scholar 

Dowell, N. G., Evans, S. L., Tofts, P. S., King, S. L., Tabet, N., & Rusted, J. M. (2016). Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers. NMR in Biomedicine, 29(5), 614–624. https://doi.org/10.1002/nbm.3502

Article  CAS  PubMed  Google Scholar 

Eskildsen, S. F., Coupé, P., García-Lorenzo, D., Fonov, V., Pruessner, J. C., Collins, D. L., Alzheimer’s Disease Neuroimaging Initiative. (2013). Prediction of Alzheimer’s disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning. NeuroImage, 65, 511–521.

Article  PubMed  Google Scholar 

Espeseth, T., Westlye, L. T., Fjell, A. M., Walhovd, K. B., Rootwelt, H., & Reinvang, I. (2008). Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E ε4. Neurobiology of Aging, 29(3), 329–340.

Article  CAS  PubMed  Google Scholar 

Ewers, M. (2020). Reserve in Alzheimer’s disease: Update on the concept, functional mechanisms and sex differences. Current Opinion in Psychiatry, 33(2), 178–184. https://doi.org/10.1097/YCO.0000000000000574

Article  PubMed  Google Scholar 

Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R., Myers, R. H., Pericak-Vance, M. A., Risch, N., & van Duijn, C. M. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA, 278(16), 1349–1356.

Fennema-Notestine, C., Panizzon, M. S., Thompson, W. R., Chen, C. H., Eyler, L. T., Fischl, B., Franz, C. E., Grant, M. D., Jak, A. J., Jernigan, T. L., Lyons, M. J., Neale, M. C., Seidman, L. J., Tsuang, M. T., Xian, H., Dale, A. M., & Kremen, W. S. (2011). Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age. Journal of Alzheimer’s Disease, 26(3), 49–60.

Article  PubMed  PubMed Central  Google Scholar 

Fischl, B., & Dale, A. M. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 97(20), 11050–11055. https://doi.org/10.1073/pnas.200033797

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fischl, B., Liu, A., & Dale, A. M. (2001). Automated manifold surgery: Constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Transactions on Medical Imaging, 20(1), 70–80. https://doi.org/10.1109/42.906426

Article  CAS  PubMed  Google Scholar 

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. https://doi.org/10.1016/0022-3956(75)90026-6

Article  CAS  PubMed  Google Scholar 

Gefen, T., Shaw, E., Whitney, K., Martersteck, A., Stratton, J., Rademaker, A., Weintraub, S., Mesulam, M. M., & Rogalski, E. (2014). Longitudinal neuropsychological performance of cognitive SuperAgers. Journal of the American Geriatrics Society, 62(8), 1598–1600. https://doi.org/10.1111/jgs.12967

Article  PubMed  PubMed Central  Google Scholar 

Gutiérrez-Galve, L., Lehmann, M., Hobbs, N. Z., Clarkson, M. J., Ridgway, G. R., Crutch, S., Ourselin, S., Schott, J. M., Fox, N. C., & Barnes, J. (2009). Patterns of cortical thickness according to APOE genotype in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 28(5), 476–485.

Article  PubMed  Google Scholar 

Harrison, T. M., Weintraub, S., Mesulam, M. M., & Rogalski, E. (2012). Superior memory and higher cortical volumes in unusually successful cognitive aging. Journal of the International Neuropsychological Society : JINS, 18(6), 1081–1085. https://doi.org/10.1017/S1355617712000847

Article  PubMed  Google Scholar 

Harrison, T. M., Maass, A., Baker, S. L., & Jagust, W. J. (2018). Brain morphology, cognition, and β-amyloid in older adults with superior memory performance. Neurobiology of Aging, 67, 162–170. https://doi.org/10.1016/j.neurobiolaging.2018.03.024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hays, C. C., Zlatar, Z. Z., Meloy, M. J., Osuna, J., Liu, T. T., Galasko, D. R., & Wierenga, C. E. (2020). Anterior cingulate structure and perfusion is associated with cerebrospinal fluid tau among cognitively normal older adult APOEɛ4 carriers. Journal of Alzheimer’s Disease: JAD, 73(1), 87–101. https://doi.org/10.3233/JAD-190504

Article  CAS  PubMed  Google Scholar 

Huang, W., Zeng, J., Jia, L., Zhu, D., O’Brien, J., Ritchie, C., Shu, N., & Su, L. (2023). Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adults. Brain Communications, 5(5), fcad234. https://doi.org/10.1093/braincomms/fcad234

Article  CAS  PubMed  PubMed Central  Google Scholar 

Im, K., Lee, J. M., Lee, J., Shin, Y. W., Kim, I. Y., Kwon, J. S., & Kim, S. I. (2006). Gender difference analysis of cortical thickness in healthy young adults with surface-based methods. NeuroImage, 31(1), 31–38.

Article  PubMed  Google Scholar 

Jurica, P.J., Leitten, C.L., & Mattis, S. (2001) DRS-2: Dementia Rating Scale-2: Professional Manual. Psychological Assessment Resources.

Kalpouzos, G., Chételat, G., Baron, J. C., Landeau, B., Mevel, K., Godeau, C., Barré, L., Constans, J. M., Viader, F., Eustache, F., & Desgranges, B. (2009). Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiology of Aging, 30(1), 112–124. https://doi.org/10.1016/j.neurobiolaging.2007.05.019

Article  CAS  PubMed  Google Scholar 

Khoury, M., Valcic, M., Churchill, N. W., Di Battista, A., De Luca, V., Fornazzari, L. R., ... & Schweizer, T. A. (2024). Sex differences in cortical thickness and neuropsychiatric symptom burden based on Apoe4 homozygosity in Alzheimer’s disease. Available at SSRN: https://doi.org/10.2139/ssrn.4733428

Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., van Belle, G., Jolley, L., & Larson, E. B. (2002). Dementia and Alzheimer disease incidence: A prospective cohort study. Archives of Neurology, 59(11), 1737–1746.

Article  PubMed  Google Scholar 

Le Heron, C., Apps, M. A. J., & Husain, M. (2018). The anatomy of apathy: A neurocognitive framework for amotivated behaviour. Neuropsychologia, 118(Pt B), 54–67.