Davern M, Donlon NE, Power R, et al. The tumour immune microenvironment in oesophageal cancer. Br J Cancer. 2021;125:479–94.

Article  PubMed  PubMed Central  Google Scholar 

An HJ, Koh HM, Lee JS, et al. Prognostic role of macrophage migration inhibitory factor in patients with clear cell renal cell carcinoma. Medicine. 2020;99:e23277.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Yung MMH, Ngan HYS, et al. The impact of the Tumor Microenvironment on Macrophage polarization in Cancer Metastatic Progression. IJMS. 2021;22:6560.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Li D, Cang H, et al. Crosstalk between cancer and immune cells: role of tumor-associated macrophages in the tumor microenvironment. Cancer Med. 2019;8:4709–21.

Article  PubMed  PubMed Central  Google Scholar 

Asiry S, Kim G, Filippou PS, et al. The Cancer Cell Dissemination Machinery as an immunosuppressive niche: a New Obstacle towards the era of Cancer Immunotherapy. Front Immunol. 2021;12:654877.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mills CD, Lenz LL, Harris RA. A breakthrough: Macrophage-Directed Cancer Immunotherapy. Cancer Res. 2016;76:513–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lazarov T, Juarez-Carreño S, Cox N, et al. Physiology and diseases of tissue-resident macrophages. Nature. 2023;618:698–707.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Liu R, Yu Q, et al. Metabolic reprogramming of macrophages during infections and cancer. Cancer Lett. 2019;452:14–22.

Article  CAS  PubMed  Google Scholar 

Lecoultre M, Dutoit V, Walker PR. Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review. J Immunother Cancer. 2020;8:e001408.

Article  PubMed  PubMed Central  Google Scholar 

Locati M, Curtale G, Mantovani A, Diversity. Mechanisms, and significance of macrophage plasticity. Annu Rev Pathol Mech Dis. 2020;15:123–47.

Article  CAS  Google Scholar 

Hourani T, Holden JA, Li W, et al. Tumor Associated macrophages: Origin, Recruitment, phenotypic diversity, and Targeting. Front Oncol. 2021;11:788365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yunna C, Mengru H, Lei W, et al. Macrophage M1/M2 polarization. Eur J Pharmacol. 2020;877:173090.

Article  PubMed  Google Scholar 

Zhang Q, Sioud M. Tumor-Associated Macrophage subsets: shaping polarization and targeting. IJMS. 2023;24:7493.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Tokumaru Y, Asaoka M, et al. M1 macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer. Sci Rep. 2020;10:16554.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang F, Zhang S, Jeon R, et al. Interferon Gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity. EBioMedicine. 2018;30:303–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu K, Zhao E, Ilyas G, et al. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy. 2015;11:271–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Dong Y, Di S, et al. Tumor associated macrophages in esophageal squamous carcinoma: promising therapeutic implications. Biomed Pharmacother. 2023;167:115610.

Article  CAS  PubMed  Google Scholar 

Schweer D, McAtee A, Neupane K, et al. Tumor-Associated macrophages and Ovarian Cancer: implications for Therapy. Cancers. 2022;14:2220.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Li H, Wu Q, et al. Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth. Redox Biol. 2019;22:101116.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi L, Chen J, Yang Y, et al. Hypoxia correlates with poor survival and M2 macrophage infiltration in Colorectal Cancer. Front Oncol. 2020;10:566430.

Article  PubMed  PubMed Central  Google Scholar 

Boutilier AJ, Elsawa SF. Macrophage polarization States in the Tumor Microenvironment. IJMS. 2021;22:6995.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadhukhan P, Seiwert TY. The role of macrophages in the tumor microenvironment and tumor metabolism. Semin Immunopathol. 2023;45:187–201.

Article  PubMed  Google Scholar 

Zhang J, Zhou X, Hao H. Macrophage phenotype-switching in cancer. Eur J Pharmacol. 2022;931:175229.

Article  CAS  PubMed  Google Scholar 

Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44:450–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mills CD. Anatomy of a Discovery: M1 and M2 Macrophages. Front Immunol. 2015;6. http://journal.frontiersin.org/Article/10.3389/fimmu.2015.00212/abstract. Cited 8 Oct  2023.

Chen D, Zhang X, Li Z, et al. Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages. Theranostics. 2021;11:1016–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Den Bossche J, Baardman J, De Winther MPJ. Metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time Extracellular Flux Analysis. JoVE. 2015;105:53424.

Google Scholar 

Jha AK, Huang SC-C, Sergushichev A, et al. Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that regulate macrophage polarization. Immunity. 2015;42:419–30.

Article  CAS  PubMed  Google Scholar 

Liu P-S, Wang H, Li X, et al. α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18:985–94.

Article  CAS  PubMed  Google Scholar 

Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature. 2007;447:1116–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen H, Liu J, Chen S, et al. Prognostic Value of Tumor-Associated macrophages in Clear Cell Renal Cell Carcinoma: a systematic review and Meta-analysis. Front Oncol. 2021;11:657318.

Article  CAS