HIV and AIDS. Available from: https://www.who.int/news-room/fact-sheets/detail/hiv-aids

New WHO guidance on HIV viral suppression and scientific updates released at IAS 2023. Available from: https://www.who.int/es/news/item/23-07-2023-new-who-guidance-on-hiv-viral-suppression-and-scientific-updates-released-at-ias-2023

EACS European AIDS Clinical Society 1 EACS Guidelines 12.0.

HIV Clinical Guidelines: Adult and Adolescent ARV - What’s New in the Guidelines | Clinicalinfo.HIV.gov. Available from: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/whats-new

Yu H, Yang Y, Cao D, Zhao Y, Jin C, Sun H, et al. Association of low-level viremia with mortality among people living with HIV on antiretroviral therapy in Dehong, Southwest China: a retrospective cohort study. HIV Med. 2023;24(1):37–45.

Article  CAS  PubMed  Google Scholar 

Hermans LE, Moorhouse M, Carmona S, Grobbee DE, Hofstra LM, Richman DD, et al. Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study. Lancet Infect Dis. 2018;18(2):188–97.

Article  PubMed  Google Scholar 

Taiwo B, Gallien S, Aga E, Ribaudo H, Haubrich R, Kuritzkes DR, et al. Antiretroviral drug resistance in HIV-1-infected patients experiencing persistent low-level viremia during first-line therapy. J Infect Dis. 2011;204(4):515–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sokoya T, Steel HC, Nieuwoudt M, Rossouw TM. HIV as a Cause of immune activation and immunosenescence. Mediators Inflamm. 2017. https://doi.org/10.1155/2017/6825493.

Article  PubMed  PubMed Central  Google Scholar 

Bestilny LJ, Gill MJ, Mody CH, Riabowol KT. Accelerated replicative senescence of the peripheral immune system induced by HIV infection. AIDS. 2000;14(7):771–80.

Article  CAS  PubMed  Google Scholar 

White JA, Wu F, Yasin S, Moskovljevic M, Varriale J, Dragoni F, et al. Clonally expanded HIV-1 proviruses with 5’-leader defects can give rise to nonsuppressible residual viremia. J Clin Invest. 2023. https://doi.org/10.1172/JCI165245.

Article  PubMed  PubMed Central  Google Scholar 

Okada R, Kondo T, Matsuki F, Takata H, Takiguchi M. Phenotypic classification of human CD4+ T cell subsets and their differentiation. Int Immunol. 2008;20(9):1189–99.

Article  CAS  PubMed  Google Scholar 

Koch S, Larbi A, Derhovanessian E, Özcelik D, Naumova E, Pawelec G. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing. 2008;25:5.

Google Scholar 

Mojumdar K, Vajpayee M, Chauhan NK, Singh A, Singh R, Kurapati S. Altered T cell differentiation associated with loss of CD27 and CD28 in HIV infected Indian individuals. Cytometry B Clin Cytom. 2012;82B(1):43–53.

Article  CAS  Google Scholar 

Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GMA, Papagno L, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8(4):379–85.

Article  CAS  PubMed  Google Scholar 

Appay V, Nixon DF, Donahoe SM, Gillespie GMA, Dong T, King A, et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med. 2000;192(1):63–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Champagne P, Ogg GS, King AS, Knabenhans C, Ellefsen K, Nobile M, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410(6824):106–11.

Article  CAS  PubMed  Google Scholar 

Mueller YM, De Rosa SC, Hutton JA, Witek J, Roederer M, Altman JD, et al. Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells. Immunity. 2001;15(6):871–82.

Article  CAS  Google Scholar 

Breen EJ, Polaskova V, Khan A. Bead-based multiplex immuno-assays for cytokines, chemokines, growth factors and other analytes: median fluorescence intensities versus their derived absolute concentration values for statistical analysis. Cytokine. 2015;71(2):188–98.

Article  CAS  PubMed  Google Scholar 

Shapiro MR, Dong X, Perry DJ, McNichols JM, Thirawatananond P, Posgai AL, et al. Human immune phenotyping reveals accelerated aging in type 1 diabetes. JCI Insight. 2023. https://doi.org/10.1172/jci.insight.170767.

Article  PubMed  PubMed Central  Google Scholar 

Pearce N. Analysis of matched case-control studies. BMJ. 2016;25:352.

Google Scholar 

Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, et al. HIV preferentially infects HIV-specific CD4+ T cells. Nature. 2002;417(6884):95–8.

Article  CAS  PubMed  Google Scholar 

Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, et al. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol. 2004;2(2):e20–e20.

Article  PubMed  PubMed Central  Google Scholar 

Grabmeier-Pfistershammer K, Stecher C, Zettl M, Rosskopf S, Rieger A, Zlabinger GJ, et al. Antibodies targeting BTLA or TIM-3 enhance HIV-1 specific T cell responses in combination with PD-1 blockade. Clin Immunol. 2017;1(183):167–73.

Article  Google Scholar 

Yue FY, Kovacs CM, Dimayuga RC, Parks P, Ostrowski MA. HIV-1-specific memory CD4+ T cells are phenotypically less mature than cytomegalovirus-specific memory CD4+ T cells. J Immunol. 2004;172(4):2476–86.

Article  CAS  PubMed  Google Scholar 

Goicoechea M, Smith DM, Liu L, May S, Tenorio AR, Ignacio CC, et al. Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infect Dis. 2006;194(1):29–37.

Article  PubMed  Google Scholar 

Tiba F, Nauwelaers F, Sangaré L, Coulibaly B, Kräusslich HG, Böhler T. Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study. J Int AIDS Soc. 2011;14(1):57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han J, Mu W, Zhao H, Hao Y, Song C, Zhou H, et al. HIV-1 low-level viremia affects T cell activation rather than T cell development in school-age children, adolescents, and young adults during antiretroviral therapy. Int J Infect Dis. 2020;1(91):210–7.

Article  Google Scholar 

Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med. 2008;205(12):2763–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006;443(7109):350–4.

Article  CAS  PubMed  Google Scholar 

Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, Bessette B, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med. 2006;12(10):1198–202.

Article  CAS  PubMed  Google Scholar 

Paris RM, Petrovas C, Ferrando-Martinez S, Moysi E, Boswell KL, Archer E, et al. Selective loss of early differentiated, highly functional pd1high CD4 T cells with HIV progression. PLoS ONE. 2015;10(12): e0144767.

Article  PubMed  PubMed Central  Google Scholar 

Ramljak D, Vukoja M, Curlin M, Vukojevic K, Barbaric M, Glamoclija U, et al. Early response of CD8+ T cells in COVID-19 patients. J Pers Med. 2021. https://doi.org/10.3390/jpm11121291.

Article  PubMed  PubMed Central  Google Scholar 

Felix J, Lambert J, Roelens M, Maubec E, Guermouche H, Pages C, et al. Ipilimumab reshapes T cell memory subsets in melanoma patients with clinical response. Oncoimmunology. 2016;5:7.

Article  Google Scholar 

Wistuba-Hamprecht K, Martens A, Heubach F, Romano E, Geukes Foppen M, Yuan J, et al. Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients. Eur J Cancer. 2017;1(73):61–70.

Article  Google Scholar 

de Jong LC, Crnko S, ten Broeke T, Bovenschen N. Noncytotoxic functions of killer cell granzymes in viral infecti