Ethical approval

Ethical approval was provided by the following institutions: private practice of Dr. Raymond Douglas, Byers Eye Institute, private practice of Dr. Kimberly Cockerham, and Concord Eye Center. All procedures performed in studies involving human participants were in accordance with the ethical standards of the private practice of Dr. Raymond Douglas, Byers Eye Institute, private practice of Dr. Kimberly Cockerham, Concord Eye Center, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by all the sites’ institutional review boards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

Shoaib Ugradar is consultant for Jenssen, Acelyrin, and Viridian Therapeutics, previous consultant for Amgen. Raymond Douglas is an employee of Sling Therapeutics. Kimberly Cockerham is a consultant for Amgen (formerly Horizon Therapeutics), Viridian Pharmaceuticals and 3T Ophthalmics. Andrea Kossler is a consultant for Amgen (Horizon Therapeutics). David Weinberg is a consultant for Amgen (formerly Horizon Therapeutics). All other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.