Finn RS, Qin S, Ikeda M, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N Engl J Med. 2020;382:1894–905.
Article CAS PubMed Google Scholar
Cheng A-L, Qin S, Ikeda M, et al. Updated efficacy and safety data from IMbrave150: Atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma. J Hepatol. 2022;76:862–73.
Article CAS PubMed Google Scholar
El-Serag HB, Lenhard Rudolph K. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–76.
Article CAS PubMed Google Scholar
Iwakiri Y. Pathophysiology of portal hypertension. Clin Liver Dis. 2014;18:281–91.
Article PubMed PubMed Central Google Scholar
Furusawa A, Naganuma A, Suzuki Y, et al. Two cases of rapid progression of esophageal varices after atezolizumab–bevacizumab treatment for hepatocellular carcinoma. Clin J Gastroenterol. 2022;15:451–9.
Suzuki H, Iwamoto H, Shimose S, et al. Case report: exacerbation of varices following atezolizumab plus bevacizumab treatment of hepatocellular carcinoma: a case series and literature review. Front Oncol. 2022;12:948293.
Article PubMed PubMed Central Google Scholar
Tsuruoka M, Inoue J, Ouchi K, et al. Duodenal variceal rupture during atezolizumab and bevacizumab treatment for hepatocellular carcinoma. Intern Med. 2023;62:1467–72.
Ha Y, Kim JH, Cheon J, et al. Risk of variceal bleeding in patients with advanced hepatocellular carcinoma receiving Atezolizumab/Bevacizumab. Clin Gastroenterol Hepatol. 2023;21:2421–3.
de Franchis R, Faculty BVI. Expanding consensus in portal hypertension: report of the Baveno VI consensus workshop: stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015;63:743–52.
Garcia-Tsao G, Abraldes JG, Berzigotti A, et al. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American association for the study of liver diseases. Hepatology. 2017;65:310–35.
Simon-Talero M, Roccarina D, Martínez J, et al. Association between portosystemic shunts and increased complications and mortality in patients with cirrhosis. Gastroenterology. 2018;154:1694–705.
Nardelli S, Riggio O, Gioia S, et al. Spontaneous porto-systemic shunts in liver cirrhosis: clinical and therapeutical aspects. World J Gastroenterol. 2020;26:1726–32.
Article PubMed PubMed Central Google Scholar
Ohnishi K, Sato S, Saito M, et al. Clinical and portal hemodynamic features in cirrhotic patients having a large spontaneous splenorenal and/or gastrorenal shunt. Am J Gastroenterol. 1986;81:450–5.
Garcia J, Hurwitz HI, Sandler AB, et al. Bevacizumab (Avastin®) in cancer treatment: a review of 15 years of clinical experience and future outlook. Cancer Treat Rev. 2020. https://doi.org/10.1016/j.ctrv.2020.102017.
Roviello G, Bachelot T, Hudis CA, et al. The role of bevacizumab in solid tumours: a literature based meta-analysis of randomised trials. Eur J Cancer. 2017;75:245–58.
Article CAS PubMed Google Scholar
Chinot OL, Wick W, Mason W, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014;370:709–22.
Article CAS PubMed Google Scholar
Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370:699–708.
Article CAS PubMed PubMed Central Google Scholar
Funyu J, Mochida S, Inao M, et al. VEGF can act as vascular permeability factor in the hepatic sinusoids through upregulation of porosity of endothelial cells. Biochem Biophys Res Commun. 2001;280:481–5.
Article CAS PubMed Google Scholar
DeLeve LD, Wang X, Hu L, et al. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 2004;287:757–63.
Moreau R. VEGF-induced angiogenesis drives collateral circulation in portal hypertension. J Hepatol. 2005;43:6–8.
Article CAS PubMed Google Scholar
Ferrara N, Hillan KJ, Novotny W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun. 2005;333:328–35.
Article CAS PubMed Google Scholar
Sugiyama T, Mizuno M, Aoki Y, et al. A single-arm study evaluating bevacizumab, cisplatin, and paclitaxel followed by single agent bevacizumab in Japanese patients with advanced cervical cancer. Jpn J Clin Oncol. 2017;47:39–46.
Article PubMed PubMed Central Google Scholar
Avastin prescribing information. http:// www. gene. com/ gene/ products/ information/ pdf/ avastin-prescribing. pdf. Accessed 10 Jan 2022.
Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. AnnSurg. 1968;167:324–8.
Goforth P, Gudas CJ. Effects of steroids on wound healing: a review of the literature. J Foot Surg. 1980;19:22–8.
Oxlund H, Fogdestam I, Viidik A. The influence of cortisol on wound healing of the skin and distant connective tissue response. Surg Gynecol Obstet. 1979;148:876–80.
Wang AS, Armstrong AW, Armstrong EJ. Corticosteroids and wound healing: clinical considerations in the perioperative period. Am J Surg. 2013;206:410–7.
Article CAS PubMed Google Scholar
Tada F, Hiraoka A, Tada T, et al. Efficacy and safety of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma patients with esophageal–gastric varices. J Gastroenterol. 2023;58:1134–43.
Article CAS PubMed Google Scholar
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515:563–7.
Article CAS PubMed PubMed Central Google Scholar
Hsu C, Rimassa L, Sun HC, et al. Immunotherapy in hepatocellular carcinoma: evaluation and management of adverse events associated with atezolizumab plus bevacizumab. Ther Adv Med Oncol. 2021. https://doi.org/10.1177/17588359211031141.
Article PubMed PubMed Central Google Scholar
Honma Y, Shibata M, Gohda T, et al. Rapid progression of liver fibrosis induced by acute liver injury due to immune-related adverse events of atezolizumab. Intern Med. 2021;60:1847–53.
Article PubMed PubMed Central Google Scholar
Imoto K, Kohjima M, Hioki T, et al. Clinical features of liver injury induced by immune checkpoint inhibitors in Japanese patients. Can J Gastroenterol Hepatol. 2019. https://doi.org/10.1155/2019/6391712.
Article PubMed PubMed Central Google Scholar
De Martin E, Michot JM, Papouin B, et al. Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors. J Hepatol. 2018;68:1181–90.
Fujiwara K, Kondo T, Fujimoto K, et al. Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma. J Gastroenterol. 2024;59:515–25.
留言 (0)