Long J, Song J, Zhong L, Liao Y, Liu LL, Li X. Palmatine: a review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019;162:176–84.

Article  CAS  PubMed  Google Scholar 

Huong NT, Hop NQ, Son NT. The genus Cratoxylum: traditional use, phytochemistry and pharmacology. J Pharm Pharmacol. 2023;75:1259–93.

Article  PubMed  Google Scholar 

Van CA, Son NT. The mushroom Albatrelus confluens: a minireview on phytochemistry, biosynthesis, synthesis and pharmacological activities. Curr Top Med Chem. 2024;24:487–502.

Article  CAS  Google Scholar 

Manske RHF, Tomita M, Fujitani K, Okamoto Y. Studies on the alkaloids of Menispermaceous plants. CCXIX.*3 Dauricine from Menispermum canadense L. Chem Pharm Bull. 1965;13:1476–7.

Article  CAS  Google Scholar 

Mukherjee PK, Mukherjee D, Maji AK, Rai S, Michael H. The sacred lotus (Nelumbo nucifera) – phytochemical and therapeutic profile. J Pharm Pharmacol. 2009;61:407–22.

Article  CAS  PubMed  Google Scholar 

Quan ZJ, Dian ZF, Jia HC Protective and anti-arrhythmic effects of dauricine and verapamil on acute myocardial infarction in anesthetized dogs. Acta Pharmacol Sin. 1992;13:249–51.

Yang Z, Li C, Wang X, Zhai C, Yi Z, Wang L, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-κB signaling pathway in colon cancer cells. J Cell Physiol. 2010;225:266–75.

Article  CAS  PubMed  Google Scholar 

Yang XY, Liu QN, Zhang L, Jiang SQ, Gong PL. Neuroprotective effect of dauricine after transient middle cerebral artery occlusion in rats: Involvement of Bcl-2 family proteins. Am J Chin Med. 2010;38:307–18.

Article  CAS  PubMed  Google Scholar 

Li W, Qiu Y, Hao J, Zhao C, Deng X, Shu G. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018;121:156–65.

Article  CAS  PubMed  Google Scholar 

Li H, Chen X, Zhou SJ. Dauricine combined with clindamycin inhibits severe pneumonia co-infected by influenza virus H5N1 and Streptococcus pneumoniae in vitro and in vivo through NF-κB signaling pathway. J Pharmacol Sci. 2018;137:12–9.

Article  CAS  PubMed  Google Scholar 

Peng C, Fu X, Wang K, Chen L, Luo B, Huang N, et al. Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol. 2022;914:174461.

Article  CAS  PubMed  Google Scholar 

Zhang X, Wang T, Miao Y, Lin W, Zhu L, Meng X, et al. Dauricine exhibits anti‐inflammatory property against acute ulcerative colitis via the regulation of NF‐κB pathway. Cell Biochem Funct. 2023;41:713–21.

Article  CAS  PubMed  Google Scholar 

Xia GQ, Zhu MP, Li JW, Huang H. An alkaloid from Menispermum dauricum, dauricine mediates Ca2+ influx and inhibits NF-κB pathway to protect chondrocytes from IL-1β-induced inflammation and catabolism. J Ethnopharmacol. 2024;321:117560.

Article  CAS  PubMed  Google Scholar 

Xia JS, Guo DL, Zhang Y, Zhou ZN, Zeng FD, Hu CJ. Inhibitory effects of dauricine on potassium currents in guinea pig ventricular myocytes. Acta Pharmacol Sin. 2000;21:60–64.

CAS  PubMed  Google Scholar 

Xia JS, Li Z, Dong JW, Tu H, Zeng FD. Dauricine-induced changes in monophasic action potentials and effective refractory period of rabbit left ventricle in situ. Acta Pharmacol Sin. 2002;23:371–5.

CAS  PubMed  Google Scholar 

Liu QN, Zhang L, Gong PL, Yang XY, Zeng FD. Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current. Can J Physiol Pharmacol. 2009;87:954–62.

Article  CAS  PubMed  Google Scholar 

Han FM, Peng ZH, Song W, Zhang HM, Zhu MM, Chen Y. Identification of dauricine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. J Chromatograph B. 2007;854:1–7.

Article  CAS  Google Scholar 

Wang Y, Zhong D, Chen X, Zheng J. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. Chem Res Toxicol. 2009;22:824–34.

Article  CAS  PubMed  Google Scholar 

Chen N, Ji YB, Song DX, Xu CR, Song H, Li J. Effects of dauricine concentration in asiatic moonseed by different extraction solvents and methods. Appl Mechanics Mater. 2013;411–414:3162–5.

Article  Google Scholar 

Lu W, Chen Y, Chen H, Chen X. Optimization of the micellar electrokinetic capillary chromatographic determination of dauricine and daurisoline in Rhizoma Menispermi and its herbal medicine using experimental design and radial basis function neural network. J Analytic Chem. 2013;68:525–31.

Article  Google Scholar 

Lee AY, Kim HS, Choi G, Kang YM, Kim HK. Optimization of ultrasonic-assisted extraction of daurisoline and dauricine from Menispermi rhizoma by response surface methodology. J Liq Chromatogr Relat Technol. 2015;38:1561–70.

Article  CAS  Google Scholar 

Luo H, Peng M, Ye H, Chen L, Peng A, Tang M, et al. Predictable and linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high performance counter-current chromatography. J Chromatograph. B. 2010;878:1929–33.

Article  CAS  Google Scholar 

Sugiomoto Y, Yoshida A, Uchida S, Inanaga S, Yamada Y. Dauricine production in cultured roots of Menispermum dauricum. Phytochemistry. 1994;36:679–83.

Article  Google Scholar 

Sugiomoto Y, Uchida S, Inanaga S, Kimura Y, Hashimoto M, Isogai A. Early steps of dauricine biosynthesis in cultured roots of Menispermum dauricum. Biosci Biotech Biochem. 1996;60:503–5.

Article  Google Scholar 

Law BYK, Chan WK, Xu SW, Wang JR, Bai LP, Liu L, et al. Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells. Sci Rep. 2014;4:5510.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu MY, Wang SF, Cai CZ, Tan JQ, Li M, Lu JJ, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017;8:77673–84.

Article  PubMed  PubMed Central  Google Scholar 

Tang XD, Zhou X, Zhou KY. Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1α protein accumulation and vascular endothelial growth factor expression in human breast cancer cells. Acta Pharmacol Sin. 2009;30:605–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye ZG, Wang JH, Sun AX, Liang AH, Xue BY, Li CY, et al. Potentiation of vincristine-induced apoptosis by tetrandrine, neferine and dauricine in the human mammary MCF-7 multidrug-resistant cells. Acta Pharmacol Sin. 2001;36:96–9.

CAS  Google Scholar 

Li H, Sun L, Jiang X, Yuan G, Liu Y. Dauricine enhances the sensitivity of 5-fluorouracil in human breast cancer MCF-7 cells. Pratical Oncol J. 2017;6:385–9.

Google Scholar 

Li M, Che N, Liu X, Xuan Y, Jin Y. Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages. Biochem Pharmacol. 2023;217:115838.

Article  CAS  PubMed  Google Scholar 

Deng B, Jiang XL, Tan ZB, Cai M, Deng SH, Ding WJ, et al. Dauricine inhibits proliferation and promotes death of melanoma cells via inhibition of Src/STAT3 signaling. Phytother Res. 2021;35:3836–384.

Article  CAS  PubMed  Google Scholar 

Liang J, Lei P, Su X, Gao J, Ren B, Zhang Y, et al. Dauricine inhibits non-small cell lung cancer development by regulating PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2 pathways in a FLT4-dependent manner. Curr Can Drug Targets. 2024 https://doi.org/10.2174/0115680096282997240101192452.

Liu C, Yang T, Cheng C, Huo J, Peng X, Zhang Y. Dauricine attenuates Oct4/sonic hedgehog co-activated stemness and induces reactive oxygen species-mediated mitochondrial apoptosis via AKT/β-catenin signaling in human neuroblastoma and glioblastoma stem-like cells. Phytother Res. 2024;38:131–46.

Article  CAS  PubMed  Google Scholar 

Jiang L, Guo T, Jiang Y, Liu P, Bai Y. Dauricine inhibits human pancreatic carcinoma cell proliferation through regulating miRNA. Mol Omics. 2021;17:630.

Article  CAS  PubMed  Google Scholar 

Zhang YB, Fei HX, Guo J, Zh