Madireddy S, Madireddy S. Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation. Brain Sci. 2023 13(5):784. [doi: 10.3390/brainsci13050784.] PMID: 37239256; PMCID: PMC10216584.

Kobylarek D, Iwanowski P, Lewandowska Z, Limphaibool N, Szafranek S, Labrzycka A, Kozubski W. Advances in the potential biomarkers of epilepsy. Front Neurol. 2019;10:685. [doi: 10.3389/fneur.2019.00685.] PMID: 31312171; PMCID: PMC6614180.

Fabisiak T, Patel M. Crosstalk between neuroinflammation and oxidative stress in epilepsy. Front Cell Dev Biol. 2022;10:976953. doi: 10.3389/fcell.2022.976953. PMID: 36035987; PMCID: PMC9399352.

Ilhan A, Aladag MA, Kocer A, Boluk A, Gurel A, Armutcu F. Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model. Brain Res Bull. 2005;65(6):495-9. doi: 10.1016/j.brainresbull.2005.02.027. Epub 2005 Mar 22. PMID: 15862921.

Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ. Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation. Proc Natl Acad Sci U S A. 2008;105(44):17151-6. doi: 10.1073/pnas.0806682105. Epub 2008 Oct 27. PMID: 18955701; PMCID: PMC2579393.

Banote RK, Akel S, Zelano J. Blood biomarkers in epilepsy. Acta Neurol Scand. 2022; 146(4):362-368. doi: 10.1111/ane.13616. Epub 2022 Apr 11. PMID: 35411571; PMCID: PMC9790299.

Borowicz-Reutt KK, Czuczwar SJ. Role of oxidative stress in epileptogenesis and potential implications for therapy. Pharmacol Rep. 2020;72(5):1218-1226. doi: 10.1007/s43440-020-00143-w. Epub 2020 Aug 31. PMID: 32865811; PMCID: PMC7550371.

Pottoo FH, Salahuddin M, Khan FA, Al Dhamen MA, Alsaeed WJ, Gomaa MS, Vatte C, Alomary MN. Combinatorial regimen of carbamazepine and imipramine exhibits synergism against grandmal epilepsy in rats: Inhibition of pro-inflammatory cytokines and PI3K/Akt/mTOR signaling pathway. Pharmaceuticals (Basel). 2021;14(11):1204. doi: 10.3390/ph14111204. PMID: 34832986; PMCID: PMC8624327.

Palazón-García R, Benavente-Valdepeñas AM. Botulinum Toxin: From Poison to Possible Treatment for Spasticity in Spinal Cord Injury. Int J Mol Sci. 2021;22(9):4886. doi: 10.3390/ijms22094886. PMID: 34063051; PMCID: PMC8125452.

Sim WS. Application of botulinum toxin in pain management. Korean J Pain. 2011 Mar;24(1):1-6. doi: 10.3344/kjp.2011.24.1.1. Epub 2011 Feb 25. PMID: 21390172; PMCID: PMC3049971.

Bröer S, Zolkowska D, Gernert M, Rogawski MA. Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat. Neuroscience. 2013;252:253-61. doi: 10.1016/j.neuroscience.2013.07.050. Epub 2013 Jul 29. PMID: 23906638; PMCID: PMC4530632.

Tsui JK. Botulinum toxin as a therapeutic agent. Pharmacol Ther. 1996;72(1):13-24. doi: 10.1016/s0163-7258(96)00091-5. PMID: 8981568.

Jensen DB, Klingenberg S, Dimintiyanova KP, Wienecke J, Meehan CF. Intramuscular Botulinum toxin A injections induce central changes to axon initial segments and cholinergic boutons on spinal motoneurones in rats. Sci Rep. 2020;10(1):893. doi: 10.1038/s41598-020-57699-z. PMID: 31964988; PMCID: PMC6972769.

Weise D, Weise CM, Naumann M. Central Effects of Botulinum Neurotoxin-Evidence from Human Studies. Toxins (Basel). 2019;11(1):21. doi: 10.3390/toxins11010021. PMID: 30621330; PMCID: PMC6356587.

Vinehout K, Tynes K, Sotelo MR, Hyngstrom AS, McGuire JR, Schmit BD. Changes in Cortical Activity in Stroke Survivors Undergoing Botulinum Neurotoxin Therapy for Treatment of Focal Spasticity. Front Rehabil Sci. 2021;2:735819. doi: 10.3389/fresc.2021.735819. PMID: 36188774; PMCID: PMC9397708.

Moskiewicz D, Mraz M, Chamela-Bilińska D. Botulinum toxin and dynamic splint restore grasping function after stroke: A case report. Int J Environ Res Public Health. 2023; 20(6):4873. doi: 10.3390/ijerph20064873. PMID: 36981781; PMCID: PMC10049400.

Delnooz CC, Pasman JW, Beckmann CF, van de Warrenburg BP. Task-free functional MRI in cervical dystonia reveals multi-network changes that partially normalize with Botulinum toxin. PLoS One. 2013;8(5):e62877. doi: 10.1371/journal.pone.0062877. PMID: 23650536; PMCID: PMC3641096.

Delnooz CC, Pasman JW, Beckmann CF, van de Warrenburg BP. Altered striatal and pallidal connectivity in cervical dystonia. Brain Struct Funct. 2015;220(1):513-23. doi: 10.1007/s00429-013-0671-y. Epub 2013 Nov 21. PMID: 24259114.

Pingel J, Pacolet A, Elfving B, Ledri LN. Intramuscular BOTOX/A injections cause an inflammatory response in the muscle tissue of rats. Eur. J. Inflamm. 2021; 19:1-10

Luvisetto S. Botulinum Neurotoxins in Central Nervous System: An Overview from Animal Models to Human Therapy. Toxins (Basel). 2021;13(11):751. doi: 10.3390/toxins13110751. PMID: 34822535; PMCID: PMC8622321.

Luvisetto S. Botulinum Neurotoxins in Central Nervous System: An Overview from Animal Models to Human Therapy. Toxins (Basel). 2021;13(11):751. doi: 10.3390/toxins13110751. PMID: 34822535; PMCID: PMC8622321.

Kim YJ, Kim JH, Lee KJ, Choi MM, Kim YH, Rhie GE, Yoo CK, Cha K, Shin NR. Botulinum neurotoxin type A induces TLR2-mediated inflammatory responses in macrophages. PLoS One. 2015;10(4):e0120840. doi: 10.1371/journal.pone.0120840. PMID: 25853816; PMCID: PMC4390353.

Kato K, Akaike N, Kohda T, Torii Y, Goto Y, Harakawa T, Ginnaga A, Kaji R, Kozaki S. Botulinum neurotoxin A2 reduces incidence of seizures in mouse models of temporal lobe epilepsy. Toxicon. 2013 Nov;74:109-15. doi: 10.1016/j.toxicon.2013.07.027. Epub 2013 Aug 15. PMID: 23954512.

Costantin L, Bozzi Y, Richichi C, Viegi A, Antonucci F, Funicello M, Gobbi M, Mennini T, Rossetto O, Montecucco C, Maffei L, Vezzani A, Caleo M. Antiepileptic effects of botulinum neurotoxin E. J Neurosci. 2005 Feb 23;25(8):1943-51. doi: 10.1523/JNEUROSCI.4402-04.2005. PMID: 15728834; PMCID: PMC6726074.

Park J, Park HJ. Botulinum toxin for the treatment of neuropathic pain. Toxins (Basel). 2017;9(9):260. doi: 10.3390/toxins9090260. PMID: 28837075; PMCID: PMC5618193.

Hong B, Yao LL, Hu XY. None detectable retrograde transport of Chinese botulinum toxin type A in mice by single intramuscular injection. Int J Clin Exp Med. 2015;8(9):15815-21. PMID: 26629081; PMCID: PMC4658970.

Yesudhas A, Roshan SA, Radhakrishnan RK, Abirami GPP, Manickam N, Selvaraj K, Elumalai G, Shanmugaapriya S, Anusuyadevi M, Kandasamy M. Intramuscular injection of BOTOX® boosts learning and memory in adult mice in association with enriched circulation of platelets and enhanced density of pyramidal neurons in the hippocampus. Neurochem Res. 2020;45(12):2856-2867. doi: 10.1007/s11064-020-03133-9. Epub 2020 Sep 24. PMID: 32974763.

Matak I, Riederer P, Lacković Z. Botulinum toxin's axonal transport from periphery to the spinal cord. Neurochem Int. 2012;61(2):236-9. doi: 10.1016/j.neuint.2012.05.001. Epub 2012 May 8. PMID: 22580329.

Zarnowska I, Luszczki JJ, Zarnowski T, Wlaz P, Czuczwar SJ, Gasior M. Proconvulsant effects of the ketogenic diet in electroshock-induced seizures in mice. Metab Brain Dis. 2017;32(2):351-358. doi: 10.1007/s11011-016-9900-4. Epub 2016 Sep 20. PMID: 27644408; PMCID: PMC5346421.

Samarghandian S, Rajabi S, Aschner M, Noferesti V, Farkhondeh T. Oxidative stress and apoptotic index modifications in the hippocampus of rat pups born to mothers exposed to buprenorphine during lactation. Toxicol Rep. 2022;9:2050-2054. doi: 10.1016/j.toxrep.2022.11.005. PMID: 36518388; PMCID: PMC9742962.

Ramazani N, Mahd Gharebagh F, Soleimanzadeh A, Arslan HO, Keles E, Gradinarska-Yanakieva DG, Arslan-Acaröz D, Zhandi M, Baran A, Ayen E, Dinç DA. The influence of L-proline and fulvic acid on oxidative stress and semen quality of buffalo bull semen following cryopreservation. Vet Med Sci. 2023;9(4):1791-1802. doi: 10.1002/vms3.1158. Epub 2023 May 17. PMID: 37197763; PMCID: PMC10357270.

Luszczki JJ, Wojda E, Andres-Mach M, Cisowski W, Glensk M, Glowniak K, Czuczwar SJ. Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study. Epilepsy Res. 2009;85(2-3):293-9. doi: 10.1016/j.eplepsyres.2009.03.027. Epub 2009 Apr 29. PMID: 19406619.

Fischer R, Maier O. Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev. 2015;2015:610813. doi: 10.1155/2015/610813. Epub 2015 Mar 5. PMID: 25834699; PMCID: PMC4365363.

Nieoczym D, Albera E, Kankofer M, Wlaź P. Maximal electroshock induces changes in some markers of oxidative stress in mice. J Neural Transm (Vienna). 2008;115(1):19-25. doi: 10.1007/s00702-007-0805-6. Epub 2007 Aug 31. PMID: 17728996.

Moradi Jafari A, Hassanpourezatti M. Influence of methadone on the anticonvulsant efficacy of valproate sodium gabapentin against maximal electroshock seizure in mice by regulation of brain MDA TNF-α. Front Neurol. 2022 Aug 23;13:920107. doi: 10.3389/fneur.2022.920107. PMID: 36081867; PMCID: PMC9445582.

Pieróg M, Socała K, Wyska E, Poleszak E, Wlaź P. Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice. Molecules. 2021;26(16):4841. doi: 10.3390/molecules26164841. PMID: 34443428; PMCID: PMC8398784.

Reiter RJ, Manchester LC, Tan DX. Neurotoxins: free radical mechanisms and melatonin protection. Curr Neuropharmacol. 2010;8(3):194-210. doi: 10.2174/157015910792246236. PMID: 21358970; PMCID: PMC3001213.

Montastruc J, Marque P, Moulis F, Bourg V, Lambert V, Durrieu G, Montastruc JL, Montastruc F. Adverse drug reactions of botulinum neurotoxin type A in children with cerebral palsy: a pharmaco-epidemiological study in VigiBase. Dev Med Child Neurol. 2017;59(3):329-334. doi: 10.1111/dmcn.13286. Epub 2016 Sep 28. PMID: 27682175.

Caleo M, Restani L. Exploiting Botulinum neurotoxins for the study of brain physiology and pathology. Toxins (Basel). 2018;10(5):175. doi: 10.3390/toxins10050175. PMID: 29693600; PMCID: PMC5983231.

Ho YH, Lin YT, Wu CW, Chao YM, Chang AY, Chan JY. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Biomed Sci. 2015;22(1):46. doi: 10.1186/s12929-015-0157-8. PMID: 26100815; PMCID: PMC4477313.

Lorigados Pedre L, Gallardo JM, Morales Chacón LM, Vega García A, Flores-Mendoza M, Neri-Gómez T, Estupiñán Díaz B, Cruz-Xenes RM, Pavón Fuentes N, Orozco-Suárez S. Oxidative Stress in Patients with Drug Resistant Partial Complex Seizure. Behav Sci (Basel). 2018;8(6):59. doi: 10.3390/bs8060059. PMID: 29890748; PMCID: PMC6027168.

Arai Y, Maeda S, Higuchi H, Tomoyasu Y, Shimada M, Miyawaki T. Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. Immunopharmacol Immunotoxicol. 2012;34(2):216-21. doi: 10.3109/08923973.2011.595417. Epub 2011 Aug 19. PMID: 21851322.

Yesudhas A, Radhakrishnan RK, Sukesh A, Ravichandran S, Manickam N, Kandasamy M. BOTOX® counteracts the innate anxiety-related behaviours in correlation with increased activities of key antioxidant enzymes in the hippocampus of ageing experimental mice. Biochem Biophys Res Commun. 2021;569:54-60. doi: 10.1016/j.bbrc.2021.06.071. Epub 2021 Jul 3. PMID: 34229123.

Maniu I, Costea R, Maniu G, Neamtu BM. Inflammatory Biomarkers in Febrile Seizure: A Comprehensive Bibliometric, Review and Visualization Analysis. Brain Sci. 2021;11(8):1077. doi: 10.3390/brainsci11081077. PMID: 34439695; PMCID: PMC8394500.

Bigalke H, Heller I, Bizzini B, Habermann E. Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord. Naunyn Schmiedebergs Arch Pharmacol. 1981;316(3):244-51. doi: 10.1007/BF00505657. PMID: 6114440.

Drinovac V, Bach-Rojecky L, Lacković Z. Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. J Neural Transm (Vienna). 2014;121(6):665-9. doi: 10.1007/s00702-013-1150-6. Epub 2014 Jan 14. PMID: 24420081.

Pellett S, Tepp WH, Johnson EA. Botulinum neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations. FEBS Lett. 2019;593(18):2675-2685. doi: 10.1002/1873-3468.13508. Epub 2019 Jul 4. PMID: 31240706; PMCID: PMC7751886.

Ali DM, Abdelzaher WY, Abdel-Hafez S. Evaluation of the rivastigmine role against botulinum toxin-A-induced osteoporosis in albino rats: A biochemical, histological, and immunohistochemical study. Hum Exp Toxicol. 2018;37(12):1323-1335. doi: 10.1177/0960327118774941. Epub 2018 May 9. PMID: 29739252.