Connor S, Bermedo MS, World Palliative Care Alliance. World Health Organization global atlas of palliative care at the end of life. London: Worldwide Palliative Care Alliance; 2020.

Google Scholar 

Fassbender K, Fainsinger RL, Carson M, Finegan BA. Cost Trajectories at the end of life: the Canadian experience. J Pain Symptom Manage. 2009;38(1):75–80.

Article  PubMed  Google Scholar 

Howdon D, Rice N. Health care expenditures, age, proximity to death and morbidity: implications for an ageing population. J Health Econ. 2018;57:60–74.

Article  PubMed  Google Scholar 

Gomes B, Calanzani N, Curiale V, McCrone P, Higginson IJ, de Brito M. Effectiveness and cost-effectiveness of home palliative care services for adults with advanced illness and their caregivers. Cochrane Database Syst Rev. 2013;2013(6):CD007760.

PubMed  PubMed Central  Google Scholar 

Bajwah S, Oluyase AO, Yi D, Gao W, Evans CJ, Grande G, Todd C, Costantini M, Murtagh FE, Higginson IJ. The effectiveness and cost-effectiveness of hospital-based specialist palliative care for adults with advanced illness and their caregivers. Cochrane Database Syst Rev. 2020;9(9):CD012780.

PubMed  Google Scholar 

Singer AE, Goebel JR, Kim YS, Dy SM, Ahluwalia SC, Clifford M, Dzeng E, O’Hanlon CE, Motala A, Walling AM, et al. Populations and interventions for palliative and end-of-life care: a systematic review. J Palliat Med. 2016;19(9):995–1008.

Article  PubMed  PubMed Central  Google Scholar 

Zimmermann C, Riechelmann R, Krzyzanowska M, Rodin G, Tannock I. Effectiveness of specialized palliative care: a systematic review. JAMA. 2008;299(14):1698–709.

Article  CAS  PubMed  Google Scholar 

Gonzalez-Jaramillo V, Fuhrer V, Gonzalez-Jaramillo N, Kopp-Heim D, Eychmüller S, Maessen M. Impact of home-based palliative care on health care costs and hospital use: a systematic review. Palliat Support Care. 2021;19(4):474–87.

Article  PubMed  Google Scholar 

May P, Normand C, Cassel JB, Del Fabbro E, Fine RL, Menz R, Morrison CA, Penrod JD, Robinson C, Morrison RS. Economics of palliative care for hospitalized adults with serious illness: a meta-analysis. JAMA Intern Med. 2018;178(6):820–9.

Article  PubMed  PubMed Central  Google Scholar 

Quinn KL, Shurrab M, Gitau K, Kavalieratos D, Isenberg SR, Stall NM, Stukel TA, Goldman R, Horn D, Cram P, et al. Association of receipt of palliative care interventions with health care use, quality of life, and symptom burden among adults with chronic noncancer illness: a systematic review and meta-analysis. JAMA. 2020;324(14):1439–50.

Article  PubMed  PubMed Central  Google Scholar 

Bach PB, Schrag D, Begg CB. Resurrecting treatment histories of dead patients: a study design that should be laid to rest. JAMA. 2004;292(22):2765–70.

Article  CAS  PubMed  Google Scholar 

Popay J, Roberts H, Sowden A, Petticrew M, Arai L, Rodgers M, Britten N, Roen K, Duffy S. Guidance on the conduct of narrative synthesis in systematic reviews. Prod ESRC Methods Program Version. 2006;1(1):b92.

Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Connor SR, Bermedo M: Global atlas of palliative care at the end of life: Worldwide Palliative Care Alliance. London: World Health Organization; 2014.

Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press; 2015.

Google Scholar 

Harris I, Murray SA. Can palliative care reduce futile treatment? A systematic review. BMJ Support Palliat Care. 2013;3(4):389–98.

Article  PubMed  Google Scholar 

Janssens JP, Weber C, Herrmann FR, Cantero C, Pessina A, Matis C, Merlet Viollet R, Boiche-Brouillard L, Stirnemann J, Pautex S. Can early introduction of palliative care limit intensive care, emergency and hospital admissions in patients with severe chronic obstructive pulmonary disease? A pilot randomized study. Respiration. 2019;97(5):406–15.

Article  PubMed  Google Scholar 

Pattenden JF, Mason AR, Lewin RJP. Collaborative palliative care for advanced heart failure: outcomes and costs from the ‘Better Together’ pilot study. BMJ Support Palliat Care. 2013;3(1):69–76.

Article  PubMed  Google Scholar 

Slavin RE. Best evidence synthesis: an intelligent alternative to meta-analysis. J Clin Epidemiol. 1995;48(1):9–18.

Article  CAS  PubMed  Google Scholar 

Sahlen K-G, Boman K, Brännström M. A cost-effectiveness study of person-centered integrated heart failure and palliative home care: Based on a randomized controlled trial. Palliat Med. 2016;30(3):296–302.

Article  PubMed  Google Scholar 

Wong FKY, So C, Ng AYM, Lam P-T, Ng JSC, Ng NHY, Chau J, Sham MMK. Cost-effectiveness of a transitional home-based palliative care program for patients with end-stage heart failure. Palliat Med. 2018;32(2):476–84.

Article  PubMed  Google Scholar 

Higginson IJ, McCrone P, Hart SR, Burman R, Silber E, Edmonds PM. Is short-term palliative care cost-effective in multiple sclerosis? A randomized phase II trial. J Pain Symptom Manage. 2009;38(6):816–26.

Article  PubMed  Google Scholar 

Rosato R, Pagano E, Giordano A, Farinotti M, Ponzio M, Veronese S, Confalonieri P, Grasso MG, Patti F, Solari A. Living with severe multiple sclerosis: cost-effectiveness of a palliative care intervention and cost of illness study. Mult Scler Relat Disord. 2021;49:102756.

Article  PubMed  Google Scholar 

Gao W, Wilson R, Hepgul N, Yi D, Evans C, Bajwah S, Crosby V, Wilcock A, Lindsay F, Byrne A, et al. Effect of short-term integrated palliative care on patient-reported outcomes among patients severely affected with long-term neurological conditions: a randomized clinical trial. JAMA Netw Open. 2020;3(8):e2015061–e2015061.

Article  PubMed  PubMed Central  Google Scholar 

Phillips V, Quest TE, Higgins M, Marconi VC, Balthazar MS, Holstad M. A cost-effective analysis of motivational interviewing with palliative care versus usual care: results from the living well project. AIDS Behav. 2023;27(4):1259–68.

Article  PubMed  Google Scholar 

Evans CJ, Bone AE, Yi D, Gao W, Morgan M, Taherzadeh S, Maddocks M, Wright J, Lindsay F, Bruni C, et al. Community-based short-term integrated palliative and supportive care reduces symptom distress for older people with chronic noncancer conditions compared with usual care: a randomised controlled single-blind mixed method trial. Int J Nurs Stud. 2021;120:103978.

Article  PubMed  Google Scholar 

Kavalieratos D, Corbelli J, Zhang D, Dionne-Odom JN, Ernecoff NC, Hanmer J, Hoydich ZP, Ikejiani DZ, Klein-Fedyshin M, Zimmermann C, et al. Association between palliative care and patient and caregiver outcomes: a systematic review and meta-analysis. JAMA. 2016;316(20):2104–14.

Article  PubMed  PubMed Central  Google Scholar 

Luta X, Ottino B, Hall P, Bowden J, Wee B, Droney J, Riley J, Marti J. Evidence on the economic value of end-of-life and palliative care interventions: a narrative review of reviews. BMC Palliat Care. 2021;20:89.

Article  PubMed  PubMed Central  Google Scholar 

Smith S, Brick A, O’Hara S, Normand C. Evidence on the cost and cost-effectiveness of palliative care: a literature review. Palliat Med. 2014;28(2):130–50.

Article  PubMed  Google Scholar 

Dahabreh IJ, Sheldrick RC, Paulus JK, Chung M, Varvarigou V, Jafri H, Rassen JA, Trikalinos TA, Kitsios GD. Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes. Eur Heart J. 2012;33(15):1893–901.

Article  PubMed  PubMed Central  Google Scholar 

Parackal A, Ramamoorthi K, Tarride J-E. Economic evaluation of palliative care interventions: a review of the evolution of methods from 2011 to 2019. Am J Hosp Palliat Med. 2022;39(1):108–22.

Article  Google Scholar 

Briggs A. Economic evaluation and clinical trials: size matters. BMJ : British Medical Journal. 2000;321(7273):1362.

Article  CAS  PubMed  PubMed Central  Google Scholar