Document Type : original article

Authors

1 Division of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Pediatrics,Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Allergy and Clinical Immunology, Shiraz University of Medical Sciences, Shiraz, Iran

10.22038/ijp.2024.80040.5455

Abstract

Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rather newly described entity that can potentially end in multisystem failure in children following COVID-19 infection. The prognosis of patients with MIS-C is multifactorial; consequently, many risk factors increase the risk of mortality and severity of this disease. In this study we aimed to evaluate the prognostic effect of various parameters in mortality and intensive care unit admission of patients with MIS-C.

Methods and Materials: in this cross-sectional study, the information of patients with MIS-C in a one-year period in a tertiary pediatric center were extracted. The relationship between mortality and ICU admission of the patients with demographic information and lab data were assessed.

Results: a total of 88 male-predominant (56.8% vs. 43.2%, P=0.135) entered the study. Seven patients had expired and 71 patients were discharged from the hospital. In our study, demographic information of the patients and their lab data were not associated with mortality except for lactate dehydrogenase (LDH) level. All of the expired patients had elevated LDH, while only 53.1% of the discharged patients showed increased LDH (P=0.016). on the other hand, LDH did not differ between patients who were managed in ICUs and the ones who were managed in wards.

Conclusion: LDH can be counted as a prognostic tool for mortality in MIS-C and might be regarded as a part of evaluation of ICU admission in this disease.

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