Kolkhof P, Joseph A, Kintscher U. Nonsteroidal mineralocorticoid receptor antagonism for cardiovascular and renal disorders - New perspectives for combination therapy. Pharmacol Res. 2021;172:105859.

Article  CAS  PubMed  Google Scholar 

Ito S, Itoh H, Rakugi H, Okuda Y, Yoshimura M, Yamakawa S. Double-Blind Randomized Phase 3 Study Comparing Esaxerenone (CS-3150) and Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study). Hypertension. 2020;75:51–8.

Article  CAS  PubMed  Google Scholar 

Rakugi H, Yamakawa S, Sugimoto K. Management of hyperkalemia during treatment with mineralocorticoid receptor blockers: findings from esaxerenone. Hypertens Res. 2021;44:371–85.

Article  CAS  PubMed  Google Scholar 

Meneton P, Loffing J, Warnock DG. Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule. Am J Physiol Renal Physiol. 2004;287:F593–601.

Article  CAS  PubMed  Google Scholar 

Velázquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Ann Intern Med. 1993;119:296–301.

Article  PubMed  Google Scholar 

Antoniou T, Gomes T, Mamdani MM, Yao Z, Hellings C, Garg AX, Weir MA, Juurlink DN. Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study. Bmj. 2011;343:d5228.

Article  PubMed  PubMed Central  Google Scholar 

Antoniou T, Hollands S, Macdonald EM, Gomes T, Mamdani MM, Juurlink DN. Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone. Cmaj. 2015;187:E138–e143.

Article  PubMed  PubMed Central  Google Scholar 

Tezuka Y, Ito S. The Time to Reconsider Mineralocorticoid Receptor Blocking Strategy: Arrival of Nonsteroidal Mineralocorticoid Receptor Blockers. Curr Hypertens Rep. 2022;24:215–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirai T, Ueda S, Ogura T, Katayama K, Dohi K, Hosohata K, Aoyama T, Matsumoto Y, Iwamoto T. Hyperkalemia by eplerenone or esaxerenone in the presence or absence of clarithromycin in hypertensive patients: a retrospective observational cohort study. J Hypertens. 2023;41:580–6.

Article  CAS  PubMed  Google Scholar 

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982–92.

Article  CAS  PubMed  Google Scholar 

Tsapepas D, Chiles M, Babayev R, Rao MK, Jaitly M, Salerno D, Mohan S. Incidence of Hyponatremia with High-Dose Trimethoprim-Sulfamethoxazole Exposure. Am J Med. 2016;129:1322–8.

Article  CAS  PubMed  Google Scholar 

Chan WY, Clark AB, Wilson AM, Loke YK. The effect of co-trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial. Br J Clin Pharmacol. 2017;83:1808–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel RB, Welling PG. Clinical pharmacokinetics of co-trimoxazole (trimethoprim-sulphamethoxazole). Clin Pharmacokinet. 1980;5:405–23.

Article  CAS  PubMed  Google Scholar 

Vardeny O, Claggett B, Vaduganathan M, Beldhuis I, Rouleau J, O’Meara E, Anand IS, Shah SJ, Sweitzer NK, Fang JC, Desai AS, Lewis EF, Pitt B, Pfeffer MA, Solomon SD. Influence of Age on Efficacy and Safety of Spironolactone in Heart Failure. JACC Heart Fail. 2019;7:1022–8.

Article  PubMed  Google Scholar 

Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R. Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2020;97:42–61.

Article  CAS  PubMed  Google Scholar 

Montebello A, Gruppetta M. Cotrimoxazole-induced hyperkalaemia in a patient with known hypoaldosteronism. BMJ Case Rep. 2021;14:e239543.

Article  PubMed  PubMed Central  Google Scholar 

Elisaf M, Terrovitou C, Tomos P, Siamopoulos KC. Severe hyperkalaemia after cotrimoxazole administration in a patient with hyporeninaemic hypoaldosteronism. Nephrol Dial Transplant. 1997;12:1254–5.

Article  CAS  PubMed  Google Scholar 

Uchida HA, Nakajima H, Hashimoto M, Nakamura A, Nunoue T, Murakami K, Hosoya T, Komoto K, Taguchi T, Akasaka T, Shiosakai K, Sugimoto K, Wada J. Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetic Kidney Disease: A Multicenter, Open-Label. Prospective Study Adv Ther. 2022;39:5158–75.

CAS  PubMed  Google Scholar 

Ishikawa T, Morimoto S, Ichihara A. Effects of mineralocorticoid receptor antagonists on sex hormones and body composition in patients with primary aldosteronism. Hypertens Res. 2022;45:496–506.

Article  CAS  PubMed  Google Scholar 

Boddy K, King PC, Hume R, Weyers E. The relation of total body potassium to height, weight, and age in normal adults. J Clin Pathol. 1972;25:512–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirai T, Yamaga R, Fujita A, Itoh T. Low body mass index is a risk factor for hyperkalaemia associated with angiotensin converting enzyme inhibitors and angiotensin II receptor blockers treatments. J Clin Pharm Ther. 2018;43:829–35.

Article  CAS  PubMed  Google Scholar 

Dijkmans BA, van Hooff JP, de Wolff FA, Mattie H. The effect of co-trimoxazole on serum creatinine. Br J Clin Pharmacol. 1981;12:701–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roy MT, First MR, Myre SA, Cacini W. Effect of co-trimoxazole and sulfamethoxazole on serum creatinine in normal subjects. Ther Drug Monit. 1982;4:77–9.

Article  CAS  PubMed  Google Scholar 

Yamanaga S, Tanaka K, Kinoshita K, Kaba A, Fujii M, Ogata M, Hidaka Y, Kawabata C, Toyoda M, Uekihara S, Kashima M, Miyata A, Inadome A, Yokomizo H. Impact of Very Low-Dose Trimethoprim-Sulfamethoxazole on Serum Creatinine after Renal Transplantation: A Retrospective Study. Transplant Proc. 2020;52:1757–61.

Article  CAS  PubMed  Google Scholar 

Kastrup J, Petersen P, Bartram R, Hansen JM. The effect of trimethoprim on serum creatinine. Br J Urol. 1985;57:265–8.

Article  CAS  PubMed  Google Scholar 

Trollfors B, Wahl M, Alestig K. Co-trimoxazole, creatinine and renal function. J Infect. 1980;2:221–6.

Article  CAS  PubMed  Google Scholar 

Kainer G, Rosenberg AR. Effect of co-trimoxazole on the glomerular filtration rate of healthy adults. Chemotherapy. 1981;27:229–32.

Article  CAS  PubMed  Google Scholar 

Rafoth RJ, Onstad GR. Urea synthesis after oral protein ingestion in man. J Clin Invest. 1975;56:1170–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dossetor JB, Creatininemia versus uremia. The relative significance of blood urea nitrogen and serum creatinine concentrations in azotemia. Ann Intern Med. 1966;65:1287-1299

Sands JM. Mammalian urea transporters. Annu Rev Physiol. 2003;65:543–66.

Article  CAS  PubMed  Google Scholar 

Caulder CR, Kocherla CS, Qureshi ZP, Magagnoli J, Bookstaver PB.