An J-X, Wu G-P, Niu K, Wei Y-P, Liu H, Gao X-Y, et al. Treatment of femoral head osteonecrosis with ozone therapy: pilot trial of a new therapeutic approach. Pain Physician. 2022;25:E43–54.

PubMed  Google Scholar 

Hidalgo-Tallón FJ, Torres-Morera LM, Baeza-Noci J, Carrillo-Izquierdo MD, Pinto-Bonilla R. Updated review on ozone therapy in pain medicine. Front Physiol. 2022;13: 840623.

Article  PubMed  PubMed Central  Google Scholar 

de Sire A, Marotta N, Ferrillo M, Agostini F, Sconza C, Lippi L, et al. Oxygen–ozone therapy for reducing pro-inflammatory cytokines serum levels in musculoskeletal and temporomandibular disorders: a comprehensive review. Int J Mol Sci. 2022;23:2528.

Article  PubMed  PubMed Central  Google Scholar 

Bennett PM, Stewart SK, Dretzke J, Bem D, Penn-Barwell JG. Preclinical therapies to prevent or treat fracture non-union: a systematic review. PLoS ONE. 2018;13: e0201077.

Article  PubMed  PubMed Central  Google Scholar 

Kazancioglu HO, Ezirganli S, Aydin MS. Effects of laser and ozone therapies on bone healing in the calvarial defects. J Craniofac Surg. 2013;24:2141–6.

Article  PubMed  Google Scholar 

Irban A, Uslu S, Gereli A, Aydinlar EI, Karyemez PE, Luleci N, et al. The effect of ozone therapy on experimental bone fracture healing in rats [abstract]. J Ozone Ther. 2019;3:29.

Article  Google Scholar 

Feng X, Beiping L. Therapeutic efficacy of ozone injection into the knee for the osteoarthritis patient along with oral celecoxib and glucosamine. J Clin Diagn Res. 2017;11:UC01–3.

CAS  PubMed  PubMed Central  Google Scholar 

Sconza C, Respizzi S, Virelli L, Vandenbulcke F, Iacono F, Kon E, et al. Oxygen–ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthrosc J Arthrosc Relat Surg. 2020;36:277–86.

Article  Google Scholar 

Aliyev D, Akkemik U, Asik I. Efficacy of an intra-articular ozone injection for chronic knee pain due to osteoarthritis. Altern Ther Health Med. 2023;29:24–8.

PubMed  Google Scholar 

Lopes De Jesus CC, Dos Santos FC, De Jesus LMOB, Monteiro I, SantAna MSSC, Trevisani VFM. Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: a randomized, double-blinded, placebo-controlled study. PLoS ONE. 2017;12: e0179185.

Article  PubMed  PubMed Central  Google Scholar 

Biazzo A, Corriero AS, Confalonieri N. Intramuscular oxygen–ozone therapy in the treatment of low back pain. Acta Bio Medica Atenei Parmensis. 2018;89:41–6.

CAS  PubMed  PubMed Central  Google Scholar 

De Andrade RR, De Oliveira-Neto OB, Barbosa LT, Santos IO, De Sousa-Rodrigues CF, Barbosa FT. Effectiveness of ozone therapy compared to other therapies for low back pain: a systematic review with meta-analysis of randomized clinical trials. Braz J Anesthesiol. 2019;69:493–501 (English Edition).

Article  PubMed  PubMed Central  Google Scholar 

Nabi BN, Sedighinejad A, Mirbolouk AR, Farzi F, Haghighi M, Atrkarroushan Z, et al. The effectiveness of ozone therapy in chronic osteomyelitis: a randomized controlled clinical trial. Arch Clin Infect Dis. 2018;13: e61320.

Google Scholar 

Bilge A, Öztürk Ö, Adali Y, Üstebay S. Could ozone treatment be a promising alternative for osteomyelitis? An experimental study. Acta Ortop Bras. 2018;26:67–71.

Article  PubMed  PubMed Central  Google Scholar 

Viebahn-Hänsler R, León Fernández OS, Fahmy Z. Ozone in medicine: the low-dose ozone concept—guidelines and treatment strategies. Ozone Sci Eng. 2012;34:408–24.

Article  Google Scholar 

Yasheng T, Mijiti A, Yushan M, Liu Z, Liu Y, Yusufu A. Ozonated water lavage and physiological saline irrigation combined with vacuum-sealed drainage in the treatment of 18 cases of chronic osteomyelitis. J Int Med Res. 2021;49:0300060521999530.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rowen RJ, Robins H. Ozone therapy for complex regional pain syndrome: review and case report. Curr Pain Headache Rep. 2019;23:41.

Article  PubMed  PubMed Central  Google Scholar 

De Sire A, Agostini F, Lippi L, Mangone M, Marchese S, Cisari C, et al. Oxygen–ozone therapy in the rehabilitation field: state of the art on mechanisms of action, safety and effectiveness in patients with musculoskeletal disorders. Biomolecules. 2021;11:356.

Article  PubMed  PubMed Central  Google Scholar 

Alebouyeh M-R, Morsali SF, Zojaji F, Ebrahimi SA, Ahani A, Antar A. Refractory complex regional pain syndrome: a case report and review of literature. Anesth Pain Med. 2023;13: e135286.

Article  PubMed  PubMed Central  Google Scholar 

Seyam O, Smith N, Reid I, Gandhi J, Jiang W, Khan S. Clinical utility of ozone therapy for musculoskeletal disorders. Med Gas Res. 2018;8:103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bocci V. The potential toxicity of ozone: side effects and contraindications of ozonetherapy. In: Ozone. Dordrecht: Springer; 2010. p. 75–84.

Chapter  Google Scholar 

Xiao W, Tang H, Wu M, Liao Y, Li K, Li L, et al. Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway. Biosci Rep. 2017;37:BSR20170658.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pchepiorka R, Moreira MS, Lascane NADS, Catalani LH, Allegrini S Jr, De Lima NB, et al. Effect of ozone therapy on wound healing in the buccal mucosa of rats. Arch Oral Biol. 2020;119: 104889.

Article  CAS  PubMed  Google Scholar 

Fitzpatrick E, Holland OJ, Vanderlelie JJ. Ozone therapy for the treatment of chronic wounds: a systematic review. Int Wound J. 2018;15:633–44.

Article  PubMed  PubMed Central  Google Scholar 

Serra MEG, Baeza-Noci J, Mendes Abdala CV, Luvisotto MM, Bertol CD, Anzolin AP. The role of ozone treatment as integrative medicine. An evidence and gap map. Front Public Health. 2023;10:1112296.

Article  PubMed  PubMed Central  Google Scholar 

Akkawi I. Ozone therapy for musculoskeletal disorders Current concepts. Acta Biomed. 2020;91(4):e2020191.

Bocci V. How is ozone administered? Ozone. 2010. https://doi.org/10.1007/978-90-481-9234-2_5.

Article  PubMed Central  Google Scholar 

Re L, Mawsouf MN, Menéndez S, León OS, Sánchez GM, Hernández F. Ozone therapy: clinical and basic evidence of its therapeutic potential. Arch Med Res. 2008;39:17–26.

Article  CAS  PubMed  Google Scholar 

Bocci VA. Tropospheric ozone toxicity vs. usefulness of ozone therapy. Arch Med Res. 2007;38:265–7.

Article  CAS  PubMed  Google Scholar 

Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediat Inflamm. 2004;13:3–11.

Article  CAS  Google Scholar 

Li Q, Qi X, Zhang Z. Intra-articular oxygen–ozone versus hyaluronic acid in knee osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2018;58:3–10.

Article  PubMed  Google Scholar 

Sagai M, Bocci V. Mechanisms of action involved in ozone therapy: is healing induced via a mild oxidative stress? Med Gas Res. 2011;1:29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández-Cuadros ME, Pérez-Moro OS, Albaladejo-Florín MJ, Tobar-Izquierdo MM, Magaña-Sánchez A, Jiménez-Cuevas P, et al. Intra articular ozone modulates inflammation and has anabolic effect on knee osteoarthritis: IL-6 and IGF-1 as pro-inflammatory and anabolic biomarkers. Processes. 2022;10:138.

Article  Google Scholar 

Travagli V, Iorio EL. The biological and molecular action of ozone and its derivatives: state-of-the-art, enhanced scenarios, and quality insights. Int J Mol Sci. 2023;24:8465.

Article  CAS