Almubarak A, Tanagala KKK, Papapanou PN, Lalla E, Momen-Heravi F. Disruption of monocyte and macrophage homeostasis in periodontitis. Front Immunol. 2020;26(11):330.

Article  Google Scholar 

Mummolo S, Botticelli G, Quinzi V, Giuca G, Mancini L, Marzo G. Implant-safe test in patients with peri-implantitis. J Biol Regul Homeost Agents. 2020 May-Jun; 34 3 Suppl. 1:147–153.

Kim AR, Bak EJ, Yoo YJ. Distribution of neutrophil and monocyte/macrophage populations induced by the CXCR4 inhibitor AMD3100 in blood and periodontal tissue early after periodontitis induction. J Periodontal Res. 2022;57(2):332–40.

Article  CAS  PubMed  Google Scholar 

Chen Y, Liu Y, Xia H, Xia G, Xu J, Lin S, Guo L, Liu Y. The effect of the Litcubanine A on the treatment of murine experimental periodontitis by inhibiting monocyte-macrophage chemotaxis and osteoclast differentiation. J Periodontal Res. 2023;58(5):948–58.

Article  CAS  PubMed  Google Scholar 

Du Y, Liu X, Xiao C, Li J, Sheng Z, Wang Y, Wang R, Yu X. TIPE2 regulates periodontal inflammation by inhibiting NF-κB p65 phosphorylation. J Appl Oral Sci. 2023;24(31): e20230162.

Article  Google Scholar 

Cavalla F, Hernández M. Polarization profiles of t lymphocytes and macrophages responses in periodontitis. Adv Exp Med Biol. 2022;1373:195–208.

Article  CAS  PubMed  Google Scholar 

Li J, Sheng Z, Sun J, Wang R, Yu X. Characterizations of alveolar repair after mandibular second molar extraction: an experimental study in rats. J Appl Oral Sci. 2022;30: e20220010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu Y, Hao X, Shang P, Chamba Y, Zhang B, Zhang H. Functional Identification of Porcine DLK1 during Muscle Development. Animals (Basel). 2022 Jun 11;12(12):1523.9 Vietor I, Cikes D, Piironen K, Vasakou T, Heimdörfer D, Gstir R, Erlacher MD, Tancevski I, Eller P, Demetz E, Hess MW, Kuhn V, Degenhart G, Rozman J, Klingenspor M, Hrabe de Angelis M, Valovka T, Huber LA. The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). Elife. 2023 Aug 21;12:e88350.

Jensen CH, Kosmina R, Rydén M, Baun C, Hvidsten S, Andersen MS, Christensen LL, Gastaldelli A, Marraccini P, Arner P, Jørgensen CD, Laborda J, Holst JJ, Andersen DC. The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake. EBioMedicine. 2019;46:368–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pittaway JFH, Lipsos C, Mariniello K, Guasti L. The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer. Endocr Relat Cancer. 2021;28(12):R271–87.

Article  CAS  PubMed  Google Scholar 

Perramón M, Jiménez W. Pituitary tumor-transforming gene 1/delta like non-canonical notch ligand 1 signaling in chronic liver diseases. Int J Mol Sci. 2022;23(13):6897.

Article  PubMed  PubMed Central  Google Scholar 

Lee CC, Lin CL, Leu SJ, Lee YL. Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice. Clin Immunol. 2018;187:58–67.

Article  CAS  PubMed  Google Scholar 

Marquez-Exposito L, Rodrigues-Diez RR, Rayego-Mateos S, Fierro-Fernandez M, Rodrigues-Diez R, Orejudo M, Santos-Sanchez L, Blanco EM, Laborda J, Mezzano S, Lamas S, Lavoz C, Ruiz-Ortega M. Deletion of delta-like 1 homologue accelerates renal inflammation by modulating the Th17 immune response. FASEB J. 2021;35(1): e21213.

Article  CAS  PubMed  Google Scholar 

González MJ, Ruiz-García A, Monsalve EM, Sánchez-Prieto R, Laborda J, Díaz-Guerra MJ, Ruiz-Hidalgo MJ. DLK1 is a novel inflammatory inhibitor which interferes with NOTCH1 signaling in TLR-activated murine macrophages. Eur J Immunol. 2015;45(9):2615–27.

Article  PubMed  Google Scholar 

Zeng N, Jian Z, Xu J, Zheng S, Fan Y, Xiao F. DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs. J Mol Histol. 2023;54(6):655–64.

Article  CAS  PubMed  Google Scholar 

Liu CL, Ho TL, Fang SY, Guo JH, Wu CY, Fong YC, Liaw CC, Tang CH. Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways. Biomed Pharmacother. 2023;166: 115392.

Article  CAS  PubMed  Google Scholar 

Yi X, Song Y, Xu J, Wang L, Liu L, Huang D, Zhang L. NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells. Odontology. 2024;112(1):100–11.

Article  CAS  PubMed  Google Scholar 

Heo YJ, Lee N, Choi SE, Jeon JY, Han SJ, Kim DJ, Kang Y, Lee KW, Kim HJ. Amphiregulin Induces iNOS and COX-2 expression through NF-κB and MAPK signaling in hepatic inflammation. Mediators Inflamm. 2023;11(2023):2364121.

Google Scholar 

Omata Y, Tachibana H, Aizaki Y, Mimura T, Sato K. Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation. Sci Rep. 2023;13(1):18797.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D’Aiuto F, Bouchard P, Chapple I, Dietrich T, Gotsman I, Graziani F, Herrera D, Loos B, Madianos P, Michel JB, Perel P, Pieske B, Shapira L, Shechter M, Tonetti M, Vlachopoulos C, Wimmer G. Periodontitis and cardiovascular diseases: Consensus report. J Clin Periodontol. 2020;47(3):268–88.

Article  PubMed  PubMed Central  Google Scholar 

Yu B, Wang CY. Osteoporosis and periodontal diseases–an update on their association and mechanistic links. Periodontol. 2022. https://doi.org/10.1111/prd.12422.

Article  Google Scholar 

Fischer RG, Lira Junior R, Retamal-Valdes B, Figueiredo LC, Malheiros Z, Stewart B, Feres M. Periodontal disease and its impact on general health in Latin America Section V: treatment of periodontitis. Braz Oral Res. 2020. https://doi.org/10.1590/1807-3107bor-2020.vol34.0026.

Article  PubMed  Google Scholar 

Darby I. Risk factors for periodontitis & peri-implantitis. Periodontol. 2022. https://doi.org/10.1111/prd.12447.

Article  Google Scholar 

Jensen CH, Johnsen RH, Eskildsen T, Baun C, Ellman DG, Fang S, Bak ST, Hvidsten S, Larsen LA, Rosager AM, Riber LP, Schneider M, De Mey J, Thomassen M, Burton M, Uchida S, Laborda J, Andersen DC. Pericardial delta like non-canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition. Clin Transl Med. 2024;14(2): e1565.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Demir Çaltekin M, Caniklioğlu A, Eris Yalçın S, Aydoğan Kırmızı D, Baser E, Yalvaç ES. DLK1 and Nesfatin-1 levels and the relationship with metabolic parameters in polycystic ovary syndrome: prospective, controlled study. Turk J Obstet Gynecol. 2021;18(2):124–30.

Article  PubMed  PubMed Central  Google Scholar 

Molina-Pinelo S, Salinas A, Moreno-Mata N, Ferrer I, Suarez R, Andrés-León E, Rodríguez-Paredes M, Gutekunst J, Jantus-Lewintre E, Camps C, Carnero A, Paz-Ares L. Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer. Oncotarget. 2016;9(4):4395–410.

Article  PubMed  PubMed Central  Google Scholar 

Udagawa N, Koide M, Nakamura M, Nakamichi Y, Yamashita T, Uehara S, Kobayashi Y, Furuya Y, Yasuda H, Fukuda C, Tsuda E. Osteoclast differentiation by RANKL and OPG signaling pathways. J Bone Miner Metab. 2021;39(1):19–26.

Article  CAS  PubMed  Google Scholar 

Elson A, Anuj A, Barnea-Zohar M, Reuven N. The origins and formation of bone-resorbing osteoclasts. Bone. 2022;164: 116538.

Article  CAS  PubMed  Google Scholar 

Wang RP, Huang J, Chan KWY, Leung WK, Goto T, Ho YS, Chang RC. IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease. J Neuroinflammation. 2023;20(1):71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aleksandrowicz P, Brzezińska-Błaszczyk E, Kozłowska E, Żelechowska P, Borgonovo AE, Agier J. Analysis of IL-1β, CXCL8, and TNF-α levels in the crevicular fluid of patients with periodontitis or healthy implants. BMC Oral Health. 2021;21(1):120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang H, Jing B, Zhu F, Jiang W, Tang P, Shi L, Chen H, Ren G, Xia S, Wang L, Cui Y, Yang Z, Platero AJ, Hutchins AP, Chen M, Worley PF, Xiao B. Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis. Cell Rep. 2023;42(7): 112801.

Article  CAS  PubMed