Altenburg J, de Graaff CS, van der Werf TS et al (2011) Immunomodulatory Effects of Macrolide Antibiotics - Part 2: Advantages and Disadvantages of Long-Term. Low-Dose Macrolide Ther Respi 81(1):75–87. https://doi.org/10.1159/000320320

Article  CAS  Google Scholar 

Andreu JM, Huecas S, Araujo-Bazan L et al (2022) The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites. Biomed 10(8). https://doi.org/10.3390/biomedicines10081825

Barrows JM, Goley ED (2021) FtsZ dynamics in bacterial division: What, how, and why? Curr Opin Cell Biol 68:163–172. https://doi.org/10.1016/j.ceb.2020.10.013

Article  CAS  PubMed  Google Scholar 

Belluomini L, Caldart A, Avancini A et al. (2021) Infections and Immunotherapy in Lung Cancer: A Bad Relationship? Int J Mol Sci 22(1). https://doi.org/10.3390/ijms22010042

Berthold MR, Cebron N, Dill F et al (2008) KNIME: the Konstanz information miner 319–326. https://doi.org/10.1007/978-3-540-78246-9_38

Bhattacharya B, Mukherjee S (2015) Cancer Therapy Using Antibiotics. J Cancer Ther 06(10):849–858. https://doi.org/10.4236/jct.2015.610093

Article  CAS  Google Scholar 

Casiraghi A, Suigo L, Valoti E et al (2020) Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics-Basel 9(2). https://doi.org/10.3390/antibiotics9020069

Cordell SC, Robinson EJH, Löwe J (2003) Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ 100(13):7889–7894. https://doi.org/10.1073/pnas.1330742100

Article  CAS  Google Scholar 

Czaplewski LG, Collins I, Boyd EA et al (2009) Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorg Med Chem Lett 19(2):524–527. https://doi.org/10.1016/j.bmcl.2008.11.021

Article  CAS  PubMed  Google Scholar 

Dias FRF, Novais JS, Devillart TA et al (2018) Synthesis and antimicrobial evaluation of amino sugar-based naphthoquinones and isoquinoline-5,8-diones and their halogenated compounds. Eur J Med Chem 156:1–12. https://doi.org/10.1016/j.ejmech.2018.06.050

Article  CAS  PubMed  Google Scholar 

Domadia P, Swarup S, Bhunia A et al (2007) Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde. Biochem Pharmacol 74(6):831–840. https://doi.org/10.1016/j.bcp.2007.06.029

Article  CAS  PubMed  Google Scholar 

Ferrer-Gonzalez E, Kaul M, Parhi AK et al (2017) beta-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus, Antimicrobial Agents and Chemotherapy 61(9). https://doi.org/10.1128/aac.00863-17

Gadde U, Kim WH, Oh ST et al (2017) Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review. Anim Health Res Rev 18(1):26–45. https://doi.org/10.1017/s1466252316000207

Article  CAS  PubMed  Google Scholar 

Haydon DJ, Stokes NR, Ure R et al (2008) An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science 321(5896):1673–1675. https://doi.org/10.1126/science.1159961

Article  CAS  PubMed  Google Scholar 

Huang XH, Sun N, Zhong DX et al (2020) A Review on Bacterial Cell division Protein and Recent Progress of FtsZ Inhibitors Development. Prog Biochem Biophys 47(9):935–955. https://doi.org/10.16476/j.pibb.2020.0055

Article  CAS  Google Scholar 

Jaiswal R, Beuria TK, Mohan R et al (2007) Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ. Biochemistry 46(14):4211–4220. https://doi.org/10.1021/bi602573e

Article  CAS  PubMed  Google Scholar 

Kate M, Mark L, Zhang YZ et al (2015) TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother 59(8):4845–4855. https://doi.org/10.1128/aac.00708-15

Article  Google Scholar 

Keffer JL, Huecas S, Hammill JT et al (2013) Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria 21(18):5673–5678. https://doi.org/10.1016/j.bmc.2013.07.033

Article  CAS  Google Scholar 

Kim MB, Shaw JT (2010) Synthesis of Antimicrobial Natural Products Targeting FtsZ: (+)-Totarol and Related Totarane Diterpenes. Org Lett 12(15):3324–3327. https://doi.org/10.1021/ol100929z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar SB, Arnipalli SR, Ziouzenkova O (2020) Antibiotics in Food Chain: The Consequences for Antibiotic Resistance. Antibiotics-Basel 9(10). https://doi.org/10.3390/antibiotics9100688

Li Y, Sun N, Ser H-L et al (2020) Antibacterial activity evaluation and mode of action study of novel thiazole-quinolinium derivatives. RSC Adv 10(25):15000–15014. https://doi.org/10.1039/D0RA00691B

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Wu Y, Gao Y et al (2022) Machine-learning based prediction of prognostic risk factors in patients with invasive candidiasis infection and bacterial bloodstream infection: a singled centered retrospective study. Bmc Infect Dis 22(1). https://doi.org/10.1186/s12879-022-07125-8

Liao Y, Ithurbide S, Evenhuis C et al (2021) Cell division in the archaeon Haloferax volcanii relies on two FtsZ proteins with distinct functions in division ring assembly and constriction. Nat Microbiol 6(5):594. https://doi.org/10.1038/s41564-021-00894-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu N, Xu Z (2019) Using LeDock as a docking tool for computational drug design. IOP Conference Series: Earth and Environmental Science 218(1):012143. https://doi.org/10.1088/1755-1315/218/1/012143

Article  Google Scholar 

Matsui T, Yamane J, Mogi N et al (2012) Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus. Acta Crystallographica Section D-Structural Biology 68:1175–1188. https://doi.org/10.1107/s0907444912022640

Article  CAS  Google Scholar 

Matsui T, Han X, Yu J et al (2014) Structural Change in FtsZ Induced by Intermolecular Interactions between Bound GTP and the T7 Loop *. J Biol Chem 289(6):3501–3509. https://doi.org/10.1074/jbc.M113.514901

Article  CAS  PubMed  Google Scholar 

Milani G, Cavalluzzi MM, Solidoro R et al (2021) Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models. Biomed 9(5). https://doi.org/10.3390/biomedicines9050452

Murray CJL, Ikuta KS, Sharara F et al (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399(10325):629–655. https://doi.org/10.1016/s0140-6736(21)02724-0

Article  CAS  Google Scholar 

Mysinger MM, Carchia M, Irwin JJ et al (2012) Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking. J Med Chem 55(14):6582–6594. https://doi.org/10.1021/jm300687e

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandolfi F, Guillemot D, Watier L et al (2022) Trends in bacterial sepsis incidence and mortality in France between 2015 and 2019 based on National Health Data System (Systeme National des donnees de Sante (SNDS)): a retrospective observational study. Bmj Open 12(5). https://doi.org/10.1136/bmjopen-2021-058205

Prasad HSN, Ananda AP, Sumathi S et al (2022) Piperazine selenium nanoparticle (Pipe@SeNP’s): A futuristic anticancer contender against MDA-MB-231 cancer cell line. J Mol Struct 1268:133683. https://doi.org/10.1016/j.molstruc.2022.133683

Article  CAS  Google Scholar 

Qin Y, Qiang S, Ji S et al (2018) Synthesis and antibacterial activity of novel 3-O-arylalkylcarbamoyl-3-O-descladinosyl-9-O-(2-chlorobenzyl)oxime clarithromycin derivatives. Bioorg Med Chem Lett 28(20):3324–3328. https://doi.org/10.1016/j.bmcl.2018.09.012

Article  CAS  PubMed  Google Scholar 

Repasky MP, Murphy RB, Banks JL et al (2012) Docking performance of the glide program as evaluated on the Astex and DUD datasets: a complete set of glide SP results and selected results for a new scoring function integrating WaterMap and glide. J Comput Aided Mol Des 26(6):787–799. https://doi.org/10.1007/s10822-012-9575-9

Article  CAS  PubMed  Google Scholar 

Song D, Zhang N, Zhang P et al (2021) Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. Eur J Med Chem 221:113480. https://doi.org/10.1016/j.ejmech.2021.113480

Article  CAS  PubMed  Google Scholar 

Sun N, Chan F-Y, Lu Y-J et al (2014) Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity. PLoS ONE 9(5):e97514. https://doi.org/10.1371/journal.pone.0097514

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Zhang BL,Luo LX et al (2023) Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy (129, 106157, 2022) Bioorg Chem 131. https://doi.org/10.1016/j.bioorg.2022.106336