Molecular mechanism of geniposide against ANIT-induced intrahepatic cholestasis by integrative analysis of transcriptomics and metabolomics

Boyer JL (2013) Bile Formation and Secretion. Compr Physiol 3(3):1035–1078. https://doi.org/10.1002/cphy.c120027

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V (2013) Glutathione defense mechanism in liver injury: insights from animal models. Food Chem Toxicol 60:38–44. https://doi.org/10.1016/j.fct.2013.07.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiang JY (2013) Bile acid metabolism and signaling. Compr Physiol 3(3):1191–1212. https://doi.org/10.1002/cphy.c120023

Article  PubMed  PubMed Central  Google Scholar 

Copple BL, Jaeschke H, Klaassen CD (2010) Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis 30(2):195–204. https://doi.org/10.1055/s-0030-1253228

Article  CAS  PubMed  Google Scholar 

Corpechot C, Chazouillères O, Poupon R (2011) Early primary biliary cirrhosis: biochemical response to treatment and prediction of long-term outcome. J Hepatol 55(6):1361–1367. https://doi.org/10.1016/j.jhep.2011.02.031

Article  CAS  PubMed  Google Scholar 

Fang S, Wang T, Li Y, Xue H, Zou J, Cai J et al (2022) Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway. Int J Biol Macromol 205:23–36. https://doi.org/10.1016/j.ijbiomac.2022.02.056

Article  CAS  PubMed  Google Scholar 

Gao S, Feng Q (2022) The beneficial effects of geniposide on glucose and lipid metabolism: a review. Drug Des Devel Ther 16:3365–3383. https://doi.org/10.2147/DDDT.S378976

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Q, Li G, Zu Y, Xu Y, Wang C, Xiang D et al (2024) Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation. J Ethnopharmacol 319(Pt 1):117089. https://doi.org/10.1016/j.jep.2023.117089

Article  CAS  PubMed  Google Scholar 

Garcia-Ruiz C, Fernandez-Checa JC (2006) Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol 21(Suppl 3):S3–S6. https://doi.org/10.1111/j.1440-1746.2006.04570.x

Article  CAS  PubMed  Google Scholar 

Graf GA, Yu L, Li WP, Gerard R, Tuma PL, Cohen JC et al (2003) ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem 278(48):48275–48282. https://doi.org/10.1074/jbc.M310223200

Article  CAS  PubMed  Google Scholar 

Hassan S, Hertel P (2022) Overview of progressive familial intrahepatic cholestasis. Clin Liver Dis 26(3):371–390. https://doi.org/10.1016/j.cld.2022.03.003

Article  PubMed  Google Scholar 

Hassan MA, Al-Sakkaf K, Shait Mohammed MR, Dallol A, Al-Maghrabi J, Aldahlawi A et al (2020) Integration of transcriptome and metabolome provides unique insights to pathways associated with obese breast cancer patients. Front Oncol 10:804. https://doi.org/10.3389/fonc.2020.00804

Article  PubMed  PubMed Central  Google Scholar 

Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon SC, Mayo M et al (2015) Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology 148(4):751–61.e8. https://doi.org/10.1053/j.gastro.2014.12.005

Article  CAS  PubMed  Google Scholar 

Hobson S, Gandhi S, Sobel M (2022) Intrahepatic cholestasis of pregnancy. CMAJ 194(48):E1650. https://doi.org/10.1503/cmaj.220334

Article  PubMed  PubMed Central  Google Scholar 

Hu L, Zhao J, Liu Y, Liu X, Lu Q, Zeng Z et al (2020) Geniposide inhibits proliferation and induces apoptosis of diffuse large B-cell lymphoma cells by inactivating the HCP5/miR-27b-3p/MET axis. Int J Med Sci 17(17):2735–2743. https://doi.org/10.7150/ijms.51329

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ivashkin VT, Maevskaya MV, Kobalava ZD, Uspenskiy YP, Fominih JA, Rozanov AV et al (2018) Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease. Minerva Gastroenterol Dietol 64(3):208–219. https://doi.org/10.23736/S1121-421X.18.02461-3

Article  PubMed  Google Scholar 

Jin Z, Chang B, Wei Y, Yang Y, Zhang H, Liu J et al (2022) Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy. Biomed Pharmacother 151:113092. https://doi.org/10.1016/j.biopha.2022.113092

Article  CAS  PubMed  Google Scholar 

Johnston RA, Rawling T, Chan T, Zhou F, Murray M (2014) Selective inhibition of human solute carrier transporters by multikinase inhibitors. Drug Metab Dispos 42(11):1851–1857. https://doi.org/10.1124/dmd.114.059097

Article  CAS  PubMed  Google Scholar 

Kim HY (2021) Recent advances in nonalcoholic fatty liver disease metabolomics. Clin Mol Hepatol 27(4):553–559. https://doi.org/10.3350/cmh.2021.0127

Article  PubMed  PubMed Central  Google Scholar 

Kowdley KV, Luketic V, Chapman R, Hirschfield GM, Poupon R, Schramm C et al (2018) A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis. Hepatology 67(5):1890–1902. https://doi.org/10.1002/hep.29569

Article  CAS  PubMed  Google Scholar 

Kumar A, Dhull DK, Gupta V, Channana P, Singh A, Bhardwaj M et al (2017) Role of glutathione-S-transferases in neurological problems. Expert Opin Ther Pat 27(3):299–309. https://doi.org/10.1080/13543776.2017.1254192

Article  CAS  PubMed  Google Scholar 

Levy C, Manns M, Hirschfield G (2023) New treatment paradigms in primary biliary cholangitis. Clin Gastroenterol Hepatol 21(8):2076–2087. https://doi.org/10.1016/j.cgh.2023.02.005

Article  CAS  PubMed  Google Scholar 

Liu J, Liu J, Meng C, Huang C, Liu F, Xia C (2022a) Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis. Phytomedicine 102:154173. https://doi.org/10.1016/j.phymed.2022.154173

Article  CAS  PubMed  Google Scholar 

Liu J, Song C, Nie C, Sun Y, Wang Y, Xue L et al (2022b) A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4. Phytomedicine 95:153862. https://doi.org/10.1016/j.phymed.2021.153862

Article  CAS  PubMed  Google Scholar 

Lixin X, Erli G, Songping H, Yonggen Z, Wang J, Lijun Y (2019) Yi Guan Jian, A traditional chinese herbal medicine, alleviates carbon tetrachloride-induced liver injury. Evid Based Complement Alternat Med 2019:9824728. https://doi.org/10.1155/2019/9824728

Article  PubMed  PubMed Central  Google Scholar 

Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW et al (2019) Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature 569(7758):655–662. https://doi.org/10.1038/s41586-019-1237-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu SC (2009) Regulation of glutathione synthesis. Mol Aspects Med 30(1–2):42–59. https://doi.org/10.1016/j.mam.2008.05.005

Article  CAS  PubMed  Google Scholar 

Menyhárt O, Győrffy B (2021) Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis. Comput Struct Biotechnol J 19:949–960.

留言 (0)

沒有登入
gif