Alves CL, Ditzel HJ (2023) Drugging the PI3K/AKT/mTOR pathway in ER+ breast cancer. Int J Mol Sci 24(5):4522. https://doi.org/10.3390/ijms24054522

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao MH, Zhang YW, Zhou HH (2013) Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-κB pathway. J Ethnopharmacol 146(2):543–551. https://doi.org/10.1016/j.jep.2013.01.019

Article  CAS  PubMed  Google Scholar 

Chen B, Zhang L, Zhou H, Ye W, Luo C, Yang L et al (2022) HMOX1 promotes lung adenocarcinoma metastasis by affecting macrophages and mitochondrion complexes. Front Oncol 12:978006. https://doi.org/10.3389/fonc.2022.978006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choy KW, Lau YS, Murugan D, Vanhoutte PM, Mustafa MR (2018) Paeonol attenuates LPS-induced endothelial dysfunction and apoptosis by inhibiting BMP4 and TLR4 signaling simultaneously but independently. J Pharmacol Exp Ther 364(3):420–432. https://doi.org/10.1124/jpet.117.245217

Article  CAS  PubMed  Google Scholar 

Dong R, Li J, Jiang G, Han N, Zhang Y, Shi X (2023) Novel immune cell infiltration-related biomarkers in atherosclerosis diagnosis. PeerJ 11:e15341. https://doi.org/10.7717/peerj.15341

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan J, Watanabe T (2022) Atherosclerosis: known and unknown. Pathol Int 72(3):151–160. https://doi.org/10.1111/pin.13202

Article  PubMed  Google Scholar 

He X, Li Y, Deng B, Lin A, Zhang G, Ma M et al (2022) The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: mechanisms and therapeutic opportunities. Cell Prolif 55(9):e13275. https://doi.org/10.1111/cpr.13275

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huo X, Su B, Qin G, Zhao L (2022) HMGB1 promotes Ox-LDL-induced endothelial cell damage by inhibiting PI3K/Akt signaling pathway. BMC Cardiovasc Disord 22(1):555. https://doi.org/10.1186/s12872-022-03003-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Stockwell BR (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266–282. https://doi.org/10.1038/s41580-020-00324-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin ZL, Gao WY, Liao SJ, Yu T, Shi Q, Yu SZ et al (2021) Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis. ASN Neuro 13:17590914211010648. https://doi.org/10.1177/17590914211010647

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132(1):27–42. https://doi.org/10.1016/j.cell.2007.12.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Li Y, Zhao Y, Ren L (2020) The protective effects of aloperine against ox-LDL-induced endothelial dysfunction and inflammation in HUVECs. Artif Cells Nanomed Biotechnol 48(1):107–115. https://doi.org/10.1080/21691401.2019.1699816

Article  CAS  PubMed  Google Scholar 

Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82(12):2215–2227. https://doi.org/10.1016/j.molcel.2022.03.022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu YR, Chen JJ, Dai M (2014) Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release. Acta Pharmacol Sin 35(4):483–488. https://doi.org/10.1038/aps.2013.190

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Li C, Wu H, Xie X, Sun Y, Dai M (2018) Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal microRNA-223. Front Pharmacol 9:1105. https://doi.org/10.3389/fphar.2018.01105

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Han Y, Gu X, Li M, Du Y, Feng N et al (2021a) Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy. Redox Biol 46:102098. https://doi.org/10.1016/j.redox.2021.102098

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Song A, Wu H, Sun Y, Dai M (2021b) Paeonol inhibits apoptosis of vascular smooth muscle cells via up-regulation of autophagy by activating class III PI3K/Beclin-1 signaling pathway. Life Sci 264:118714. https://doi.org/10.1016/j.lfs.2020.118714

Article  CAS  PubMed  Google Scholar 

Liu C, Yi X, Yan J, Liu Q, Cao T, Liu S (2023a) Paeonol improves angiotensin II-induced cardiac hypertrophy by suppressing ferroptosis. Heliyon 9(9):e19149. https://doi.org/10.1016/j.heliyon.2023.e19149

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Cao X, Zhang T, Zhang C, Qu J, Sun Y et al (2023b) Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. Phytomedicine 109:154593. https://doi.org/10.1016/j.phymed.2022.154593

Article  CAS  PubMed  Google Scholar 

Long HZ, Cheng Y, Zhou ZW, Luo HY, Wen DD, Gao LC (2021) PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer’s disease and Parkinson’s disease. Front Pharmacol 12:648636. https://doi.org/10.3389/fphar.2021.648636

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu L, Qin Y (2018) Beneficial effects exerted by paeonol in the management of atherosclerosis. Oxid Med Cell Longev 2018:1098617. https://doi.org/10.1155/2018/1098617

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng Z, Liang H, Zhao J, Gao J, Liu C, Ma X et al (2021) HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis. Life Sci 284:119935. https://doi.org/10.1016/j.lfs.2021.119935

Article  CAS  PubMed  Google Scholar 

Navaei ZN, Khalili-Tanha G, Zangouei AS, Abbaszadegan MR, Moghbeli M (2021) PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells. Oncol Res 29(4):235–250. https://doi.org/10.32604/or.2022.025323

Article  PubMed  Google Scholar 

Qian J, Wan W, Fan M (2023) HMOX1 silencing prevents doxorubicin-induced cardiomyocyte injury, mitochondrial dysfunction, and ferroptosis by downregulating CTGF. Gen Thorac Cardiovasc Surg 71(5):280–290. https://doi.org/10.1007/s11748-022-01867-7

Article  PubMed  Google Scholar 

Shang P, Liu Y, Jia J (2022) Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1. Can J Physiol Pharmacol 100(4):283–290. https://doi.org/10.1139/cjpp-2021-0319

Article  CAS  PubMed  Google Scholar 

Sun L, Wang H, Xu D, Yu S, Zhang L, Li X (2022) Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/AKT signaling pathway. Bioengineered 13(1):48–60. https://doi.org/10.1080/21655979.2021.2004980

Article  CAS  PubMed