Interrogating erectile dysfunction and evaluating novel therapeutic frontiers, with emphasis on stem cell strategies

Goldstein I, Goren A, Li VW, Tang WY, Hassan TA. Epidemiology update of erectile dysfunction in eight countries with high burden. Sex Med Rev. 2020 [cited 2024 Apr 10];8:48–58. Available from: https://pubmed.ncbi.nlm.nih.gov/31416758/.

Khan S, Kulkarni V, Shah R, Gokral J, Meherji P, Vadigoppula A, et al. Clinical presentations and semen characteristics of men attending the secondary referral infertility clinic at Mumbai, India. J Hum Reprod Sci. 2021;14:356–64.

Article  PubMed  PubMed Central  Google Scholar 

Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A. Some of the factors involved in male infertility: a prospective review. Int J Gen Med. 2020 [cited 2022 Dec 15];13:29. Available from: /pmc/articles/PMC7008178/. Accessed 14 Dec 2023

Dyer SJ. International estimates on infertility prevalence and treatment seeking: potential need and demand for medical care. Human Reproduction. 2009 [cited 2022 Dec 15];24:2379–80. Available from: https://academic.oup.com/humrep/article/24/9/2379/602143.

Brugo-Olmedo S, Chillik C, Kopelman S. Definition and causes of infertility. Reprod Biomed Online. 2001 [cited 2022 Dec 15];2:41–53. Available from: https://pubmed.ncbi.nlm.nih.gov/12537824/.

Borumandnia N, Majd HA, Khadembashi N, Alaii H. Worldwide trend analysis of primary and secondary infertility rates over past decades: a cross-sectional study. Int J Reprod Biomed. 2022;20:37–46.

Article  PubMed  PubMed Central  Google Scholar 

Fertility rate, total (births per woman), The World Bank data. The World Bank. 2023 [cited 2023 Mar 23]. Available from: https://data.worldbank.org/indicator/SP.DYN.TFRT.IN?contextual=default&end=2020&locations=1W-IN-US-AU&name_desc=false&start=1960&view=chart.

State-wise total fertility rate, Publications. Reserve Bank of India. 2022 [cited 2023 Mar 23]. Available from: https://m.rbi.org.in/scripts/PublicationsView.aspx?id=21403.

Pakpahan C, Ibrahim R, William W, Faizah Z, Juniastuti J, Lusida MI, et al. Stem cell therapy and diabetic erectile dysfunction: a critical review. World J Stem Cells. 2021;13:1549–63.

Article  PubMed  PubMed Central  Google Scholar 

Siregar S, Novesar AR, Mustafa A. Application of stem cell in human erectile dysfunction – a systematic review. Res Rep Urol. 2022;14:379–88.

PubMed  PubMed Central  Google Scholar 

Rosen RC, Cappelleri JC, Gendrano N. The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res. 2002 [cited 2022 Dec 16];14:226–44. Available from: https://pubmed.ncbi.nlm.nih.gov/12152111/

Matsui H, Sopko NA, Hannan JL, Bivalacqua TJ. Pathophysiology of erectile dysfunction. Curr Drug Targets. 2015 [cited 2022 Dec 16];16:411–9. Available from: https://jhu.pure.elsevier.com/en/publications/pathophysiology-of-erectile-dysfunction-3

Retzler K. Erectile dysfunction: a review of comprehensive treatment options for optimal outcome. J Restor Med. 2019 [cited 2022 Dec 16];8. Available from: https://restorativemedicine.org/journal/erectile-dysfunction-review-comprehensive-treatment-options-optimal-outcome.

Retzler K. Erectile dysfunction: a review of comprehensive treatment options for optimal outcome. J Restor Med. 2019;8:(1):e20190104.

Elbashir S, Magdi Y, Rashed A, Henkel R, Agarwal A. Epididymal contribution to male infertility: an overlooked problem. Andrologia. 2021 [cited 2022 Dec 15];53. Available from: https://pubmed.ncbi.nlm.nih.gov/32816323/.

Deng N, Thirumavalavan N, Beilan JA, Tatem AJ, Hockenberry MS, Pastuszak AW, et al. Sexual dysfunction and infertility in the male spina bifida patient. TranslAndrolUrol. 2018 [cited 2022 Dec 15];7:941–9. Available from: https://pubmed.ncbi.nlm.nih.gov/30505732/

GhadigaonkarDS, Murthy P. Sexual dysfunction in persons with substance use disorders. [Internet]. 2019 [cited 2022 Dec15];1:117–21. Available from: https://journals.sagepub.com/doi/full/10.1177/2631831819849365.

Río FJ del, Cabello F, Fernández I. Influence of substance use on the erectile response in a sample of drug users. Int J Clin Health Psychol. 2015 [cited 2022 Dec 15];15:37. Available from: /pmc/articles/PMC6224805/. Accessed 14 Dec 2023.

Ghadigaonkar DS, Murthy P. Sexual dysfunction in persons with substance use disorders. J Psychosexual Health. 2019 [cited 2023 Jun 23];1:117–21. Available from: https://us.sagepub.com/en-us/nam/open-access-at-sage

Javier F, Río D, Cabello F, Fernández I. Influence of substance use on the erectile response in a sample of drug users PALABRAS CLAVE. International Journal of Clinical and Health Psychology. 2015 [cited 2023 Jun 23];15:37–43. Available from: www.elsevier.es/ijchp

Yang YJ, Chien WC, Chung CH, Hong KT, Yu YL, Hueng DY, et al. Risk of erectile dysfunction after traumatic brain injury: a nationwide population-based cohort study in Taiwan. Am J Mens Health. 2018 [cited 2022 Dec 16];12:913–25. Available from: https://pubmed.ncbi.nlm.nih.gov/29325484/

Levine LA. Peyronie’s disease and erectile dysfunction: current understanding and future direction. Indian J Urol. 2006;22:246–250. Available from: http://www.indianjurol.com.

Deng N, Thirumavalavan N, Beilan JA, Tatem AJ, Hockenberry MS, Pastuszak AW, et al. Sexual dysfunction and infertility in the male spina bifida patient. Transl Androl Urol. 2018. https://doi.org/10.21037/tau.2018.10.08. [cited 2023 Jun 23];7: 941 . Available from: /pmc/articles/PMC6256049/.

Article  PubMed  PubMed Central  Google Scholar 

Mutha AS, Kulkarni VR, Bhagat SB, Beldar AS, Patel SB. An observational study to evaluate the prevalence of erectile dysfunction (ED) and prescribing pattern of drugs in patients with ED visiting an andrology specialty clinic, Mumbai: 2012–14. J Clin Diagn Res. 2015 [cited 2023 Jun 23];9:PC08. Available from: /pmc/articles/PMC4572994/

Mutha AS, Kulkarni VR, Bhagat SB, Beldar AS, Patel SB. An observational study to evaluate the prevalence of erectile dysfunction (ED) and prescribing pattern of drugs in patients with ED visiting an andrology specialty clinic, Mumbai: 2012–14. J Clin Diagn Res. 2015 [cited 2022 Dec 16];9:PC08. Available from: /pmc/articles/PMC4572994/

Su Q, Wang R, Luo Y, Tang Q, Wang K. Genetic association of lipid-lowering drug target genes with erectile dysfunction and male reproductive health. Front Endocrinol (Lausanne). 2024;15:1362499.

Article  PubMed  Google Scholar 

Mulhall JP, Luo X, Zou KH, Stecher V, Galaznik A. Relationship between age and erectile dysfunction diagnosis or treatment using real-world observational data in the USA. Int J Clin Pract. 2016 [cited 2022 Dec 16];70:1012–8. Available from: https://pubmed.ncbi.nlm.nih.gov/28032424/

Schuppe HC, Pilatz A, Hossain H, Meinhardt A, Bergmann M, Haidl G, et al. Orchitis und Infertilität. Der Urologe 2010 49:5. 2010 [cited 2022 Dec 16];49:629–35. Available from: https://link.springer.com/article/10.1007/s00120-010-2256-1

Papadopoulou E, Varouktsi A, Lazaridis A, Boutari C, Doumas M. Erectile dysfunction in chronic kidney disease: from pathophysiology to management. World J Nephrol. 2015 [cited 2022 Dec 16];4:379. Available from: /pmc/articles/PMC4491929/.

Das ND, Song KM, Yin GN, Batbold D, Kwon MH, Kwon KD, et al. Xenogenic transplantation of human breast adipose-derived stromal vascular fraction enhances recovery of erectile function in diabetic mice. Biol Reprod. 2014 [cited 2022 Dec 16];90. Available from: https://academic.oup.com/biolreprod/article/90/3/661–10/2514325.

Polland A, Berookhim BM. Fertility concerns in men with genitourinary malignancies: treatment dilemmas, fertility options, and medicolegal considerations. Urol Oncol. 2016 [cited 2022 Dec 16];34:399–406. Available from: https://pubmed.ncbi.nlm.nih.gov/27283219/

Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol. 2010 [cited 2022 Dec 16];57:804–14. Available from: https://pubmed.ncbi.nlm.nih.gov/20189712/.

Hatzimouratidis K, Salonia A, Adaikan G, Buvat J, Carrier S, El-Meliegy A, et al. Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2016 [cited 2022 Dec 16];13:465–88. Available from: https://pubmed.ncbi.nlm.nih.gov/27045254/

SID 135021181 - PubChem. [cited 2022 Dec 16]. Available from: https://pubchem.ncbi.nlm.nih.gov/substance/135021181

Vardenafil | C23H32N6O4S - PubChem. [cited 2022 Dec 16]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/135400189.

Tadalafil | C22H19N3O4 - PubChem. [cited 2022 Dec 16]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/110635.

Avanafil | C23H26ClN7O3 - PubChem. [cited 2022 Dec 16]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/9869929

Enna SJ, Bylund DB. Alprostadil. xPharm: The Comprehensive Pharmacology Reference. 2019 [cited 2022 Dec 16];1–1. Available from: http://europepmc.org/books/NBK542217

Caverject facts and comparisons at Drugs.com. [cited 2022 Dec 16]. Available from: https://web.archive.org/web/20121026075757/http://www.drugs.com/cdi/caverject.html.

Edex Facts and Comparisons at Drugs.com. [cited 2022 Dec 16]. Available from: https://web.archive.org/web/20121026073759/http://www.drugs.com/cdi/edex.html

Vitaros 3 mg/g cream - Summary of Product Characteristics (SPC) - (eMC). [cited 2022 Dec 16]. Available from: https://web.archive.org/web/20150211142552/https://www.medicines.org.uk/emc/medicine/28866

Muse suppository facts and comparisons at Drugs.com. [cited 2022 Dec 16]. Available from: https://web.archive.org/web/20130119131710/http://www.drugs.com/cdi/muse-suppository.html

Treatment for Erectile Dysfunction | NIDDK. [cited 2022 Dec 16]. Available from: https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/treatment

Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013 [cited 2023 Jun 23];381:153–65. Available from: https://pubmed.ncbi.nlm.nih.gov/23040455/

Lue TF. Erectile dysfunction. Wood AJJ, editor. 2000 [cited 2023 Jun 23];342:1802–13. Available from: https://www.nejm.org/doi/full/10.1056/NEJM200006153422407.

Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, et al. Erectile dysfunction. Nat Rev Dis Primers. 2016 [cited 2022 Dec 16];2. Available from: https://pubmed.ncbi.nlm.nih.gov/27188339/.

Najari BB, Kashanian JA. Erectile dysfunction. JAMA. 2016 [cited 2022 Dec 16];316:1838. Available from: https://pubmed.ncbi.nlm.nih.gov/27802547/.

Lue TF. Erectile dysfunction. Wood AJJ, editor. N Engl J Med. 2000 [cited 2022 Dec 16];342:1802–13. Available from: https://pubmed.ncbi.nlm.nih.gov/10853004/

McVary KT. Clinical practice. Erectile dysfunction. N Engl J Med. 2007 [cited 2022 Dec 16];357:2472–81. Available from: https://pubmed.ncbi.nlm.nih.gov/18077811/.

Burnett AL, Nehra A, Breau RH, Culkin DJ, Faraday MM, Hakim LS, et al. Erectile Dysfunction: AUA Guideline. J Urol. 2018 [cited 2022 Dec 15];200:633–41. Available from: https://pubmed.ncbi.nlm.nih.gov/29746858/.

Erectile Dysfunction - PubMed. [cited 2023 Dec 27]. Available from: https://pubmed.ncbi.nlm.nih.gov/32965924/

Mäkelä J, Toppari J. Encyclopedia of Reproduction. Vol I Testis physiology: seminiferous cycle. Jégou B, Skinner M, editors. Encyclopedia of Reproduction. 2008;3868.

Piao S, Kim IG, Lee JY, Hong SH, Kim SW, Hwang TK, et al. Therapeutic effect of adipose-derived stem cells and BDNF-immobilized PLGA membrane in a rat model of cavernous nerve injury. J Sex Med. 2012;9:1968–79.

Article  CAS  PubMed  Google Scholar 

Matz EL, Terlecki R, Zhang Y, Jackson J, Atala A. Stem cell therapy for erectile dysfunction. Sex Med Rev. Elsevier B.V.; 2019. pp. 321–8.

Alwaal A, Zaid UB, Lin CS, Lue TF. Stem cell treatment of erectile dysfunction. Adv Drug Deliv Rev. Elsevier B.V.; 2015. pp. 137–44.

Lin CS, Xin ZC, Wang Z, Deng C, Huang YC, Lin G, et al. Stem cell therapy for erectile dysfunction: A critical review. Stem Cells Dev. 2012;21:343–51.

Article  CAS  PubMed  Google Scholar 

Protogerou V, Chrysikos D, Karampelias V, Spanidis Y, el Bisari S, Troupis T. Erectile dysfunction treatment using stem cells: a review. Medicines. 2021. https://doi.org/10.3390/medicines8010002. [cited 2022 Dec 16];8: 2 . Available from: /pmc/articles/PMC7825548/.

Article  PubMed  PubMed Central  Google Scholar 

Alwaal A, Zaid UB, Lin CS, Lue TF. Stem cell treatment of erectile dysfunction. Adv Drug Deliv Rev. 2015 [cited 2022 Dec 15];82–83:137–44. Available from: https://pubmed.ncbi.nlm.nih.gov/25446142/

Ouyang B, Sun X, Han D, Chen S, Yao B, Gao Y, et al. Human urine-derived stem cells alone or genetically-modified with FGF2 Improve type 2 diabetic erectile dysfunction in a rat model. PLoS One. 2014 [cited 2022 Dec 15];9:e92825–e92825. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24663037/?tool=EBI

Feng H, Liu Q, Deng Z, Li H, Zhang H, Song J, et al. Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. Stem Cell Res Ther. 2022;13:13.

Article  Google Scholar 

Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, et al. NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats. Front Endocrinol (Lausanne). 2022;13:913296.

Sun T, Xu W, Tu B, Wang T, Liu J, Liu K, et al. Engineered adipose-derived stem cells overexpressing RXFP1 via CRISPR activation ameliorate erectile dysfunction in diabetic rats. Antioxidants. 2023;12: 171.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu J, Chen Z, Zhong F, Yang W, Ouyang X, Ma X, et al. Transplantation of human gingiva-derived mesenchymal stem cells ameliorates neurotic erectile dysfunction in a rat model. Front BioengBiotechnol. 2021;9:9.

Google Scholar 

Piao S, Kim IG, Lee JY, Hong SH, Kim SW, Hwang TK, et al. Therapeutic effect of adipose-derived stem cells and BDNF-immobilized PLGA membrane in a rat model of cavernous nerve injury. J Sex Med. 2012 [cited 2022 Dec 16];9:1968–79. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1743-6109.2012.02760.x.

Ti Y, Yang M, Chen X, Zhang M, Xia J, Lv X, et al. Comparison of the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells and adipose-derived stem cells on erectile dysfunction in a rat model of bilateral cavernous nerve injury. Front Bioeng Biotechnol. 2022;10:1019063.

Article  PubMed  PubMed Central  Google Scholar 

Protogerou V, El BS, Michalopoulos E, Mallis P, Chrysikos D, Samolis AA, et al. The combined use of stem cells and platelet lysate plasma for the treatment of erectile dysfunction: a pilot study–6 months results. Medicines. 2020;7: 14.

Article  PubMed  PubMed Central  Google Scholar 

Al Demour S, Adwan S, Jafar H, Rahmeh R, Alhawari H, Awidi A. Safety and efficacy of 2 intracavernous injections of allogeneic Wharton’s Jelly-derived mesenchymal stem cells in diabetic patients with erectile dysfunction: phase 1/2 clinical trial. Urol Int. 2021;105:935–43.

Article  CAS  PubMed  Google Scholar 

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