2,5-Dihydropyrrole derivatives are considered privileged structures as reflected by their presence in many biological activities and therapeutic agents. Herein, we develop a concise and efficient method utilizing a commercially available copper salt as catalyst to facilitate the formation of 2,5-dihydropyrrole from propargyl amine and diazo ester. This reaction proceeds via the formation of N-ylide followed by bond cleavage/recombination. Control experiments and density functional theory (DFT) calculations provide a detailed analysis of the reaction pathway. The key features of this protocol include simple operation, readily available starting materials, mild conditions, and high atom economy. In addition, the gram-scale preparation experiment and the transformations of 2,5-dihydropyrroles demonstrate the potential applicability of our synthetic method.
You have access to this article
留言 (0)