We have developed a protocol for the β-C(sp2)‒H chalcogenylation of both endo- and exocyclic enamides using stoichiometric amount of molecular iodine and dichalcogenides at room temperature, completing the reaction within a mere five minutes and in an open-air environment. This method yields a diverse array of sulfenylated and selenated enamide compounds, including 5-phenylsulfanyl and 5-phenylselanyl uracil, under mild and metal-free conditions. Treating the endocyclic chalcogenated enamides with PIFA for five minutes, through a sequential one-pot process, leads to valuable 5-thio- and 5-seleno-2-pyridones with a free C-3 position.

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