Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159(4):709–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh PP, Demmitt BA, Nath RD, Brunet A. The genetics of aging: a vertebrate perspective. Cell. 2019;177(1):200–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denzel MS, Lapierre LR, Mack HID. Emerging topics in C. elegans aging research: transcriptional regulation, stress response and epigenetics. Mech Ageing Dev. 2019;177:4–21.

Article  CAS  PubMed  Google Scholar 

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, et al. Interventions to slow aging in humans: are we ready? Aging Cell. 2015;14(4):497–510.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366(6454):366461a0.

Article  Google Scholar 

Friedman DB, Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988;118(1):75–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277(5328):942–6.

Article  CAS  PubMed  Google Scholar 

Kenyon CJ. The genetics of ageing. Nature. 2010;464(7288):504–12.

Article  CAS  PubMed  Google Scholar 

Hahm JH, Kim S, DiLoreto R, Shi C, Lee SJV, Murphy CT, et al. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun. 2015;6(1):8919.

Article  CAS  PubMed  Google Scholar 

Statzer C, Reichert P, Dual J, Ewald CY. Longevity interventions temporally scale healthspan in Caenorhabditis elegans. Iscience. 2022;25(3):103983.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bansal A, Zhu LJ, Yen K, Tissenbaum HA. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc National Acad Sci. 2015;112(3):E277–86.

Article  CAS  Google Scholar 

Ewald CY, Castillo-Quan JI, Blackwell TK. Untangling longevity, dauer, and healthspan in Caenorhabditis elegans insulin/IGF-1-signalling. Gerontology. 2017;64(1):96–104.

Article  PubMed  Google Scholar 

Ewald CY, Landis JN, Abate JP, Murphy CT, Blackwell TK. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 2015;519(7541):97–101.

Article  CAS  PubMed  Google Scholar 

Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. WormBook. 2013. p. 1–43. https://doi.org/10.1895/wormbook.1.164.1.

Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, et al. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics. 1998;150(1):129–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Libina N, Berman JR, Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell. 2003;115(4):489–502.

Article  CAS  PubMed  Google Scholar 

Riddle DL, Swanson MM, Albert PS. Interacting genes in nematode dauer larva formation. Nature. 1981;290(5808):668–71.

Article  CAS  PubMed  Google Scholar 

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, et al. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921–1921.

Article  CAS  PubMed  Google Scholar 

Lithgow GJ, White TM, Melov S, Johnson TE. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci. 1995;92(16):7540–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003;424(6946):277–83.

Article  CAS  PubMed  Google Scholar 

Dillin A, Crawford DK, Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science. 2002;298(5594):830–4.

Article  CAS  PubMed  Google Scholar 

Venz R, Pekec T, Katic I, Ciosk R, Ewald CY. End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies. Elife. 2021;10:e71335.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang YP, Zhang WH, Zhang P, Li Q, Sun Y, Wang JW, et al. Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost. Nat Commun. 2022;13(1):6339.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roy C, Molin L, Alcolei A, Solyga M, Bonneau B, Vachon C, et al. DAF-2/insulin IGF-1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues. Aging Cell. 2022;21(8):e13660.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Ward JD, Cheng Z, Dernburg AF. The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans. Development. 2015;142(24):4374–84.

CAS  PubMed  PubMed Central  Google Scholar 

Podshivalova K, Kerr RA, Kenyon C. How a mutation that slows aging can also disproportionately extend end-of-life decrepitude. Cell Rep. 2017;19(3):441–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans : a role for heat-shock factor and bacterial proliferation. Genetics. 2002;161(3):1101–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Gilliat AF, Ziehm M, Turmaine M, Wang H, Ezcurra M, et al. Two forms of death in ageing Caenorhabditis elegans. Nat Commun. 2017;8(1):15458.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gems D, Riddle DL. Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics. 2000;154(4):1597–610.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ezcurra M, Benedetto A, Sornda T, Gilliat AF, Au C, Zhang Q, et al. C. elegans eats its own intestine to make yolk leading to multiple senescent pathologies. Curr Biol. 2018;28(16):2544-2556.e5.

Article  CAS  PubMed  PubMed Central 

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