Research on the care of critically ill high-risk infants with bronchiolitis has been limited to date.23 Despite the existence of national guidelines pertaining to the management of acute bronchiolitis, little impact has been shown for the management of patients in the PICU with severe disease.24 For example, the NICE guidelines recommended against the use of nebulised therapies for the management of patients in the PICU and advised the use of continuous positive airway pressure (CPAP) in patients with impending respiratory failure.14 However, small regional studies published since the 2015 NICE guidelines have found that the use of nebulised therapies, including hypertonic saline, have increased.24 Additionally, non-invasive ventilation (NIV) such as high-flow oxygen therapy has increased, while the use of CPAP decreased.24

Available guidelines rarely included specific guidance for the management of infants with bronchiolitis in the PICU setting.1 Significantly, acute bronchiolitis accounts for around 13% of PICU admissions in the UK, contributing a significant burden on the availability of PICU beds.1 Additionally, it has been shown that those infants experiencing severe disease and admission to the PICU are those with identifiable risk factors including prematurity and chronic medical conditions as above.1 As shown in Table 1, the majority of RCTs included in the NICE guidelines (2015) excluded those infants with any high-risk condition, comorbidity, or requiring escalation of care.14 The greatest percentage of patients excluded from the clinical trial data included those with underlying respiratory disease, followed by those with underlying cardiovascular disease. Additionally, a large percentage of patients were excluded for having received previous medication or treatment, such as bronchodilators or corticosteroids, as well as having any history of atopy including asthma, wheeze, atopic dermatitis, or allergic rhinitis. Over half of the studies excluded patients who required escalation of care and/or PICU management. Finally, over 30% of studies excluded those who were premature and around 7% of studies excluded congenital anomalies such as Down Syndrome. Given the exclusion of high-risk infants from trials which are subsequently used to make evidence-based recommendations, this significantly limits the generalisability of the guidelines among infants with various underlying health conditions. Based on this observation, we hypothesize that there is a significant gap in the research pertaining to the management of high-risk infants experiencing bronchiolitis.

The National Institute for Health and Care Excellence (NICE) guidelines on bronchiolitis management and diagnosis in children were published in 2015 and serve as a cumulative management protocol developed from over 90 RCTs grouped based on treatment intervention.14 Using the findings of the RCTs, recommendations were made regarding the use of different management techniques. For example, regarding oxygen supplementation for babies and children with bronchiolitis, it is recommended that supplemental oxygen be administered to children aged 6 weeks and above, and to babies under 6 weeks of age or children of any age with underlying health conditions, if their measured oxygen saturations are persistently below 90% and 92%, respectively. However, the best method of oxygen delivery could not be determined. The recommendation of an oxygen saturation threshold of 90% in infants and children >6 weeks, for the provision of supplemental oxygen and discharge from the hospital, was largely based on the results of an RCT which compared an oxygen saturation threshold of 90% to a threshold of 94%.25 This RCT was conducted in patients >6 weeks of age with fewer comorbidities and less risk of poor outcomes compared to those children with bronchiolitis typically seen in a hospital setting.25 The NICE guideline notes that there was no evidence available on oxygen saturation targets for patients at higher risk of severe disease (patients aged <6 weeks and children of any age with underlying health conditions).14 Therefore, the decision to recommend a 92% threshold for high-risk patients was not evidence-based, but instead was made on professional judgement. Additionally, it is recommended to give fluids via nasogastric or orogastric tube when oral hydration is inadequate and escalate to isotonic intravenous fluids in those with impending respiratory failure. It states that chest physiotherapy should not be performed, however, consideration should be given when the child presents with comorbidities that lead to difficulties clearing secretions. It was also found that there was no clear benefit for the routine use of antibiotics. The available evidence on the use of hypertonic saline was also assessed, but it was found to not offer any reduction in hospital stay when compared to no treatment and therefore was not recommended. It was advised that upper airway suctioning should not be routinely performed for bronchiolitis in children but can be considered to alleviate distress when feeding difficulties are present. Additionally, in those presenting with apnoea, it is stated that upper airway suctioning is always recommended. Finally, two management techniques, Heliox - the gas mixture of helium and oxygen and Montelukast, were found to have limited and contradictory evidence and therefore further research was recommended.26,27

Infants with high-risk conditions have an increased likelihood of hospitalisation for bronchiolitis and are more likely to be encountered in a secondary or tertiary care setting compared to those with no underlying medical comorbidities.10 Despite the higher rate of hospitalisation and death, this search has confirmed that there is paucity of evidence pertaining to the PICU management of this patient cohort in the literature, echoing the findings of Lin and Madikans (2015).23

The vast majority of studies measured methods of oxygen delivery, which remains the mainstay of treatment for all patients with bronchiolitis with saturations below 92%.14 Although the need for supplemental oxygen is a universally accepted management, questions remain regarding the optimal method of delivery. When comparing HFNC and CPAP, Metge et al.28 found no difference between both modes of delivery in terms of the patient’s clinical parameters or length of PICU stay.24 Habra et al.29 conducted a larger study investigating NIV (CPAP and BiPAP), however, among the exclusion criteria were patients deemed high-risk with underlying respiratory or congenital heart disease28 Although a smaller study, the same exclusion criteria did not apply for the Metge et al.28 study, which only excluded infants with endotracheal intubation at time of admission to ICU.24 These findings are in contrast to those of Griffiths et al.24 which found a trend favouring high-flow oxygen therapy away from CPAP since the update of the NICE guidelines in 2015, however, this was studied in those with less severe disease prior to PICU admission.14,24 Despite these findings, the use of NIV was associated with favourable outcomes in several of the studies whereas HFNC was associated with greater patient tolerance and decreased risk of nasal injury.30,31,32,33,34,35

Heliox therapy utilises a helium-oxygen gas mixture and works by reducing airway resistance through decreasing turbulent flow and in turn reduces the work of breathing.36 This intervention also appears to have anti-inflammatory mechanisms.37 Heliox has been investigated for use in bronchiolitis management and was reported on in the NICE guidelines.14 However, they did not recommend its use due to limited and contradictory evidence and instead indicated the need for further research. Our search yielded two studies looking at the use of heliox therapy in the PICU management of bronchiolitis.27,38 In a small study conducted by Liet et al.38 heliox therapy did improve overall respiratory status in RSV bronchiolitis and decreased PICU length of stay.38 This reaffirmed the findings of Martinón-Torres et al.26 who had similar findings across a population of 38 critically ill infants.27 However, both these studies had relatively small sample sizes and research on this intervention for bronchiolitis has not been expanded. There may be limited recent research on this intervention as the use of high oxygen concentrations in those who are critically unwell with bronchiolitis is contraindicated, as well as the low-density gas causing issues in the ventilator readings.39,40

Management outside of ventilation strategies included a variety of more novel therapeutic methods. Those with positive results included the use of dexamethasone, nutritional supplementation, and diuretics. Dexamethasone administered prophylactically prior to extubation was shown to significantly decrease the risk of reintubation when compared to patients who did not receive a prophylactic dose.41 However, similar to the majority of studies reviewed, patients with upper airway pathology were excluded. Additionally, this study did not report on the possible adverse effects of dexamethasone, which includes hypertension, glucosuria, and immunosuppression. This may alter the risk-benefit ratio of administering this medication to high-risk patients who may be vulnerable to the side effects.

Nutritional supplementation, focusing on ensuring adequate protein anabolism and supplementation, was another management technique investigated in the PICU patient population. In this study by De Betue et al.42 18 critically ill infants were given additional protein supplementation which ensured nutritional needs were met.42 They found that the patients who were given the protein-enriched formula had markedly higher protein balance and more favourable outcomes. In addition to this, the infants receiving the protein-enriched formula were significantly lower in gestational age than the control group, which along with the small population size, may threaten the credibility of the results. However, this may indicate a greater level of importance in adequate nutrition for critically ill infants with low weight at admission, especially as this is a well-established risk factor for poor outcomes.43

There is conflicting evidence on the use of furosemide in this clinical setting. A randomised controlled trial by Williamson et al.44 found no improvement in respiratory distress in infants with moderate to severe bronchiolitis treated with single-dose furosemide.44 However, in the study by Agasthya et al.45 furosemide was found to improve oxygenation in ventilated infants with severe bronchiolitis during fluid overload states.45 Furosemide reduced the need for prolonged mechanical ventilation, decreased PICU stay, and improved oxygenation. After 24 h, there were modest improvements in FiO2 with no evidence of hemodynamic instability or electrolyte disturbance. Future research in this area may produce an evidence base for this intervention during acute management.46,47 The potential decrease in the length of mechanical ventilation reduces the risk of other complications such as ventilator-associated infections, atelectasis, and pneumothoraces.48

Some interventions for the PICU management of bronchiolitis in high-risk infants did not display favourable outcomes. These included ribavirin, erythropoietin (EPO), caffeine, and RSV immune globulin (RSVIG). Aerosolised ribavirin showed a lack of effectiveness in treating RSV bronchiolitis across 41 patients.49 No differences were observed between the patients who received the ribavirin and the cohort who received the placebo (normal saline). In their 2003 paper, Jacobs et al. studied the clinical benefit of the administration of exogenous EPO for critically ill infants with bronchiolitis.50 EPO showed no difference in improvement when administered, quantified as the need for transfusions, between the two groups. However, the patients receiving EPO injections had marginally greater reticulocyte counts compared to the control patients. Heuzé et al.50 assessed the benefit of caffeine administration in infants with bronchiolitis-related apnoea in the PICU.51 However, in this study, the length of PICU stay and the number of patients requiring mechanical ventilation remained the same for both the caffeine and control groups. Lastly, an older study by Rodriguez et al.51 looked at whether RSVIG could be of benefit for the treatment of acute bronchiolitis.52 Although not significant, the administration of RSVIG resulted in fewer hospital days, but only in those infants with severe disease. Overall, these interventions were not of significant benefit in the management of bronchiolitis and additional large RCTs are needed to confirm these findings.

As is often quoted in medicine – Prevention is better than cure. In that respect, an imminent healthcare development that may drastically reduce the prevalence of severe bronchiolitis in high-risk infants is the implementation of RSV immunisation in children. The newest agent, Nirsevimab, is a respiratory syncytial virus F protein‑directed fusion inhibitor, which reduces the risk of severe RSV disease by approximately 80%.53 The implementation of this vaccine in many countries around the world is imminent as it is now recommended by the Centres for Disease Control and Prevention for all infants under 8 months of age, and high-risk infants aged 8-19 months.53 It protects a child for the duration of an RSV season (around 5 months).52 Palivizumab, a monoclonal antibody with similar mechanism of action but shorter duration of action than Nirsevimab, has been used for many years exclusively in the setting of high-risk infants under 24 months for the prevention of severe disease to great effect – reducing infection rates and associated hospitalisation53. The wider implementation of RSV vaccination in infants will hopefully reduce the morbidity and mortality associated with RSV infection in high-risk infants.

Overall, our study reported on papers with higher levels of evidence I, II and III, which strengthens the impact of the results. However, as was seen in the 2015 NICE guidelines; as well as other evidence-based guidelines include those from the American Association of Paediatrics, Canadian Paediatric Society, and The Royal Australasian College of Physicians; a large proportion of studies that guide management exclude patients on the basis of their medical comorbidities. A similar finding was seen among the studies identified in our search. This limits our results as, although studies on the management of patients in the PICU were identified, a significant proportion of those management techniques were not trialled on high-risk patients. Additionally, utilisation of our clearly defined search criteria may have limited our results such that only studies conducted on patients within the PICU setting were included, excluding high-risk patients that may have been managed on a ward or high dependency unit (HDU). Lastly, a large proportion of the studies reviewed had small sample sizes and therefore these management techniques should be examined in larger trials.

Finally, as previously mentioned, infants with high-risk conditions have an increased chance of being hospitalised for bronchiolitis.10 Despite this population experiencing more severe illness and morbidity, they have been excluded quite consistently from clinical studies. From the studies extracted for the purpose of this review, it is clear that a lack of evidence exists pertaining to the management of high-risk patients with bronchiolitis. It highlights the need for evidence-based trials with a particular preference for prospective RCTs. These should explore the above interventions and management techniques in high-risk infants with underlying medical comorbidities requiring ICU management.