Ärnlöv J, Larsson A. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the global burden of Disease Study 2013. Lancet. 2015;386(9995):743–800.

Article  Google Scholar 

McGlashan TH. Early detection and intervention in schizophrenia: research. Schizophr Bull. 1996;22(2):327–45.

Article  CAS  PubMed  Google Scholar 

Cuthbert BN, Morris SE. Evolving concepts of the Schizophrenia Spectrum: A Research Domain Criteria Perspective. Front Psychiatry. 2021;12:641319.

Article  PubMed  PubMed Central  Google Scholar 

Laurens KR, et al. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry. 2015;15:205.

Article  PubMed  PubMed Central  Google Scholar 

Rogers J. A shared pathway connects schizophrenia and bipolar disorder. Nat Rev Neurosci. 2023;24(1):2.

Article  CAS  PubMed  Google Scholar 

Fisher HL, et al. Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study. Psychol Med. 2013;43(10):2077–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feinberg I. Cortical pruning and the development of schizophrenia. Schizophr Bull. 1990;16(4):567–70.

Article  CAS  PubMed  Google Scholar 

Keshavan M, Lizano P, Prasad K. The synaptic pruning hypothesis of schizophrenia: promises and challenges. World Psychiatry. 2020;19(1):110–1.

Article  PubMed  PubMed Central  Google Scholar 

Mollon J, Reichenberg A. Cognitive development prior to onset of psychosis. Psychol Med. 2018;48(3):392–403.

Article  CAS  PubMed  Google Scholar 

Howes OD, et al. Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes. Neuropsychopharmacology. 2023;48(1):151–67.

Article  PubMed  Google Scholar 

Esterlis I, Holmes S. First in vivo evaluations of synaptic density alterations in the brain. Neuropsychopharmacology. 2022;47(1):381–2.

Article  PubMed  Google Scholar 

Navlakha S, Barth AL, Bar-Joseph Z. Decreasing-rate Pruning optimizes the construction of efficient and robust distributed networks. PLoS Comput Biol. 2015;11(7):e1004347.

Article  PubMed  PubMed Central  Google Scholar 

Huttenlocher PR. Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res. 1979;163(2):195–205.

Article  CAS  PubMed  Google Scholar 

Tessier CR, Broadie K. Activity-dependent modulation of neural circuit synaptic connectivity. Front Mol Neurosci. 2009;2:8.

Article  PubMed  PubMed Central  Google Scholar 

Sellgren CM, et al. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019;22(3):374–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forrest MP, Parnell E, Penzes P. Dendritic structural plasticity and neuropsychiatric disease. Nat Rev Neurosci. 2018;19(4):215–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Berdenis A, et al. Synapse Pathology in Schizophrenia: a Meta-analysis of postsynaptic elements in Postmortem Brain studies. Schizophr Bull. 2020;46(2):374–86.

Google Scholar 

Calhoun ME, et al. Comparative evaluation of synaptophysin-based methods for quantification of synapses. J Neurocytol. 1996;25(12):821–8.

Article  CAS  PubMed  Google Scholar 

Serrano ME, et al. Imaging synaptic density: the Next Holy Grail of Neuroscience? Front Neurosci. 2022;16:796129.

Article  PubMed  PubMed Central  Google Scholar 

Osimo EF, et al. Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures. Mol Psychiatry. 2019;24(4):549–61.

Article  CAS  PubMed  Google Scholar 

Eastwood SL, Burnet PW, Harrison PJ. Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia. Neuroscience. 1995;66(2):309–19.

Article  CAS  PubMed  Google Scholar 

Gogtay N, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004;101(21):8174–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreou C, Borgwardt S. Structural and functional imaging markers for susceptibility to psychosis. Mol Psychiatry. 2020;25(11):2773–85.

Article  PubMed  PubMed Central  Google Scholar 

Cannon TD, et al. Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk. Biol Psychiatry. 2015;77(2):147–57.

Article  PubMed  Google Scholar 

Schizophrenia Working Group of the Psychiatric Genomics. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511(7510):421–7.

Article  Google Scholar 

Sekar A, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530(7589):177–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam M, et al. Pleiotropic Meta-analysis of Cognition, Education, and Schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. Am J Hum Genet. 2019;105(2):334–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grove J, et al. Identification of common genetic risk variants for autism spectrum disorder. Nat Genet. 2019;51(3):431–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Radhakrishnan R et al. In vivo evidence of lower synaptic vesicle density in schizophrenia. Mol Psychiatry, 2021.

Bajjalieh SM, et al. Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci. 1994;14(9):5223–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mercier J, Provins L, Valade A. Discovery and development of SV2A PET tracers: potential for imaging synaptic density and clinical applications. Drug Discov Today Technol. 2017;25:45–52.

Article  PubMed  Google Scholar 

Finnema SJ, et al. Imaging synaptic density in the living human brain. Sci Transl Med. 2016;8(348):348ra96.

Article  PubMed  Google Scholar 

Mattheisen M, et al. Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia. Schizophr Res. 2012;141(2–3):262–5.

Article  PubMed  Google Scholar