Liu G, Zhu M, Zhang M, Pan F. Emerging role of IGF-1 in prostate cancer: a promising biomarker and therapeutic target. Cancers. 2023;15:1287.
Article CAS PubMed PubMed Central Google Scholar
Brahmkhatri VP, Prasanna C, Atreya HS. Insulin-like growth factor system in cancer: novel targeted therapies. Biomed Res Int. 2015;2015:538019.
Article PubMed PubMed Central Google Scholar
Pierce JR, Martin BJ, Rarick KR, Alemany JA, Staab JS, Kraemer WJ, et al. Growth hormone and insulin-like growth Factor-I molecular weight isoform responses to resistance exercise are sex-dependent. Front Endocrinol (Lausanne). 2020;21:571.
Ascenzi F, Barberi L, Dobrowolny G, Villa Nova Bacurau A, Nicoletti C, Rizzuto E, et al. Effects of IGF-1 isoforms on muscle growth and sarcopenia. Aging Cell. 2019;18:e12954.
Article PubMed PubMed Central Google Scholar
Dai Z, Wu F, Yeung EW, Li Y. IGF-IEc expression, regulation and biological function in different tissues. Growth Horm IGF Res. 2010;20:275–81.
Article CAS PubMed Google Scholar
Matheny RW Jr., Nindl BC, Adamo ML. Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology. 2010;151:865–75.
Article CAS PubMed PubMed Central Google Scholar
Schlegel W, Raimann A, Halbauer D, Scharmer D, Sagmeister S, Wessner B, et al. Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor-a splice variant of IGF-1 within the growth plate. PLoS One. 2013;8:e76133.
Article CAS PubMed PubMed Central Google Scholar
Armakolas A, Philippou A, Panteleakou Z, Nezos A, Sourla A, Petraki C, et al. Preferential expression of IGF-1Ec (MGF) transcript in cancerous tissues of human prostate: evidence for a novel and autonomous growth factor activity of MGF E peptide in human prostate cancer cells. Prostate. 2010;70:1233–42.
Article CAS PubMed Google Scholar
Armakolas A, Kaparelou M, Dimakakos A, Papageorgiou E, Armakolas N, Antonopoulos A, et al. Oncogenic role of the Ec peptide of the IGF-1Ec Isoform in prostate cancer. Mol Med. 2015;21:167–79.
Article CAS PubMed PubMed Central Google Scholar
Armakolas A, Dimakakos A, Loukogiannaki C, Armakolas N, Antonopoulos A, Florou C, et al. IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumours. Mol Med. 2018;24:6.
Article CAS PubMed PubMed Central Google Scholar
Savvani A, Petraki C, Msaouel P, Diamanti E, Xoxakos I, Koutsilieris M. IGF-IEc expression is associated with advanced clinical and pathological stage of prostate cancer. Anticancer Res. 2013;33:2441–5.
Xoxakos I, Petraki C, Msaouel P, Armakolas A, Grigorakis A, Stefanakis S, et al. Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in prostate cancer. Anticancer Res. 2020;40:709–18.
Article CAS PubMed Google Scholar
Bastide C, Bagnis C, Mannoni P, Hassoun J, Bladou F. A Nod Scid mouse model to study human prostate cancer. Prostate Cancer Prostatic Dis. 2002;5:311–5.
Article CAS PubMed Google Scholar
Tanaka S, Kobayashi W, Haraguchi M, Ishihata K, Nakamura N, Ozawa M. Snail1 expression in human colon cancer DLD-1 cells confers invasive properties without N-cadherin expression. Biochem Biophys Rep. 2016;8:120–6.
PubMed PubMed Central Google Scholar
Li H, Batth IS, Qu X, Xu L, Song N, Wang R, et al. IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights. Mol Cancer. 2017;16:6.
Article CAS PubMed PubMed Central Google Scholar
Osher E, Macaulay VM. Therapeutic targeting of the IGF axis. Cells. 2019;8:895.
Article CAS PubMed PubMed Central Google Scholar
Simpson A, Petnga W, Macaulay VM, Weyer-Czernilofsky U, Bogenrieder T. Insulin-Like Growth Factor (IGF) pathway targeting in cancer: role of the IGF axis and opportunities for future combination studies. Target Oncol. 2017;12:571–97.
Article PubMed PubMed Central Google Scholar
Gao J, Chesebrough JW, Cartlidge SA, Ricketts SA, Incognito L, Veldman-Jones M, et al. Dual IGF-I/II–neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumour growth. Cancer Res. 2011;71:1029–40.
Article CAS PubMed Google Scholar
Olmos D, Okuno S, Schuetze SM, Paccagnella ML, Yin D, Gualberto A, et al. Safety, pharmacokinetics and preliminary activity of the anti–IGF-IR antibody CP-751,871 in patients with sarcoma. JCO Suppl. 2008;6:122.
Kurzrock R, Patnaik A, Aisner J, Warren T, Leong S, Benjamin R, et al. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumours. Clin Cancer Res. 2010;16:2458–65.
Article CAS PubMed Google Scholar
Al-Samerria S, Radovick S. The role of Insulin-like Growth Factor-1 (IGF-1) in the control of neuroendocrine regulation of growth. Cells. 2021;10:2664.
Article CAS PubMed PubMed Central Google Scholar
Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, et al. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Investig. 2002;110:771–81.
Article CAS PubMed PubMed Central Google Scholar
Prosser CG. Insulin-like growth factors in milk and mammary gland. J Mammary Gland Biol Neoplasia. 1996;1:297–306.
Article CAS PubMed Google Scholar
Hong H, Cui ZZ, Zhu L, Fu SP, Rossi M, Cui YH, et al. Central IGF1 improves glucose tolerance and insulin sensitivity in mice. Nutr Diabetes. 2017;7:2.
Article PubMed PubMed Central Google Scholar
Kandalla PK, Goldspink G, Butler-Browne G, Mouly V. Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and inducean increase in their fusion potential at different ages. Mech Ageing Dev. 2011;132:154–62.
Article CAS PubMed Google Scholar
Hill M, Wernig A, Goldspink G. Muscle satellite (stem) cell activation during local tissue injury and repair. J Anat. 2003;203:89–99.
Article CAS PubMed PubMed Central Google Scholar
Hill M, Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol. 2003;549:409–18.
Article CAS PubMed PubMed Central Google Scholar
Stavropoulos A, Varras M, Philippou A, Vasilakaki T, Varra VK, Varra FN, et al. Immunohistochemical expression of insulin-like growth factor-1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression. Oncol Lett. 2020;20:395.
PubMed PubMed Central Google Scholar
Karagiannis AK, Philippou A, Tseleni-Balafouta S, Zevolis E, Nakouti T, Tsopanomichalou-Gklotsou M, et al. IGF-IEc expression is associated with advanced differentiated thyroid cancer. Anticancer Res. 2019;39:2811–9.
Article CAS PubMed Google Scholar
Christopoulos PF, Msaouel P, Koutsilieris M. The role of the insulin-like growth factor-1 system in breast cancer. Mol Cancer. 2015;14:43.
留言 (0)